The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]
Recent articles:
- Green MF et al. “Characterization of the CaMKKβ-AMPK signaling complex.” Cell Signal. 2011 Dec;23(12):2005-12. PMID 21807092
- Cao W et al. “Differential effects of PKA-controlled CaMKK2 variants on neuronal differentiation.” RNA Biol. 2011 Nov-Dec;8(6):1061-72. PMID 21957496
- Kim W et al. “Systematic and quantitative assessment of the ubiquitin-modified proteome.” Mol Cell. 2011 Oct 21;44(2):325-40. PMID 21906983
- Wagner SA et al. “A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.” Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. PMID 21890473
- Mungai PT et al. “Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels.” Mol Cell Biol. 2011 Sep;31(17):3531-45. PMID 21670147
- Green MF et al. “Ca2+/Calmodulin-dependent protein kinase kinase beta is regulated by multisite phosphorylation.” J Biol Chem. 2011 Aug 12;286(32):28066-79. PMID 21669867
- McArdle J et al. “Inhibition of calmodulin-dependent kinase kinase blocks human cytomegalovirus-induced glycolytic activation and severely attenuates production of viral progeny.” J Virol. 2011 Jan;85(2):705-14. PMID 21084482
- Behrends C et al. “Network organization of the human autophagy system.” Nature. 2010 Jul 1;466(7302):68-76. PMID 20562859
- Rose JE et al. “Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.” Mol Med. 2010 Jul-Aug;16(7-8):247-53. PMID 20379614
- Kimura T et al. “Mechanism and role of high density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells.” J Biol Chem. 2010 Feb 12;285(7):4387-97. PMID 20018878
Top Pubmed articles linked to gene CAMKK2 matching any search term:
- Racioppi L et al. “Calcium/Calmodulin-dependent Protein Kinase Kinase 2 Regulates Macrophage-mediated Inflammatory Responses.” J Biol Chem. 2012 Mar 30;287(14):11579-91. PMID 22334678
- Anderson KA et al. “Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse.” Mol Endocrinol. 2012 Feb;26(2):281-91. PMID 22240810
- Beck A et al. “An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of cytokine-induced death of pancreatic beta cells.” Diabetologia. 2011 Nov;54(11):2845-55. PMID 21853325
- Chikahisa S et al. “Central AMPK contributes to sleep homeostasis in mice.” Neuropharmacology. 2009 Sep;57(4):369-74. PMID 19615388
- Anderson KA et al. “Hypothalamic CaMKK2 contributes to the regulation of energy balance.” Cell Metab. 2008 May;7(5):377-88. PMID 18460329
- Imai S et al. “Increased intracellular calcium activates serum and glucocorticoid-inducible kinase 1 (SGK1) through a calmodulin-calcium calmodulin dependent kinase kinase pathway in Chinese hamster ovary cells.” Life Sci. 2003 Apr 4;72(20):2199-209. PMID 12628440