.. _VTI1A: VTI1A ^^^^^ .. contents:: :local: General Information ******************* :Full gene name: vesicle transport through interaction with t-SNAREs homolog 1A (yeast) :Entrez Gene ID: 143187 :Location: 10q25.2 :Synonyms: MVti1, Vti1-rp2, VTI1RP2 :Type: protein-coding User SNPs ********* SNPs given by the user that are near or inside this gene: +-----------+---------------+------------+ | SNP | Distance (bp) | Direction | +===========+===============+============+ | rs7903146 | 179845 | downstream | +-----------+---------------+------------+ .. _VTI1A Gene summary: NCBI Summary ************ None available. .. _OMIM ID 614316 : http://omim.org/entry/614316 .. _VTI1A OMIM Text: OMIM **** :OMIM ID: `OMIM ID 614316 `_ .. _VTI1A Phenotype: NCBI Phenotypes *************** * Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. * NHGRI GWA Catalog .. _VTI1A GO Term: Gene Ontology ************* * ER to Golgi vesicle-mediated transport * SNARE complex * vesicle fusion with Golgi apparatus * Golgi apparatus * SNAP receptor activity * Golgi membrane * neuronal cell body * retrograde transport, endosome to Golgi * integral to membrane * intracellular protein transport * synaptic vesicle .. _VTI1A Pathway: KEGG Pathways ************* * `SNARE interactions in vesicular transport `_ .. _VTI1A GeneRIF: GeneRIFs ******** * The present results suggest that a SNARE complex containing VAMP7 and Vti1a defines a novel traffic pathway to the cell surface in both neuronal and non-neuronal cells. [`PMID 19138172`_] * Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) [`PMID 20379614`_] * Affinity Capture-Western [`PMID 11101518`_] * Affinity Capture-Western; Co-purification [`PMID 11101518`_] * Affinity Capture-Western [`PMID 11101518`_] * Affinity Capture-Western [`PMID 11839770`_] * Affinity Capture-Western [`PMID 11839770`_] * Affinity Capture-MS; Reconstituted Complex [`PMID 21906983`_] * We found a colorectal carcinoma cell line harboring the fusion gene to be dependent on VTI1A-TCF7L2 for anchorage-independent growth using RNA interference-mediated knockdown. [`PMID 21892161`_] * Observational study of gene-disease association. (HuGE Navigator) [`PMID 19023099`_] .. _PMID 19138172: http://www.ncbi.nlm.nih.gov/pubmed/19138172 .. _PMID 20379614: http://www.ncbi.nlm.nih.gov/pubmed/20379614 .. _PMID 11101518: http://www.ncbi.nlm.nih.gov/pubmed/11101518 .. _PMID 11839770: http://www.ncbi.nlm.nih.gov/pubmed/11839770 .. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983 .. _PMID 21892161: http://www.ncbi.nlm.nih.gov/pubmed/21892161 .. _PMID 19023099: http://www.ncbi.nlm.nih.gov/pubmed/19023099 .. _VTI1A Pubmed: PubMed Articles *************** *Recent articles:* * Kim W et al. "Systematic and quantitative assessment of the ubiquitin-modified proteome." Mol Cell. 2011 Oct 21;44(2):325-40. `PMID 21906983`_ * Bass AJ et al. "Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion." Nat Genet. 2011 Sep 4;43(10):964-8. `PMID 21892161`_ * Danielsen JM et al. "Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level." Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. `PMID 21139048`_ * Sotoodehnia N et al. "Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction." Nat Genet. 2010 Dec;42(12):1068-76. `PMID 21076409`_ * Rose JE et al. "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." Mol Med. 2010 Jul-Aug;16(7-8):247-53. `PMID 20379614`_ * Nishimoto-Morita K et al. "Differential effects of depletion of ARL1 and ARFRP1 on membrane trafficking between the trans-Golgi network and endosomes." J Biol Chem. 2009 Apr 17;284(16):10583-92. `PMID 19224922`_ * Flowerdew SE et al. "A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels." Biochem J. 2009 Mar 15;418(3):529-40. `PMID 19138172`_ * Luke MM et al. "Gene variants associated with ischemic stroke: the cardiovascular health study." Stroke. 2009 Feb;40(2):363-8. `PMID 19023099`_ * Shiffman D et al. "Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study." Arterioscler Thromb Vasc Biol. 2008 Jan;28(1):173-9. `PMID 17975119`_ * Grupe A et al. "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease." Am J Hum Genet. 2006 Jan;78(1):78-88. `PMID 16385451`_ .. _PMID 17975119: http://www.ncbi.nlm.nih.gov/pubmed/17975119 .. _PMID 19138172: http://www.ncbi.nlm.nih.gov/pubmed/19138172 .. _PMID 21139048: http://www.ncbi.nlm.nih.gov/pubmed/21139048 .. _PMID 20379614: http://www.ncbi.nlm.nih.gov/pubmed/20379614 .. _PMID 19224922: http://www.ncbi.nlm.nih.gov/pubmed/19224922 .. _PMID 16385451: http://www.ncbi.nlm.nih.gov/pubmed/16385451 .. _PMID 19023099: http://www.ncbi.nlm.nih.gov/pubmed/19023099 .. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983 .. _PMID 21892161: http://www.ncbi.nlm.nih.gov/pubmed/21892161 .. _PMID 21076409: http://www.ncbi.nlm.nih.gov/pubmed/21076409 *Top Pubmed articles linked to gene VTI1A matching any search term:* * Behre CJ et al. "Dissociation between adipose tissue expression and serum levels of adiponectin during and after diet-induced weight loss in obese subjects with and without the metabolic syndrome." Metabolism. 2007 Aug;56(8):1022-8. `PMID 17618945`_ * Bose A et al. "The v-SNARE Vti1a regulates insulin-stimulated glucose transport and Acrp30 secretion in 3T3-L1 adipocytes." J Biol Chem. 2005 Nov 4;280(44):36946-51. `PMID 16131485`_ .. _PMID 17618945: http://www.ncbi.nlm.nih.gov/pubmed/17618945 .. _PMID 16131485: http://www.ncbi.nlm.nih.gov/pubmed/16131485