.. _TBC1D3:

TBC1D3
^^^^^^

.. contents::
   :local:

General Information
*******************

:Full gene name: TBC1 domain family, member 3
:Entrez Gene ID: 729873
:Location: 17q12
:Synonyms: PRC17, TBC1D3A, TBC1D3F
:Type: protein-coding

User SNPs
*********

SNPs given by the user that are near or inside this gene: 

+----------+---------------+------------+
|   SNP    | Distance (bp) | Direction  |
+==========+===============+============+
| rs757210 |     187445    | downstream |
+----------+---------------+------------+

.. _TBC1D3 Gene summary:

NCBI Summary
************

None available.

.. _OMIM ID 607741
                        : http://omim.org/entry/607741
                        

.. _TBC1D3 OMIM Text:

OMIM
****

:OMIM ID: `OMIM ID 607741
                        `_


.. _TBC1D3 Phenotype:

NCBI Phenotypes
***************

No phenotypes found linked to this gene.

.. _TBC1D3 GO Term:

Gene Ontology
*************

* Rab GTPase activator activity
* intracellular

.. _TBC1D3 Pathway:

KEGG Pathways
*************

No pathways found linked to this gene.

.. _TBC1D3 GeneRIF:

GeneRIFs
********

* We describe eight highly related TBC1D3 paralogues located on Chromosome 17q12 that display specific transcription patterns in human tissues, and that pattern is altered in several primary prostate tumors in comparison to healthy prostate tissues. [`PMID 16863688`_]
* TBC1D3 plays an unanticipated and potentially unique role in the fine-tuning of \ ``insulin``\ /IGF-1 signaling [`PMID 22348058`_]
* Altered growth factor receptor trafficking and GTP-Ras turnover may be sites where recently evolved genes such as TBC1D3 selectively modulate signaling in hominoids and humans [`PMID 18319245`_]

.. _PMID 16863688: http://www.ncbi.nlm.nih.gov/pubmed/16863688
.. _PMID 22348058: http://www.ncbi.nlm.nih.gov/pubmed/22348058
.. _PMID 18319245: http://www.ncbi.nlm.nih.gov/pubmed/18319245

.. _TBC1D3 Pubmed:

PubMed Articles
***************

*Recent articles:*

* Wainszelbaum MJ et al. "TBC1D3, a hominoid-specific gene, delays IRS-1 degradation and promotes insulin signaling by modulating p70 S6 kinase activity." PLoS One. 2012;7(2):e31225. `PMID 22348058`_
* Alkan C et al. "Personalized copy number and segmental duplication maps using next-generation sequencing." Nat Genet. 2009 Oct;41(10):1061-7. `PMID 19718026`_
* Wainszelbaum MJ et al. "The hominoid-specific oncogene TBC1D3 activates Ras and modulates epidermal growth factor receptor signaling and trafficking." J Biol Chem. 2008 May 9;283(19):13233-42. `PMID 18319245`_
* Hodzic D et al. "TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12." Genomics. 2006 Dec;88(6):731-6. `PMID 16863688`_
* Zody MC et al. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature. 2006 Apr 20;440(7087):1045-9. `PMID 16625196`_
* Paulding CA et al. "The Tre2 (USP6) oncogene is a hominoid-specific gene." Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2507-11. `PMID 12604796`_
* Masuda-Robens JM et al. "The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling." Mol Cell Biol. 2003 Mar;23(6):2151-61. `PMID 12612085`_
* Pei L et al. "PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer." Cancer Res. 2002 Oct 1;62(19):5420-4. `PMID 12359748`_
* Wiemann S et al. "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 2001 Mar;11(3):422-35. `PMID 11230166`_
* Onno M et al. "Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes." DNA Cell Biol. 1993 Mar;12(2):107-18. `PMID 8471161`_

.. _PMID 8471161: http://www.ncbi.nlm.nih.gov/pubmed/8471161
.. _PMID 19718026: http://www.ncbi.nlm.nih.gov/pubmed/19718026
.. _PMID 22348058: http://www.ncbi.nlm.nih.gov/pubmed/22348058
.. _PMID 12612085: http://www.ncbi.nlm.nih.gov/pubmed/12612085
.. _PMID 16863688: http://www.ncbi.nlm.nih.gov/pubmed/16863688
.. _PMID 12359748: http://www.ncbi.nlm.nih.gov/pubmed/12359748
.. _PMID 11230166: http://www.ncbi.nlm.nih.gov/pubmed/11230166
.. _PMID 16625196: http://www.ncbi.nlm.nih.gov/pubmed/16625196
.. _PMID 12604796: http://www.ncbi.nlm.nih.gov/pubmed/12604796
.. _PMID 18319245: http://www.ncbi.nlm.nih.gov/pubmed/18319245

*Top Pubmed articles linked to gene TBC1D3 matching any search term:* 

* Wainszelbaum MJ et al. "TBC1D3, a hominoid-specific gene, delays IRS-1 degradation and promotes insulin signaling by modulating p70 S6 kinase activity." PLoS One. 2012;7(2):e31225. `PMID 22348058`_

.. _PMID 22348058: http://www.ncbi.nlm.nih.gov/pubmed/22348058