.. _TREX2: TREX2 ^^^^^ .. contents:: :local: General Information ******************* :Full gene name: three prime repair exonuclease 2 :Entrez Gene ID: 11219 :Location: Xq28 :Synonyms: :Type: protein-coding User SNPs ********* SNPs given by the user that are near or inside this gene: +-----------+---------------+-----------+ | SNP | Distance (bp) | Direction | +===========+===============+===========+ | rs3020789 | 181042 | upstream | +-----------+---------------+-----------+ .. _TREX2 Gene summary: NCBI Summary ************ This gene encodes a protein with 3' exonuclease activity. Enzymes with this activity are involved in DNA replication, repair, and recombination. Similarity to an E. coli protein suggests that this enzyme may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity. [provided by RefSeq, Jul 2008] .. _OMIM ID 300370 : http://omim.org/entry/300370 .. _TREX2 OMIM Text: OMIM **** :OMIM ID: `OMIM ID 300370 `_ .. _TREX2 Phenotype: NCBI Phenotypes *************** No phenotypes found linked to this gene. .. _TREX2 GO Term: Gene Ontology ************* * exodeoxyribonuclease III activity * nucleic acid binding * DNA repair * nucleus * 3'-5'-exodeoxyribonuclease activity .. _TREX2 Pathway: KEGG Pathways ************* No pathways found linked to this gene. .. _TREX2 GeneRIF: GeneRIFs ******** * Trex2 does not enable DSB repair and prompt a new model that posits Trex2 suppresses the formation of broken chromosomes. [`PMID 21546543`_] * Two-hybrid [`PMID 16189514`_] * analysis of human TREX2 3' -> 5'-exonuclease structure and description of the mechanism for efficient nonprocessive DNA catalysis [`PMID 15661738`_] * Co-fractionation [`PMID 11279105`_] * analysis of cooperative DNA binding and communication across the dimer interface in the TREX2 3' --> 5'-exonuclease [`PMID 18534978`_] * Observational study of gene-disease association. (HuGE Navigator) [`PMID 18092167`_] * a model for DNA binding and 3' hydrolysis for the TREX2 dimer. [`PMID 19321497`_] * Polymorphisms exist in prostatic cancer patients. [`PMID 15581481`_] * Trex2 deletion caused high levels of Robertsonian translocations (RbTs) showing Trex2 is important for chromosomal maintenance. [`PMID 19094998`_] * Results suggest that TREX2 plays an important function during DNA metabolism and cellular proliferation. [`PMID 17426129`_] * UCH37 interacts with UIP1. [`PMID 11163772`_] .. _PMID 21546543: http://www.ncbi.nlm.nih.gov/pubmed/21546543 .. _PMID 16189514: http://www.ncbi.nlm.nih.gov/pubmed/16189514 .. _PMID 15661738: http://www.ncbi.nlm.nih.gov/pubmed/15661738 .. _PMID 11279105: http://www.ncbi.nlm.nih.gov/pubmed/11279105 .. _PMID 18534978: http://www.ncbi.nlm.nih.gov/pubmed/18534978 .. _PMID 18092167: http://www.ncbi.nlm.nih.gov/pubmed/18092167 .. _PMID 19321497: http://www.ncbi.nlm.nih.gov/pubmed/19321497 .. _PMID 15581481: http://www.ncbi.nlm.nih.gov/pubmed/15581481 .. _PMID 19094998: http://www.ncbi.nlm.nih.gov/pubmed/19094998 .. _PMID 17426129: http://www.ncbi.nlm.nih.gov/pubmed/17426129 .. _PMID 11163772: http://www.ncbi.nlm.nih.gov/pubmed/11163772 .. _TREX2 Pubmed: PubMed Articles *************** *Recent articles:* * Dumitrache LC et al. "Trex2 enables spontaneous sister chromatid exchanges without facilitating DNA double-strand break repair." Genetics. 2011 Aug;188(4):787-97. `PMID 21546543`_ * de Silva U et al. "DNA binding induces active site conformational change in the human TREX2 3'-exonuclease." Nucleic Acids Res. 2009 Apr;37(7):2411-7. `PMID 19321497`_ * Dumitrache LC et al. "TREX2 exonuclease defective cells exhibit double-strand breaks and chromosomal fragments but not Robertsonian translocations." Mutat Res. 2009 Mar 9;662(1-2):84-7. `PMID 19094998`_ * Perrino FW et al. "Cooperative DNA binding and communication across the dimer interface in the TREX2 3' --> 5'-exonuclease." J Biol Chem. 2008 Aug 1;283(31):21441-52. `PMID 18534978`_ * Hur JW et al. "TREX1 polymorphisms associated with autoantibodies in patients with systemic lupus erythematosus." Rheumatol Int. 2008 Jun;28(8):783-9. `PMID 18092167`_ * Chen MJ et al. "Biochemical and cellular characteristics of the 3' -> 5' exonuclease TREX2." Nucleic Acids Res. 2007;35(8):2682-94. `PMID 17426129`_ * Hahn Y et al. "Human-specific nonsense mutations identified by genome sequence comparisons." Hum Genet. 2006 Mar;119(1-2):169-78. `PMID 16395595`_ * Mehrle A et al. "The LIFEdb database in 2006." Nucleic Acids Res. 2006 Jan 1;34(Database issue):D415-8. `PMID 16381901`_ * Rual JF et al. "Towards a proteome-scale map of the human protein-protein interaction network." Nature. 2005 Oct 20;437(7062):1173-8. `PMID 16189514`_ * Perrino FW et al. "The human TREX2 3' -> 5'-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysis." J Biol Chem. 2005 Apr 15;280(15):15212-8. `PMID 15661738`_ .. _PMID 21546543: http://www.ncbi.nlm.nih.gov/pubmed/21546543 .. _PMID 16189514: http://www.ncbi.nlm.nih.gov/pubmed/16189514 .. _PMID 15661738: http://www.ncbi.nlm.nih.gov/pubmed/15661738 .. _PMID 16395595: http://www.ncbi.nlm.nih.gov/pubmed/16395595 .. _PMID 18534978: http://www.ncbi.nlm.nih.gov/pubmed/18534978 .. _PMID 19321497: http://www.ncbi.nlm.nih.gov/pubmed/19321497 .. _PMID 18092167: http://www.ncbi.nlm.nih.gov/pubmed/18092167 .. _PMID 19094998: http://www.ncbi.nlm.nih.gov/pubmed/19094998 .. _PMID 17426129: http://www.ncbi.nlm.nih.gov/pubmed/17426129 .. _PMID 16381901: http://www.ncbi.nlm.nih.gov/pubmed/16381901 *Top Pubmed articles linked to gene TREX2 matching any search term:* * Chu Q et al. "Differential gene expression pattern of diabetic rat retinas after intravitreal injection of erythropoietin." Clin Experiment Ophthalmol. 2011 Mar;39(2):142-51. `PMID 20973890`_ * Colbert LH et al. "Exercise effects on tumorigenesis in a p53-deficient mouse model of breast cancer." Med Sci Sports Exerc. 2009 Aug;41(8):1597-605. `PMID 19568200`_ .. _PMID 20973890: http://www.ncbi.nlm.nih.gov/pubmed/20973890 .. _PMID 19568200: http://www.ncbi.nlm.nih.gov/pubmed/19568200