.. _THADA: THADA ^^^^^ .. contents:: :local: General Information ******************* :Full gene name: thyroid adenoma associated :Entrez Gene ID: 63892 :Location: 2p21 :Synonyms: GITA :Type: protein-coding User SNPs ********* SNPs given by the user that are near or inside this gene: +-----------+---------------+-----------+ | SNP | Distance (bp) | Direction | +===========+===============+===========+ | rs7578597 | 0 | within | +-----------+---------------+-----------+ .. _THADA Gene summary: NCBI Summary ************ None available. .. _OMIM ID 611800 : http://omim.org/entry/611800 .. _THADA OMIM Text: OMIM **** :OMIM ID: `OMIM ID 611800 `_ .. _THADA Phenotype: NCBI Phenotypes *************** * New gene functions in megakaryopoiesis and platelet formation. * Common variants in the trichohyalin gene are associated with straight hair in Europeans. * Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 \ ``diabetes``\ . * Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. * Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate. * Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. * Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. * NHGRI GWA Catalog * Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. .. _THADA GO Term: Gene Ontology ************* No GO terms found linked to this gene. .. _THADA Pathway: KEGG Pathways ************* No pathways found linked to this gene. .. _THADA GeneRIF: GeneRIFs ******** * Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) [`PMID 20889853`_] * Observational study of gene-disease association. (HuGE Navigator) [`PMID 20816152`_] * Meta-analysis of gene-disease association. (HuGE Navigator) [`PMID 20564319`_] * Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator) [`PMID 20075150`_] * intronic sequence of PPAR(gamma) is fused to exon 28 of THADA in thyroid tumors of follicular origin including carcinomas as well as adenomas [`PMID 17123335`_] * Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) [`PMID 18372903`_] * Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) [`PMID 20379614`_] * Affinity Capture-MS [`PMID 21987572`_] * Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) [`PMID 20571754`_] * Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) [`PMID 20878950`_] * Meta-analysis and HuGE review of gene-disease association. (HuGE Navigator) [`PMID 19602701`_] * Observational study and meta-analysis of gene-disease association. (HuGE Navigator) [`PMID 20490451`_] * Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) [`PMID 20879858`_] * identification of the target gene of 2p21 aberrations in thyroid adenomas tentatively referred to as thyroid adenoma-associated gene (THADA); gene spans roughly 365 kbp; based on preliminary results, it encodes a death receptor-interacting protein [THADA] [`PMID 12955091`_] * At least two of the PCOS susceptibility loci identified in the Chinese PCOS GWAS (DENND1A and THADA) are also associated with PCOS in European derived populations. [`PMID 22180642`_] .. _PMID 20889853: http://www.ncbi.nlm.nih.gov/pubmed/20889853 .. _PMID 20816152: http://www.ncbi.nlm.nih.gov/pubmed/20816152 .. _PMID 20564319: http://www.ncbi.nlm.nih.gov/pubmed/20564319 .. _PMID 20075150: http://www.ncbi.nlm.nih.gov/pubmed/20075150 .. _PMID 17123335: http://www.ncbi.nlm.nih.gov/pubmed/17123335 .. _PMID 18372903: http://www.ncbi.nlm.nih.gov/pubmed/18372903 .. _PMID 20379614: http://www.ncbi.nlm.nih.gov/pubmed/20379614 .. _PMID 21987572: http://www.ncbi.nlm.nih.gov/pubmed/21987572 .. _PMID 20571754: http://www.ncbi.nlm.nih.gov/pubmed/20571754 .. _PMID 20878950: http://www.ncbi.nlm.nih.gov/pubmed/20878950 .. _PMID 19602701: http://www.ncbi.nlm.nih.gov/pubmed/19602701 .. _PMID 20490451: http://www.ncbi.nlm.nih.gov/pubmed/20490451 .. _PMID 20879858: http://www.ncbi.nlm.nih.gov/pubmed/20879858 .. _PMID 12955091: http://www.ncbi.nlm.nih.gov/pubmed/12955091 .. _PMID 22180642: http://www.ncbi.nlm.nih.gov/pubmed/22180642 .. _THADA Pubmed: PubMed Articles *************** *Recent articles:* * Goodarzi MO et al. "Replication of association of DENND1A and THADA variants with polycystic ovary syndrome in European cohorts." J Med Genet. 2012 Feb;49(2):90-5. `PMID 22180642`_ * Lee KA et al. "Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels." J Biol Chem. 2011 Dec 2;286(48):41530-8. `PMID 21987572`_ * Patsopoulos NA et al. "Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci." Ann Neurol. 2011 Dec;70(6):897-912. `PMID 22190364`_ * Gieger C et al. "New gene functions in megakaryopoiesis and platelet formation." Nature. 2011 Nov 30;480(7376):201-8. `PMID 22139419`_ * Kim W et al. "Systematic and quantitative assessment of the ubiquitin-modified proteome." Mol Cell. 2011 Oct 21;44(2):325-40. `PMID 21906983`_ * Wagner SA et al. "A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles." Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. `PMID 21890473`_ * Danielsen JM et al. "Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level." Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. `PMID 21139048`_ * de Miguel-Yanes JM et al. "Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms." Diabetes Care. 2011 Jan;34(1):121-5. `PMID 20889853`_ * Chen ZJ et al. "Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3." Nat Genet. 2011 Jan;43(1):55-9. `PMID 21151128`_ * Franke A et al. "Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci." Nat Genet. 2010 Dec;42(12):1118-25. `PMID 21102463`_ .. _PMID 21890473: http://www.ncbi.nlm.nih.gov/pubmed/21890473 .. _PMID 22139419: http://www.ncbi.nlm.nih.gov/pubmed/22139419 .. _PMID 20889853: http://www.ncbi.nlm.nih.gov/pubmed/20889853 .. _PMID 21139048: http://www.ncbi.nlm.nih.gov/pubmed/21139048 .. _PMID 21987572: http://www.ncbi.nlm.nih.gov/pubmed/21987572 .. _PMID 21102463: http://www.ncbi.nlm.nih.gov/pubmed/21102463 .. _PMID 22190364: http://www.ncbi.nlm.nih.gov/pubmed/22190364 .. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983 .. _PMID 21151128: http://www.ncbi.nlm.nih.gov/pubmed/21151128 .. _PMID 22180642: http://www.ncbi.nlm.nih.gov/pubmed/22180642 *Top Pubmed articles linked to gene THADA matching any search term:* * Eriksen MB et al. "Association of polycystic ovary syndrome susceptibility single nucleotide polymorphism rs2479106 and PCOS in Caucasian patients with PCOS or hirsutism as referral diagnosis." Eur J Obstet Gynecol Reprod Biol. 2012 Jul;163(1):39-42. `PMID 22504079`_ * Hotta K et al. "Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography." J Hum Genet. 2012 May;57(5):305-10. `PMID 22377712`_ * Saxena R et al. "Polycystic ovary syndrome is not associated with genetic variants that mark risk of type 2 diabetes." Acta Diabetol. 2012 Mar 3;. `PMID 22389004`_ * Gupta V et al. "Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs." Diabetologia. 2012 Feb;55(2):349-57. `PMID 22052079`_ * Goodarzi MO et al. "Replication of association of DENND1A and THADA variants with polycystic ovary syndrome in European cohorts." J Med Genet. 2012 Feb;49(2):90-5. `PMID 22180642`_ * Cheng I et al. "Type 2 diabetes risk variants and colorectal cancer risk: the Multiethnic Cohort and PAGE studies." Gut. 2011 Dec;60(12):1703-11. `PMID 21602532`_ * Vangipurapu J et al. "Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men." Diabetologia. 2011 Mar;54(3):563-71. `PMID 21153532`_ * de Miguel-Yanes JM et al. "Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms." Diabetes Care. 2011 Jan;34(1):121-5. `PMID 20889853`_ * Klimentidis YC et al. "Ancestry-informative markers on chromosomes 2, 8 and 15 are associated with insulin-related traits in a racially diverse sample of children." Hum Genomics. 2011 Jan;5(2):79-89. `PMID 21296741`_ * Stuebe AM et al. "Obesity and diabetes genetic variants associated with gestational weight gain." Am J Obstet Gynecol. 2010 Sep;203(3):283.e1-17. `PMID 20816152`_ * Morgan AR et al. "Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study." BMC Med Genet. 2010 Aug 16;11:125. `PMID 20712903`_ * Pierce BL et al. "Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk." Hum Hered. 2010;69(3):193-201. `PMID 20203524`_ * Talmud PJ et al. "Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study." BMJ. 2010 Jan 14;340:b4838. `PMID 20075150`_ * Schleinitz D et al. "Lack of significant effects of the type 2 diabetes susceptibility loci JAZF1, CDC123/CAMK1D, NOTCH2, ADAMTS9, THADA, and TSPAN8/LGR5 on diabetes and quantitative metabolic traits." Horm Metab Res. 2010 Jan;42(1):14-22. `PMID 19670153`_ * Parikh H et al. "Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus." BMC Med Genomics. 2009 Dec 31;2:72. `PMID 20043853`_ * Schulze MB et al. "Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam Study." Diabetes Care. 2009 Nov;32(11):2116-9. `PMID 19720844`_ * Hu C et al. "PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population." PLoS One. 2009 Oct 28;4(10):e7643. `PMID 19862325`_ * Stancáková A et al. "Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men." Diabetes. 2009 Sep;58(9):2129-36. `PMID 19502414`_ * Lin X et al. "Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study." Diabetologia. 2009 Apr;52(4):600-8. `PMID 19139842`_ .. _PMID 19502414: http://www.ncbi.nlm.nih.gov/pubmed/19502414 .. _PMID 20889853: http://www.ncbi.nlm.nih.gov/pubmed/20889853 .. _PMID 20712903: http://www.ncbi.nlm.nih.gov/pubmed/20712903 .. _PMID 22052079: http://www.ncbi.nlm.nih.gov/pubmed/22052079 .. _PMID 22389004: http://www.ncbi.nlm.nih.gov/pubmed/22389004 .. _PMID 20816152: http://www.ncbi.nlm.nih.gov/pubmed/20816152 .. _PMID 19862325: http://www.ncbi.nlm.nih.gov/pubmed/19862325 .. _PMID 19720844: http://www.ncbi.nlm.nih.gov/pubmed/19720844 .. _PMID 20043853: http://www.ncbi.nlm.nih.gov/pubmed/20043853 .. _PMID 20075150: http://www.ncbi.nlm.nih.gov/pubmed/20075150 .. _PMID 20203524: http://www.ncbi.nlm.nih.gov/pubmed/20203524 .. _PMID 19139842: http://www.ncbi.nlm.nih.gov/pubmed/19139842 .. _PMID 21602532: http://www.ncbi.nlm.nih.gov/pubmed/21602532 .. _PMID 19670153: http://www.ncbi.nlm.nih.gov/pubmed/19670153 .. _PMID 21153532: http://www.ncbi.nlm.nih.gov/pubmed/21153532 .. _PMID 22504079: http://www.ncbi.nlm.nih.gov/pubmed/22504079 .. _PMID 21296741: http://www.ncbi.nlm.nih.gov/pubmed/21296741 .. _PMID 22180642: http://www.ncbi.nlm.nih.gov/pubmed/22180642 .. _PMID 22377712: http://www.ncbi.nlm.nih.gov/pubmed/22377712