.. _TRPM5:

TRPM5
^^^^^

.. contents::
   :local:

General Information
*******************

:Full gene name: transient receptor potential cation channel, subfamily M, member 5
:Entrez Gene ID: 29850
:Location: 11p15.5
:Synonyms: LTRPC5, MTR1
:Type: protein-coding

User SNPs
*********

SNPs given by the user that are near or inside this gene: 

+----------+---------------+-----------+
|   SNP    | Distance (bp) | Direction |
+==========+===============+===========+
| rs231362 |     247196    |  upstream |
+----------+---------------+-----------+

.. _TRPM5 Gene summary:

NCBI Summary
************

This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele. [provided by RefSeq, Oct 2010]

.. _OMIM ID 604600
                        : http://omim.org/entry/604600
                        

.. _TRPM5 OMIM Text:

OMIM
****

:OMIM ID: `OMIM ID 604600
                        `_


.. _TRPM5 Phenotype:

NCBI Phenotypes
***************

No phenotypes found linked to this gene.

.. _TRPM5 GO Term:

Gene Ontology
*************

* voltage-gated ion channel activity
* ion channel activity
* potassium channel activity
* calcium activated cation channel activity
* integral to membrane
* sodium channel activity
* plasma membrane

.. _TRPM5 Pathway:

KEGG Pathways
*************

* `Taste transduction <http://www.genome.jp/dbget-bin/show_pathway?hsa04742+29850>`_

.. _TRPM5 GeneRIF:

GeneRIFs
********

* understanding the structural basis for TRPM5 function will ultimately allow the design of pharmaceuticals to enhance or interfere with taste sensations--{REVIEW} [`PMID 17217064`_]
* common TRPM5 variants are likely to be associated with prediabetic phenotypes; and this may in turn contribute to the development of type 2 \ ``diabetes``\  mellitus [`PMID 21489577`_]
* regulation of TRPM5 by Ca2+ mediates sensory activation in the taste system [`PMID 14657398`_]
* results suggest TRPM5 may play a role in upregulating endogenous expression of TRPA1, that TRPA1 activation may be an additional trigger for co-expressed calcium-dependent ion channels such as TRPM5, and that TRPM5 may amplify responses to TRPA1 ligands [`PMID 21133676`_]
* TRPM5 gene is imprinted, with preferential expression from the paternal allele. [`PMID 10607831`_]
* data show that extracellular acidification acts through specific residues on transient receptor potential cation channel, subfamily M(TRPM5) to block conduction through two distinct but related mechanisms [`PMID 15731110`_]
* TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i [`PMID 14634208`_]
* Observational study of gene-disease association. (HuGE Navigator) [`PMID 20660057`_]

.. _PMID 17217064: http://www.ncbi.nlm.nih.gov/pubmed/17217064
.. _PMID 21489577: http://www.ncbi.nlm.nih.gov/pubmed/21489577
.. _PMID 14657398: http://www.ncbi.nlm.nih.gov/pubmed/14657398
.. _PMID 21133676: http://www.ncbi.nlm.nih.gov/pubmed/21133676
.. _PMID 10607831: http://www.ncbi.nlm.nih.gov/pubmed/10607831
.. _PMID 15731110: http://www.ncbi.nlm.nih.gov/pubmed/15731110
.. _PMID 14634208: http://www.ncbi.nlm.nih.gov/pubmed/14634208
.. _PMID 20660057: http://www.ncbi.nlm.nih.gov/pubmed/20660057

.. _TRPM5 Pubmed:

PubMed Articles
***************

*Recent articles:*

* Ketterer C et al. "Genetic variation within the TRPM5 locus associates with prediabetic phenotypes in subjects at increased risk for type 2 diabetes." Metabolism. 2011 Sep;60(9):1325-33. `PMID 21489577`_
* Buber MT et al. "Overexpression of human transient receptor potential M5 upregulates endogenous human transient receptor potential A1 in a stable HEK cell line." Assay Drug Dev Technol. 2010 Dec;8(6):695-702. `PMID 21133676`_
* Fushan AA et al. "Association between common variation in genes encoding sweet taste signaling components and human sucrose perception." Chem Senses. 2010 Sep;35(7):579-92. `PMID 20660057`_
* Hosgood HD 3rd et al. "Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity." Occup Environ Med. 2009 Dec;66(12):848-53. `PMID 19773279`_
* Liman ER et al. "TRPM5 and taste transduction." Handb Exp Pharmacol. 2007;(179):287-98. `PMID 17217064`_
* Clapham DE et al. "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels." Pharmacol Rev. 2005 Dec;57(4):427-50. `PMID 16382100`_
* Liu D et al. "Extracellular acid block and acid-enhanced inactivation of the Ca2+-activated cation channel TRPM5 involve residues in the S3-S4 and S5-S6 extracellular domains." J Biol Chem. 2005 May 27;280(21):20691-9. `PMID 15731110`_
* Prawitt D et al. "TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i." Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15166-71. `PMID 14634208`_
* Liu D et al. "Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5." Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15160-5. `PMID 14657398`_
* Strausberg RL et al. "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. `PMID 12477932`_

.. _PMID 16382100: http://www.ncbi.nlm.nih.gov/pubmed/16382100
.. _PMID 19773279: http://www.ncbi.nlm.nih.gov/pubmed/19773279
.. _PMID 14634208: http://www.ncbi.nlm.nih.gov/pubmed/14634208
.. _PMID 12477932: http://www.ncbi.nlm.nih.gov/pubmed/12477932
.. _PMID 21489577: http://www.ncbi.nlm.nih.gov/pubmed/21489577
.. _PMID 14657398: http://www.ncbi.nlm.nih.gov/pubmed/14657398
.. _PMID 21133676: http://www.ncbi.nlm.nih.gov/pubmed/21133676
.. _PMID 15731110: http://www.ncbi.nlm.nih.gov/pubmed/15731110
.. _PMID 17217064: http://www.ncbi.nlm.nih.gov/pubmed/17217064
.. _PMID 20660057: http://www.ncbi.nlm.nih.gov/pubmed/20660057

*Top Pubmed articles linked to gene TRPM5 matching any search term:* 

* Glendinning JI et al. "The role of T1r3 and Trpm5 in carbohydrate-induced obesity in mice." Physiol Behav. 2012 Aug 20;107(1):50-8. `PMID 22683548`_
* Tóth B et al. "Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents." Proc Natl Acad Sci U S A. 2012 Jul 30;. `PMID 22847436`_
* Kyriazis GA et al. "Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion." Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):E524-32. `PMID 22315413`_
* Ketterer C et al. "Genetic variation within the TRPM5 locus associates with prediabetic phenotypes in subjects at increased risk for type 2 diabetes." Metabolism. 2011 Sep;60(9):1325-33. `PMID 21489577`_
* Uchida K et al. "The role of thermosensitive TRP (transient receptor potential) channels in insulin secretion." Endocr J. 2011;58(12):1021-8. `PMID 21785227`_
* Colsoul B et al. "Transient receptor potential cation channels in pancreatic β cells." Rev Physiol Biochem Pharmacol. 2011;161:87-110. `PMID 21744203`_
* Guinamard R et al. "The non-selective monovalent cationic channels TRPM4 and TRPM5." Adv Exp Med Biol. 2011;704:147-71. `PMID 21290294`_
* Islam MS et al. "TRP channels of islets." Adv Exp Med Biol. 2011;704:811-30. `PMID 21290328`_
* Palmer RK et al. "Triphenylphosphine oxide is a potent and selective inhibitor of the transient receptor potential melastatin-5 ion channel." Assay Drug Dev Technol. 2010 Dec;8(6):703-13. `PMID 21158685`_
* Enklaar T et al. "Adding efficiency: the role of the CAN ion channels TRPM4 and TRPM5 in pancreatic islets." Islets. 2010 Sep-Oct;2(5):337-8. `PMID 21099334`_

.. _PMID 22683548: http://www.ncbi.nlm.nih.gov/pubmed/22683548
.. _PMID 21099334: http://www.ncbi.nlm.nih.gov/pubmed/21099334
.. _PMID 21290294: http://www.ncbi.nlm.nih.gov/pubmed/21290294
.. _PMID 21158685: http://www.ncbi.nlm.nih.gov/pubmed/21158685
.. _PMID 21290328: http://www.ncbi.nlm.nih.gov/pubmed/21290328
.. _PMID 21489577: http://www.ncbi.nlm.nih.gov/pubmed/21489577
.. _PMID 21785227: http://www.ncbi.nlm.nih.gov/pubmed/21785227
.. _PMID 22847436: http://www.ncbi.nlm.nih.gov/pubmed/22847436
.. _PMID 22315413: http://www.ncbi.nlm.nih.gov/pubmed/22315413
.. _PMID 21744203: http://www.ncbi.nlm.nih.gov/pubmed/21744203