.. _SYNRG:

SYNRG
^^^^^

.. contents::
   :local:

General Information
*******************

:Full gene name: synergin, gamma
:Entrez Gene ID: 11276
:Location: 17q12
:Synonyms: SYNG, AP1GBP1
:Type: protein-coding

User SNPs
*********

SNPs given by the user that are near or inside this gene: 

+----------+---------------+-----------+
|   SNP    | Distance (bp) | Direction |
+==========+===============+===========+
| rs757210 |     127029    |  upstream |
+----------+---------------+-----------+

.. _SYNRG Gene summary:

NCBI Summary
************

This gene encodes a protein that interacts with the gamma subunit of AP1 clathrin-adaptor complex. The AP1 complex is located at the trans-Golgi network and associates specific proteins with clathrin-coated vesicles. This encoded protein may act to connect the AP1 complex to other proteins. Alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

.. _SYNRG OMIM Text:

OMIM
****

No OMIM data available for this gene.

.. _SYNRG Phenotype:

NCBI Phenotypes
***************

* NHGRI GWA Catalog
* Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.

.. _SYNRG GO Term:

Gene Ontology
*************

* calcium ion binding
* Golgi apparatus
* cytoplasm
* endocytosis
* AP-1 adaptor complex
* intracellular protein transport

.. _SYNRG Pathway:

KEGG Pathways
*************

No pathways found linked to this gene.

.. _SYNRG GeneRIF:

GeneRIFs
********

* Two-hybrid [`PMID 10814529`_]
* Two-hybrid [`PMID 10814529`_]
* AP-3 and AP-1 function in partially redundant pathways to transfer tyrosinase from distinct endosomal subdomains to melanosomes [`PMID 16162817`_]
* Reconstituted Complex; Two-hybrid [`PMID 10777571`_]
* Data show that by recruiting aftiphilin/gamma-synergin in addition to clathrin, AP-1 coordinates formation of Weibel-Palade bodies with their acquisition of a regulated secretory phenotype. [`PMID 18815278`_]
* the aftiphilin/p200/gamma-synergin complex facilitates AP-1 function [`PMID 15758025`_]
* Reconstituted Complex; Two-hybrid [`PMID 12042876`_]

.. _PMID 10814529: http://www.ncbi.nlm.nih.gov/pubmed/10814529
.. _PMID 16162817: http://www.ncbi.nlm.nih.gov/pubmed/16162817
.. _PMID 10777571: http://www.ncbi.nlm.nih.gov/pubmed/10777571
.. _PMID 18815278: http://www.ncbi.nlm.nih.gov/pubmed/18815278
.. _PMID 15758025: http://www.ncbi.nlm.nih.gov/pubmed/15758025
.. _PMID 12042876: http://www.ncbi.nlm.nih.gov/pubmed/12042876

.. _SYNRG Pubmed:

PubMed Articles
***************

*Recent articles:*

* Turner ST et al. "Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker." Hypertension. 2012 Jun;59(6):1204-11. `PMID 22566498`_
* Lui-Roberts WW et al. "Aftiphilin and gamma-synergin are required for secretagogue sensitivity of Weibel-Palade bodies in endothelial cells." Mol Biol Cell. 2008 Dec;19(12):5072-81. `PMID 18815278`_
* Kimura K et al. "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes." Genome Res. 2006 Jan;16(1):55-65. `PMID 16344560`_
* Theos AC et al. "Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes." Mol Biol Cell. 2005 Nov;16(11):5356-72. `PMID 16162817`_
* Hirst J et al. "The aftiphilin/p200/gamma-synergin complex." Mol Biol Cell. 2005 May;16(5):2554-65. `PMID 15758025`_
* Gerhard DS et al. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 2004 Oct;14(10B):2121-7. `PMID 15489334`_
* Beausoleil SA et al. "Large-scale characterization of HeLa cell nuclear phosphoproteins." Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12130-5. `PMID 15302935`_
* Ota T et al. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat Genet. 2004 Jan;36(1):40-5. `PMID 14702039`_
* Lui WW et al. "Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin." Mol Biol Cell. 2003 Jun;14(6):2385-98. `PMID 12808037`_
* Mills IG et al. "EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking." J Cell Biol. 2003 Jan 20;160(2):213-22. `PMID 12538641`_

.. _PMID 16162817: http://www.ncbi.nlm.nih.gov/pubmed/16162817
.. _PMID 22566498: http://www.ncbi.nlm.nih.gov/pubmed/22566498
.. _PMID 14702039: http://www.ncbi.nlm.nih.gov/pubmed/14702039
.. _PMID 18815278: http://www.ncbi.nlm.nih.gov/pubmed/18815278
.. _PMID 15302935: http://www.ncbi.nlm.nih.gov/pubmed/15302935
.. _PMID 12808037: http://www.ncbi.nlm.nih.gov/pubmed/12808037
.. _PMID 15758025: http://www.ncbi.nlm.nih.gov/pubmed/15758025
.. _PMID 16344560: http://www.ncbi.nlm.nih.gov/pubmed/16344560
.. _PMID 12538641: http://www.ncbi.nlm.nih.gov/pubmed/12538641
.. _PMID 15489334: http://www.ncbi.nlm.nih.gov/pubmed/15489334

*Top Pubmed articles linked to gene SYNRG matching any search term:* 

* Hendrix NW et al. "Prenatally diagnosed 17q12 microdeletion syndrome with a novel association with congenital diaphragmatic hernia." Fetal Diagn Ther. 2012;31(2):129-33. `PMID 22178801`_

.. _PMID 22178801: http://www.ncbi.nlm.nih.gov/pubmed/22178801