ARAP1

General Information

Full gene name:ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 Entrez Gene ID:116985 Location:11q13.4 Synonyms:CENTD2 Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs1552224	0	within

NCBI Summary

The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

OMIM

OMIM ID:`OMIM ID 606646 `_

NCBI Phenotypes

• Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.
• Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
• NHGRI GWA Catalog
• Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

Gene Ontology

• Rho GTPase activator activity
• regulation of cellular component movement
• Golgi apparatus
• Golgi cisterna membrane
• cytosol
• protein binding
• regulation of cell shape
• actin filament reorganization involved in cell cycle
• negative regulation of stress fiber assembly
• zinc ion binding
• ARF GTPase activator activity
• phosphatidylinositol-3,4,5-trisphosphate binding
• positive regulation of Cdc42 GTPase activity
• regulation of ARF GTPase activity
• small GTPase mediated signal transduction
• positive regulation of filopodium assembly
• regulation of small GTPase mediated signal transduction
• plasma membrane

KEGG Pathways

• Endocytosis

GeneRIFs

• Affinity Capture-MS [PMID 21890473]
• Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) [PMID 20889853]
• ARAP1 acts primarily on Arf6 in vivo. [PMID 18003747]
• ARAP1 controls the late steps of the endocytic trafficking of the EGF-R [PMID 18764928]
• ARAP1 knockdown significantly compromises the localization of death receptor 4 at the cell surface of several tumor cell lines and slows down their TRAIL-induced death. [PMID 18165900]
• PTK6 enhances EGFR signaling by inhibition of EGFR down-regulation through phosphorylation of ARAP1 in breast cancer cells. [PMID 20554524]
• Two-hybrid [PMID 21900206]
• ARAP1 associated with CIN85 affects epidermal growth factor receptor endocytic trafficking [PMID 21275903]
• Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid [PMID 21275903]
• Two-hybrid [PMID 21275903]
• Two-hybrid [PMID 21275903]
• Two-hybrid [PMID 21275903]
• Two-hybrid [PMID 21275903]
• Two-hybrid [PMID 21275903]
• Two-hybrid [PMID 21275903]
• ARAP1 regulates the endocytic traffic of EGFR and, consequently, the rate of EGFR signal attenuation [PMID 18939958]
• Arap1 is highly expressed in the renal vasculature, and its expression is suppressed by angiotensin II. [PMID 22357923]
• Of the lead variants from 12 novel type 2 diabetes associated loci, CENTD2 significantly associated with increased plasma glucose values and decreased glucose-stimulated insulin release. [PMID 21267535]
• Affinity Capture-MS [PMID 20360068]
• Two-hybrid [PMID 16169070]
• Two-hybrid [PMID 16169070]
• Two-hybrid [PMID 16169070]
• Two-hybrid [PMID 16169070]
• Data suggest that ARAP1 is recruited to membranes independently of PtdIns(3,4,5)P(3), the subsequent production of which triggers enzymatic activity. [PMID 19666464]
• NS5A interacts with CENT-delta-2. [PMID 15607035]

PubMed Articles

Recent articles:

• Doblinger E et al. “Angiotensin AT1 receptor-associated protein Arap1 in the kidney vasculature is suppressed by angiotensin II.” Am J Physiol Renal Physiol. 2012 May;302(10):F1313-24. PMID 22357923
• Okada Y et al. “Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.” Nat Genet. 2012 Mar 25;44(5):511-6. PMID 22446963
• Wagner SA et al. “A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.” Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. PMID 21890473
• Strawbridge RJ et al. “Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.” Diabetes. 2011 Oct;60(10):2624-34. PMID 21873549
• Vinayagam A et al. “A directed protein interaction network for investigating intracellular signal transduction.” Sci Signal. 2011 Sep 6;4(189):rs8. PMID 21900206
• Nielsen T et al. “Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release.” Diabetologia. 2011 May;54(5):1052-6. PMID 21267535
• Yoon HY et al. “ARAP1 association with CIN85 affects epidermal growth factor receptor endocytic trafficking.” Biol Cell. 2011 Apr;103(4):171-84. PMID 21275903
• Danielsen JM et al. “Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.” Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. PMID 21139048
• de Miguel-Yanes JM et al. “Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.” Diabetes Care. 2011 Jan;34(1):121-5. PMID 20889853
• Voight BF et al. “Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.” Nat Genet. 2010 Jul;42(7):579-89. PMID 20581827

Top Pubmed articles linked to gene ARAP1 matching any search term:

• Johansson S et al. “Exome sequencing and genetic testing for MODY.” PLoS One. 2012;7(5):e38050. PMID 22662265
• Bao XY et al. “Replication study of novel risk variants in six genes with type 2 diabetes and related quantitative traits in the Han Chinese lean individuals.” Mol Biol Rep. 2012 Mar;39(3):2447-54. PMID 21643948
• Strawbridge RJ et al. “Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.” Diabetes. 2011 Oct;60(10):2624-34. PMID 21873549
• Nielsen T et al. “Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release.” Diabetologia. 2011 May;54(5):1052-6. PMID 21267535
• de Miguel-Yanes JM et al. “Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.” Diabetes Care. 2011 Jan;34(1):121-5. PMID 20889853
• Voight BF et al. “Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.” Nat Genet. 2010 Jul;42(7):579-89. PMID 20581827