.. _SV2B:

SV2B
^^^^

.. contents::
   :local:

General Information
*******************

:Full gene name: synaptic vesicle glycoprotein 2B
:Entrez Gene ID: 9899
:Location: 15q26.1
:Synonyms: HsT19680
:Type: protein-coding

User SNPs
*********

SNPs given by the user that are near or inside this gene: 

+-----------+---------------+-----------+
|    SNP    | Distance (bp) | Direction |
+===========+===============+===========+
| rs8042680 |     121845    |  upstream |
+-----------+---------------+-----------+

.. _SV2B Gene summary:

NCBI Summary
************

None available.

.. _OMIM ID 185861
                        : http://omim.org/entry/185861
                        

.. _SV2B OMIM Text:

OMIM
****

:OMIM ID: `OMIM ID 185861
                        `_


.. _SV2B Phenotype:

NCBI Phenotypes
***************

* Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum.
* NHGRI GWA Catalog

.. _SV2B GO Term:

Gene Ontology
*************

* synaptic vesicle membrane
* acrosomal vesicle
* transmembrane transporter activity
* integral to membrane
* neurotransmitter transport
* cell junction

.. _SV2B Pathway:

KEGG Pathways
*************

* `ECM-receptor interaction <http://www.genome.jp/dbget-bin/show_pathway?hsa04512+9899>`_

.. _SV2B GeneRIF:

GeneRIFs
********

* Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) [`PMID 20628086`_]
* Affinity Capture-Western [`PMID 15466855`_]
* Affinity Capture-Western [`PMID 15466855`_]
* Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) [`PMID 20379614`_]
* Synaptic vesicle protein 2 binds adenine nucleotides [`PMID 18524768`_]
* Observational study of gene-disease association. (HuGE Navigator) [`PMID 19913121`_]

.. _PMID 20628086: http://www.ncbi.nlm.nih.gov/pubmed/20628086
.. _PMID 15466855: http://www.ncbi.nlm.nih.gov/pubmed/15466855
.. _PMID 20379614: http://www.ncbi.nlm.nih.gov/pubmed/20379614
.. _PMID 18524768: http://www.ncbi.nlm.nih.gov/pubmed/18524768
.. _PMID 19913121: http://www.ncbi.nlm.nih.gov/pubmed/19913121

.. _SV2B Pubmed:

PubMed Articles
***************

*Recent articles:*

* Bailey SD et al. "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." Diabetes Care. 2010 Oct;33(10):2250-3. `PMID 20628086`_
* Rose JE et al. "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." Mol Med. 2010 Jul-Aug;16(7-8):247-53. `PMID 20379614`_
* Talmud PJ et al. "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." Am J Hum Genet. 2009 Nov;85(5):628-42. `PMID 19913121`_
* Lynch JM et al. "No major role of common SV2A variation for predisposition or levetiracetam response in epilepsy." Epilepsy Res. 2009 Jan;83(1):44-51. `PMID 18977120`_
* Gieger C et al. "Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum." PLoS Genet. 2008 Nov;4(11):e1000282. `PMID 19043545`_
* Yao J et al. "Synaptic vesicle protein 2 binds adenine nucleotides." J Biol Chem. 2008 Jul 25;283(30):20628-34. `PMID 18524768`_
* Verma R et al. "Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3." Biol Psychiatry. 2008 Jun 15;63(12):1185-9. `PMID 18367154`_
* Girard A et al. "A germline-specific class of small RNAs binds mammalian Piwi proteins." Nature. 2006 Jul 13;442(7099):199-202. `PMID 16751776`_
* Lazzell DR et al. "SV2B regulates synaptotagmin 1 by direct interaction." J Biol Chem. 2004 Dec 10;279(50):52124-31. `PMID 15466855`_
* Gerhard DS et al. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 2004 Oct;14(10B):2121-7. `PMID 15489334`_

.. _PMID 18524768: http://www.ncbi.nlm.nih.gov/pubmed/18524768
.. _PMID 18977120: http://www.ncbi.nlm.nih.gov/pubmed/18977120
.. _PMID 19043545: http://www.ncbi.nlm.nih.gov/pubmed/19043545
.. _PMID 18367154: http://www.ncbi.nlm.nih.gov/pubmed/18367154
.. _PMID 20628086: http://www.ncbi.nlm.nih.gov/pubmed/20628086
.. _PMID 20379614: http://www.ncbi.nlm.nih.gov/pubmed/20379614
.. _PMID 16751776: http://www.ncbi.nlm.nih.gov/pubmed/16751776
.. _PMID 15466855: http://www.ncbi.nlm.nih.gov/pubmed/15466855
.. _PMID 19913121: http://www.ncbi.nlm.nih.gov/pubmed/19913121
.. _PMID 15489334: http://www.ncbi.nlm.nih.gov/pubmed/15489334

*Top Pubmed articles linked to gene SV2B matching any search term:* 

* Bailey SD et al. "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." Diabetes Care. 2010 Oct;33(10):2250-3. `PMID 20628086`_
* Iezzi M et al. "SV2A and SV2C are not vesicular Ca2+ transporters but control glucose-evoked granule recruitment." J Cell Sci. 2005 Dec 1;118(Pt 23):5647-60. `PMID 16306227`_
* Bajjalieh SM et al. "Brain contains two forms of synaptic vesicle protein 2." Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2150-4. `PMID 7681585`_

.. _PMID 20628086: http://www.ncbi.nlm.nih.gov/pubmed/20628086
.. _PMID 7681585: http://www.ncbi.nlm.nih.gov/pubmed/7681585
.. _PMID 16306227: http://www.ncbi.nlm.nih.gov/pubmed/16306227