.. _TLE4:

TLE4
^^^^

.. contents::
   :local:

General Information
*******************

:Full gene name: transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
:Entrez Gene ID: 7091
:Location: 9q21.31
:Synonyms: E(spI), GRG4, ESG4, BCE1, BCE-1, ESG
:Type: protein-coding

User SNPs
*********

SNPs given by the user that are near or inside this gene: 

+------------+---------------+-----------+
|    SNP     | Distance (bp) | Direction |
+============+===============+===========+
| rs13292136 |     234750    |  upstream |
+------------+---------------+-----------+

.. _TLE4 Gene summary:

NCBI Summary
************

None available.

.. _OMIM ID 605132
                        : http://omim.org/entry/605132
                        

.. _TLE4 OMIM Text:

OMIM
****

:OMIM ID: `OMIM ID 605132
                        `_


.. _TLE4 Phenotype:

NCBI Phenotypes
***************

* NHGRI GWA Catalog
* Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children.
* Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.

.. _TLE4 GO Term:

Gene Ontology
*************

* negative regulation of transcription from RNA polymerase II promoter
* chromatin binding
* Wnt receptor signaling pathway
* nucleoplasm
* repressing transcription factor binding
* molecular_function
* nucleus
* transcription, DNA-dependent
* transcription corepressor activity
* biological_process
* Notch signaling pathway

.. _TLE4 Pathway:

KEGG Pathways
*************

No pathways found linked to this gene.

.. _TLE4 GeneRIF:

GeneRIFs
********

* germ cell-specific RBMY and hnRNP G-T proteins were more efficient in stimulating TLE4-T incorporation than somatically expressed hnRNP G protein. [`PMID 19893608`_]
* Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) [`PMID 20889853`_]
* Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) [`PMID 19714205`_]
* Knockdown of TLE1 or TLE4 levels increased the rate of cell division of the AML1-ETO-expressing Kasumi-1 cell line, whereas forced expression of either TLE1 or TLE4 caused apoptosis and cell death. [`PMID 18258796`_]
* Affinity Capture-MS [`PMID 21890473`_]
* Observational study of gene-disease association. (HuGE Navigator) [`PMID 20816195`_]
* Grg4 recruits the arginine methyltransferase PRMT5 to chromatin resulting in symmetric H4R3 dimethylation. [`PMID 22169276`_]
* Affinity Capture-MS; Affinity Capture-Western [`PMID 22169276`_]
* Affinity Capture-MS; Affinity Capture-Western [`PMID 22169276`_]
* Affinity Capture-MS; Affinity Capture-Western [`PMID 22169276`_]
* Affinity Capture-Western [`PMID 11266540`_]
* Affinity Capture-Western; Reconstituted Complex [`PMID 19332113`_]
* Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors [`PMID 17060451`_]
* Affinity Capture-Western; Reconstituted Complex; Two-hybrid [`PMID 12153506`_]

.. _PMID 19893608: http://www.ncbi.nlm.nih.gov/pubmed/19893608
.. _PMID 20889853: http://www.ncbi.nlm.nih.gov/pubmed/20889853
.. _PMID 19714205: http://www.ncbi.nlm.nih.gov/pubmed/19714205
.. _PMID 18258796: http://www.ncbi.nlm.nih.gov/pubmed/18258796
.. _PMID 21890473: http://www.ncbi.nlm.nih.gov/pubmed/21890473
.. _PMID 20816195: http://www.ncbi.nlm.nih.gov/pubmed/20816195
.. _PMID 22169276: http://www.ncbi.nlm.nih.gov/pubmed/22169276
.. _PMID 11266540: http://www.ncbi.nlm.nih.gov/pubmed/11266540
.. _PMID 19332113: http://www.ncbi.nlm.nih.gov/pubmed/19332113
.. _PMID 17060451: http://www.ncbi.nlm.nih.gov/pubmed/17060451
.. _PMID 12153506: http://www.ncbi.nlm.nih.gov/pubmed/12153506

.. _TLE4 Pubmed:

PubMed Articles
***************

*Recent articles:*

* Patel SR et al. "Epigenetic mechanisms of Groucho/Grg/TLE mediated transcriptional repression." Mol Cell. 2012 Jan 27;45(2):185-95. `PMID 22169276`_
* Al-Balool HH et al. "Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant." Genome Res. 2011 Nov;21(11):1788-99. `PMID 21948523`_
* Wagner SA et al. "A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles." Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. `PMID 21890473`_
* Danielsen JM et al. "Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level." Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. `PMID 21139048`_
* Jiang Y et al. "Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder." Genet Epidemiol. 2011 Feb;35(2):125-32. `PMID 21254220`_
* de Miguel-Yanes JM et al. "Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms." Diabetes Care. 2011 Jan;34(1):121-5. `PMID 20889853`_
* Melén E et al. "Analyses of shared genetic factors between asthma and obesity in children." J Allergy Clin Immunol. 2010 Sep;126(3):631-7.e1-8. `PMID 20816195`_
* Liu Y et al. "The germ cell nuclear proteins hnRNP G-T and RBMY activate a testis-specific exon." PLoS Genet. 2009 Nov;5(11):e1000707. `PMID 19893608`_
* Hancock DB et al. "Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children." PLoS Genet. 2009 Aug;5(8):e1000623. `PMID 19714205`_
* Sharma M et al. "The homeodomain protein Cux1 interacts with Grg4 to repress p27 kip1 expression during kidney development." Gene. 2009 Jun 15;439(1-2):87-94. `PMID 19332113`_

.. _PMID 21890473: http://www.ncbi.nlm.nih.gov/pubmed/21890473
.. _PMID 21139048: http://www.ncbi.nlm.nih.gov/pubmed/21139048
.. _PMID 21948523: http://www.ncbi.nlm.nih.gov/pubmed/21948523
.. _PMID 20889853: http://www.ncbi.nlm.nih.gov/pubmed/20889853
.. _PMID 21254220: http://www.ncbi.nlm.nih.gov/pubmed/21254220
.. _PMID 20816195: http://www.ncbi.nlm.nih.gov/pubmed/20816195
.. _PMID 22169276: http://www.ncbi.nlm.nih.gov/pubmed/22169276
.. _PMID 19714205: http://www.ncbi.nlm.nih.gov/pubmed/19714205
.. _PMID 19893608: http://www.ncbi.nlm.nih.gov/pubmed/19893608
.. _PMID 19332113: http://www.ncbi.nlm.nih.gov/pubmed/19332113

*Top Pubmed articles linked to gene TLE4 matching any search term:* 

* de Miguel-Yanes JM et al. "Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms." Diabetes Care. 2011 Jan;34(1):121-5. `PMID 20889853`_
* Hoffman BG et al. "Expression of Groucho/TLE proteins during pancreas development." BMC Dev Biol. 2008 Sep 8;8:81. `PMID 18778483`_
* Doyle MJ et al. "Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet." Development. 2007 Feb;134(3):515-23. `PMID 17202186`_

.. _PMID 20889853: http://www.ncbi.nlm.nih.gov/pubmed/20889853
.. _PMID 18778483: http://www.ncbi.nlm.nih.gov/pubmed/18778483
.. _PMID 17202186: http://www.ncbi.nlm.nih.gov/pubmed/17202186