CCNE2

General Information

Full gene name:cyclin E2 Entrez Gene ID:9134 Location:8q22.1 Synonyms:CYCE2 Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs896854	53029	upstream

NCBI Summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]

OMIM

OMIM ID:`OMIM ID 603775 `_

NCBI Phenotypes

No phenotypes found linked to this gene.

Gene Ontology

• mitotic cell cycle
• regulation of cyclin-dependent protein kinase activity
• protein kinase binding
• G1/S transition of mitotic cell cycle
• protein binding
• cell division
• cytosol
• nucleoplasm
• cell cycle checkpoint

KEGG Pathways

• Prostate cancer
• Cell cycle
• Measles
• Small cell lung cancer
• Pathways in cancer
• Oocyte meiosis
• p53 signaling pathway

GeneRIFs

• Observational study of gene-disease association. (HuGE Navigator) [PMID 19738611]
• Affinity Capture-Western; Biochemical Activity [PMID 9840927]
• Affinity Capture-Western [PMID 9840927]
• Affinity Capture-Western [PMID 9840927]
• Affinity Capture-Western [PMID 9858585]
• Since SCF(Fbxw7/hCdc4) is functionally inactivated in several cancer types, alteration of this molecular pathway could contribute to the deregulation of cyclin E2 in tumorigenesis. [PMID 19084516]
• Affinity Capture-Western; Biochemical Activity [PMID 19084516]
• The CCNE2 qualify as independent prognostic markers for lymph node-negative breast cancer patients. [PMID 16740753]
• Tamoxifen resistant tumors displayed enriched expression of genes related to cell cycle and proliferation, as well as elevated activity of E2F transcription factors. [PMID 21789246]
• protein and mRNA expressions of Cyclin E2 in nasopharyngeal carcinoma [PMID 22394640]
• A hypothetical model whereby PTEN loss upregulates cell cycle genes such as cdc6 and cyclin E2 that in turn promote metastatic colonization at distant sites. [PMID 19107233]
• Affinity Capture-MS [PMID 16620772]
• Affinity Capture-MS [PMID 16620772]
• Data indicate that cyclin E2-Cdk2 activation by estrogen occurs via E2F- and CHD8-mediated transcription of cyclin E2 downstream of cyclin D1, and does not require c-myc. [PMID 19564413]
• Loss of cyclin D1 in ovarian cancer cells treated with SHetA2 is sufficient to induce G(1) cell cycle arrest and this strategy is not impeded by the presence of cyclin E2. [PMID 19638577]
• Investigated downregulation of coronary vascular smooth muscle cell growth by siRNA against E2F1, cyclins E1 and E2. Data shows reduction in the phosphorylation levels of the retinoblastoma protein pRB and a decrease in the amount of cyclin A2. [PMID 19603101]
• Affinity Capture-MS; Affinity Capture-Western [PMID 15717329]
• Affinity Capture-MS; Affinity Capture-Western [PMID 21906983]
• expression is deregulated in primary breast tumors [PMID 12466974]

PubMed Articles

Recent articles:

• Zhao GH et al. “[Expression and clinical significance of cyclin E2 in nasopharyngeal carcinoma].” Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012 Mar;28(3):291-3. PMID 22394640
• Kim W et al. “Systematic and quantitative assessment of the ubiquitin-modified proteome.” Mol Cell. 2011 Oct 21;44(2):325-40. PMID 21906983
• Huang L et al. “An integrated bioinformatics approach identifies elevated cyclin E2 expression and E2F activity as distinct features of tamoxifen resistant breast tumors.” PLoS One. 2011;6(7):e22274. PMID 21789246
• Cunningham JM et al. “Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.” Br J Cancer. 2009 Oct 20;101(8):1461-8. PMID 19738611
• Caldon CE et al. “Estrogen regulation of cyclin E2 requires cyclin D1 but not c-Myc.” Mol Cell Biol. 2009 Sep;29(17):4623-39. PMID 19564413
• Masamha CP et al. “Cyclin D1 degradation is sufficient to induce G1 cell cycle arrest despite constitutive expression of cyclin E2 in ovarian cancer cells.” Cancer Res. 2009 Aug 15;69(16):6565-72. PMID 19638577
• Klotz K et al. “SCF(Fbxw7/hCdc4) targets cyclin E2 for ubiquitin-dependent proteolysis.” Exp Cell Res. 2009 Jul 1;315(11):1832-9. PMID 19084516
• Dapas B et al. “Role of E2F1-cyclin E1-cyclin E2 circuit in human coronary smooth muscle cell proliferation and therapeutic potential of its downregulation by siRNAs.” Mol Med. 2009 Sep-Oct;15(9-10):297-306. PMID 19603101
• Wu Z et al. “Cdc6 and cyclin E2 are PTEN-regulated genes associated with human prostate cancer metastasis.” Neoplasia. 2009 Jan;11(1):66-76. PMID 19107233
• Grimmler M et al. “Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases.” Cell. 2007 Jan 26;128(2):269-80. PMID 17254966

Top Pubmed articles linked to gene CCNE2 matching any search term:

• Borradaile NM et al. “Polyploidy impairs human aortic endothelial cell function and is prevented by nicotinamide phosphoribosyltransferase.” Am J Physiol Cell Physiol. 2010 Jan;298(1):C66-74. PMID 19846757
• Dapas B et al. “Role of E2F1-cyclin E1-cyclin E2 circuit in human coronary smooth muscle cell proliferation and therapeutic potential of its downregulation by siRNAs.” Mol Med. 2009 Sep-Oct;15(9-10):297-306. PMID 19603101