.. _ZFAND6: ZFAND6 ^^^^^^ .. contents:: :local: General Information ******************* :Full gene name: zinc finger, AN1-type domain 6 :Entrez Gene ID: 54469 :Location: 15q25.1 :Synonyms: AWP1, ZA20D3, ZFAND5B :Type: protein-coding User SNPs ********* SNPs given by the user that are near or inside this gene: +------------+---------------+------------+ | SNP | Distance (bp) | Direction | +============+===============+============+ | rs11634397 | 1512 | downstream | +------------+---------------+------------+ .. _ZFAND6 Gene summary: NCBI Summary ************ None available. .. _OMIM ID 610183 : http://omim.org/entry/610183 .. _ZFAND6 OMIM Text: OMIM **** :OMIM ID: `OMIM ID 610183 `_ .. _ZFAND6 Phenotype: NCBI Phenotypes *************** * Twelve type 2 \ ``diabetes``\ susceptibility loci identified through large-scale association analysis. * NHGRI GWA Catalog .. _ZFAND6 GO Term: Gene Ontology ************* * regulation of I-kappaB kinase/NF-kappaB cascade * polyubiquitin binding * molecular_function * cytoplasm * DNA binding * cellular_component * apoptotic process * zinc ion binding * regulation of apoptotic process * cellular response to tumor necrosis factor * protein targeting to peroxisome * biological_process .. _ZFAND6 Pathway: KEGG Pathways ************* No pathways found linked to this gene. .. _ZFAND6 GeneRIF: GeneRIFs ******** * Affinity Capture-MS [`PMID 21890473`_] * Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) [`PMID 20889853`_] * The AN1 domain of AWP1 mediated the functional interaction with tumor necrosis factor receptor-associated factor 2, and the A20 domain was responsible for the negative regulation of nuclear factor kappaB activation. [`PMID 21810480`_] * Affinity Capture-Western; Reconstituted Complex; Two-hybrid [`PMID 21810480`_] * Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) [`PMID 20549515`_] * Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) [`PMID 20379614`_] .. _PMID 21890473: http://www.ncbi.nlm.nih.gov/pubmed/21890473 .. _PMID 20889853: http://www.ncbi.nlm.nih.gov/pubmed/20889853 .. _PMID 21810480: http://www.ncbi.nlm.nih.gov/pubmed/21810480 .. _PMID 20549515: http://www.ncbi.nlm.nih.gov/pubmed/20549515 .. _PMID 20379614: http://www.ncbi.nlm.nih.gov/pubmed/20379614 .. _ZFAND6 Pubmed: PubMed Articles *************** *Recent articles:* * Chang EJ et al. "AWP1 binds to tumor necrosis factor receptor-associated factor 2 (TRAF2) and is involved in TRAF2-mediated nuclear factor-kappaB signaling." Int J Biochem Cell Biol. 2011 Nov;43(11):1612-20. `PMID 21810480`_ * Wagner SA et al. "A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles." Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. `PMID 21890473`_ * de Miguel-Yanes JM et al. "Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms." Diabetes Care. 2011 Jan;34(1):121-5. `PMID 20889853`_ * Feng T et al. "Genome-wide searching of rare genetic variants in WTCCC data." Hum Genet. 2010 Sep;128(3):269-80. `PMID 20549515`_ * Voight BF et al. "Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis." Nat Genet. 2010 Jul;42(7):579-89. `PMID 20581827`_ * Rose JE et al. "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." Mol Med. 2010 Jul-Aug;16(7-8):247-53. `PMID 20379614`_ * Kimura K et al. "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes." Genome Res. 2006 Jan;16(1):55-65. `PMID 16344560`_ * Rual JF et al. "Towards a proteome-scale map of the human protein-protein interaction network." Nature. 2005 Oct 20;437(7062):1173-8. `PMID 16189514`_ * Stelzl U et al. "A human protein-protein interaction network: a resource for annotating the proteome." Cell. 2005 Sep 23;122(6):957-68. `PMID 16169070`_ * Cao YK et al. "[Construction of GFP-AWP1 fusion gene vector and its expression in 293 cells]." Di Yi Jun Yi Da Xue Xue Bao. 2005 Feb;25(2):174-6, 180. `PMID 15698998`_ .. _PMID 21890473: http://www.ncbi.nlm.nih.gov/pubmed/21890473 .. _PMID 20889853: http://www.ncbi.nlm.nih.gov/pubmed/20889853 .. _PMID 21810480: http://www.ncbi.nlm.nih.gov/pubmed/21810480 .. _PMID 16189514: http://www.ncbi.nlm.nih.gov/pubmed/16189514 .. _PMID 20581827: http://www.ncbi.nlm.nih.gov/pubmed/20581827 .. _PMID 20379614: http://www.ncbi.nlm.nih.gov/pubmed/20379614 .. _PMID 15698998: http://www.ncbi.nlm.nih.gov/pubmed/15698998 .. _PMID 20549515: http://www.ncbi.nlm.nih.gov/pubmed/20549515 .. _PMID 16169070: http://www.ncbi.nlm.nih.gov/pubmed/16169070 .. _PMID 16344560: http://www.ncbi.nlm.nih.gov/pubmed/16344560 *Top Pubmed articles linked to gene ZFAND6 matching any search term:* * Ohshige T et al. "Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese." PLoS One. 2011;6(10):e26911. `PMID 22046406`_ * Nielsen T et al. "Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release." Diabetologia. 2011 May;54(5):1052-6. `PMID 21267535`_ * de Miguel-Yanes JM et al. "Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms." Diabetes Care. 2011 Jan;34(1):121-5. `PMID 20889853`_ * Feng T et al. "Genome-wide searching of rare genetic variants in WTCCC data." Hum Genet. 2010 Sep;128(3):269-80. `PMID 20549515`_ * Voight BF et al. "Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis." Nat Genet. 2010 Jul;42(7):579-89. `PMID 20581827`_ .. _PMID 22046406: http://www.ncbi.nlm.nih.gov/pubmed/22046406 .. _PMID 20889853: http://www.ncbi.nlm.nih.gov/pubmed/20889853 .. _PMID 20581827: http://www.ncbi.nlm.nih.gov/pubmed/20581827 .. _PMID 20549515: http://www.ncbi.nlm.nih.gov/pubmed/20549515 .. _PMID 21267535: http://www.ncbi.nlm.nih.gov/pubmed/21267535