.. _ZBED3:

ZBED3
^^^^^

.. contents::
   :local:

General Information
*******************

:Full gene name: zinc finger, BED-type containing 3
:Entrez Gene ID: 84327
:Location: 5q13.3
:Synonyms: 
:Type: protein-coding

User SNPs
*********

SNPs given by the user that are near or inside this gene: 

+-----------+---------------+-----------+
|    SNP    | Distance (bp) | Direction |
+===========+===============+===========+
| rs4457053 |     41919     |  upstream |
+-----------+---------------+-----------+

.. _ZBED3 Gene summary:

NCBI Summary
************

None available.

.. _ZBED3 OMIM Text:

OMIM
****

No OMIM data available for this gene.

.. _ZBED3 Phenotype:

NCBI Phenotypes
***************

* Twelve type 2 \ ``diabetes``\  susceptibility loci identified through large-scale association analysis.
* NHGRI GWA Catalog

.. _ZBED3 GO Term:

Gene Ontology
*************

* DNA binding
* metal ion binding

.. _ZBED3 Pathway:

KEGG Pathways
*************

No pathways found linked to this gene.

.. _ZBED3 GeneRIF:

GeneRIFs
********

* Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) [`PMID 20889853`_]
* Zbed3 is a novel Axin-binding protein that is involved in Wnt/beta-catenin signaling modulation. [`PMID 19141611`_]

.. _PMID 20889853: http://www.ncbi.nlm.nih.gov/pubmed/20889853
.. _PMID 19141611: http://www.ncbi.nlm.nih.gov/pubmed/19141611

.. _ZBED3 Pubmed:

PubMed Articles
***************

*Recent articles:*

* de Miguel-Yanes JM et al. "Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms." Diabetes Care. 2011 Jan;34(1):121-5. `PMID 20889853`_
* Voight BF et al. "Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis." Nat Genet. 2010 Jul;42(7):579-89. `PMID 20581827`_
* Chen T et al. "Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling." J Biol Chem. 2009 Mar 13;284(11):6683-9. `PMID 19141611`_
* Gerhard DS et al. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 2004 Oct;14(10B):2121-7. `PMID 15489334`_
* Strausberg RL et al. "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. `PMID 12477932`_
* Maruyama K et al. "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides." Gene. 1994 Jan 28;138(1-2):171-4. `PMID 8125298`_

.. _PMID 20889853: http://www.ncbi.nlm.nih.gov/pubmed/20889853
.. _PMID 20581827: http://www.ncbi.nlm.nih.gov/pubmed/20581827
.. _PMID 12477932: http://www.ncbi.nlm.nih.gov/pubmed/12477932
.. _PMID 19141611: http://www.ncbi.nlm.nih.gov/pubmed/19141611
.. _PMID 8125298: http://www.ncbi.nlm.nih.gov/pubmed/8125298
.. _PMID 15489334: http://www.ncbi.nlm.nih.gov/pubmed/15489334

*Top Pubmed articles linked to gene ZBED3 matching any search term:* 

* Ohshige T et al. "Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese." PLoS One. 2011;6(10):e26911. `PMID 22046406`_
* Nielsen T et al. "Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release." Diabetologia. 2011 May;54(5):1052-6. `PMID 21267535`_
* de Miguel-Yanes JM et al. "Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms." Diabetes Care. 2011 Jan;34(1):121-5. `PMID 20889853`_
* Voight BF et al. "Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis." Nat Genet. 2010 Jul;42(7):579-89. `PMID 20581827`_

.. _PMID 22046406: http://www.ncbi.nlm.nih.gov/pubmed/22046406
.. _PMID 20889853: http://www.ncbi.nlm.nih.gov/pubmed/20889853
.. _PMID 20581827: http://www.ncbi.nlm.nih.gov/pubmed/20581827
.. _PMID 21267535: http://www.ncbi.nlm.nih.gov/pubmed/21267535