.. _UNC45A:

UNC45A
^^^^^^

.. contents::
   :local:

General Information
*******************

:Full gene name: unc-45 homolog A (C. elegans)
:Entrez Gene ID: 55898
:Location: 15q26.1
:Synonyms: SMAP1, GCUNC-45, GCUNC45, GC-UNC45, IRO039700, SMAP-1
:Type: protein-coding

User SNPs
*********

SNPs given by the user that are near or inside this gene: 

+-----------+---------------+------------+
|    SNP    | Distance (bp) | Direction  |
+===========+===============+============+
| rs8042680 |     24014     | downstream |
+-----------+---------------+------------+

.. _UNC45A Gene summary:

NCBI Summary
************

UNC45A plays a role in cell proliferation and myoblast fusion, binds progesterone receptor (PGR; MIM 607311) and HSP90 (HSPCA; MIM 140571), and acts as a regulator of the progesterone receptor chaperoning pathway (Price et al., 2002 [PubMed 12356907]; Chadli et al., 2006 [PubMed 16478993]).[supplied by OMIM, Mar 2008]

.. _OMIM ID 611219
                        : http://omim.org/entry/611219
                        

.. _UNC45A OMIM Text:

OMIM
****

:OMIM ID: `OMIM ID 611219
                        `_


.. _UNC45A Phenotype:

NCBI Phenotypes
***************

No phenotypes found linked to this gene.

.. _UNC45A GO Term:

Gene Ontology
*************

* chaperone-mediated protein folding
* muscle organ development
* Hsp90 protein binding
* nucleus
* perinuclear region of cytoplasm
* cell differentiation

.. _UNC45A Pathway:

KEGG Pathways
*************

No pathways found linked to this gene.

.. _UNC45A GeneRIF:

GeneRIFs
********

* GCUNC45 is required for the normal cellular distribution of Hsp90beta, but not Hsp90alpha. [`PMID 18285346`_]
* elevated GC UNC-45 protein expression in ovarian carcinoma proliferation and metastasis. [`PMID 17872978`_]
* Affinity Capture-MS [`PMID 19615732`_]
* Affinity Capture-MS [`PMID 20562859`_]
* Affinity Capture-MS [`PMID 21906983`_]
* The authors found that UNC-45A is alternatively expressed at the mRNA and protein levels as two isoforms and that the two isoforms differ only by a proline-rich 15-amino-acid sequence near the amino-terminus. [`PMID 21802425`_]
* GCUNC-45 is a novel modulator of progesterone receptor chaperoning by hsp90. [`PMID 16478993`_]

.. _PMID 18285346: http://www.ncbi.nlm.nih.gov/pubmed/18285346
.. _PMID 17872978: http://www.ncbi.nlm.nih.gov/pubmed/17872978
.. _PMID 19615732: http://www.ncbi.nlm.nih.gov/pubmed/19615732
.. _PMID 20562859: http://www.ncbi.nlm.nih.gov/pubmed/20562859
.. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983
.. _PMID 21802425: http://www.ncbi.nlm.nih.gov/pubmed/21802425
.. _PMID 16478993: http://www.ncbi.nlm.nih.gov/pubmed/16478993

.. _UNC45A Pubmed:

PubMed Articles
***************

*Recent articles:*

* Kim W et al. "Systematic and quantitative assessment of the ubiquitin-modified proteome." Mol Cell. 2011 Oct 21;44(2):325-40. `PMID 21906983`_
* Wagner SA et al. "A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles." Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. `PMID 21890473`_
* Guo W et al. "Differential turnover of myosin chaperone UNC-45A isoforms increases in metastatic human breast cancer." J Mol Biol. 2011 Sep 23;412(3):365-78. `PMID 21802425`_
* Danielsen JM et al. "Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level." Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. `PMID 21139048`_
* Behrends C et al. "Network organization of the human autophagy system." Nature. 2010 Jul 1;466(7302):68-76. `PMID 20562859`_
* Sowa ME et al. "Defining the human deubiquitinating enzyme interaction landscape." Cell. 2009 Jul 23;138(2):389-403. `PMID 19615732`_
* Chadli A et al. "GCUNC45 is the first Hsp90 co-chaperone to show alpha/beta isoform specificity." J Biol Chem. 2008 Apr 11;283(15):9509-12. `PMID 18285346`_
* Bazzaro M et al. "Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility." Am J Pathol. 2007 Nov;171(5):1640-9. `PMID 17872978`_
* Ewing RM et al. "Large-scale mapping of human protein-protein interactions by mass spectrometry." Mol Syst Biol. 2007;3:89. `PMID 17353931`_
* Olsen JV et al. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Cell. 2006 Nov 3;127(3):635-48. `PMID 17081983`_

.. _PMID 21890473: http://www.ncbi.nlm.nih.gov/pubmed/21890473
.. _PMID 17081983: http://www.ncbi.nlm.nih.gov/pubmed/17081983
.. _PMID 17353931: http://www.ncbi.nlm.nih.gov/pubmed/17353931
.. _PMID 18285346: http://www.ncbi.nlm.nih.gov/pubmed/18285346
.. _PMID 21139048: http://www.ncbi.nlm.nih.gov/pubmed/21139048
.. _PMID 17872978: http://www.ncbi.nlm.nih.gov/pubmed/17872978
.. _PMID 19615732: http://www.ncbi.nlm.nih.gov/pubmed/19615732
.. _PMID 20562859: http://www.ncbi.nlm.nih.gov/pubmed/20562859
.. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983
.. _PMID 21802425: http://www.ncbi.nlm.nih.gov/pubmed/21802425