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CDKN2B

General Information

Full gene name:cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
Entrez Gene ID:1030
Location:9p21
Synonyms:MTS2, TP15, P15, p15INK4b, CDK4I, INK4B
Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP Distance (bp) Direction
rs10811661 124782 upstream

NCBI Summary

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

OMIM

OMIM ID:`OMIM ID 613149 `_

NCBI Phenotypes

  • Genome-wide association study identifies five new breast cancer susceptibility loci.
  • Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction.
  • Genome-wide association study of coronary artery disease in the Japanese.
  • Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
  • A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.
  • Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
  • Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
  • A genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucoma.
  • Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
  • Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
  • Genome-wide association study identifies five susceptibility loci for glioma.
  • Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies.
  • A common variant on chromosome 9p21 affects the risk of myocardial infarction.
  • Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas.
  • Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
  • Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
  • Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
  • 1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data.
  • Chromosome 7p11.2 (EGFR) variation influences glioma risk.
  • A genome-wide association study of optic disc parameters.
  • NHGRI GWA Catalog
  • Susceptibility loci for intracranial aneurysm in European and Japanese populations.
  • Genome-wide association study of intracranial aneurysm identifies three new risk loci.
  • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
  • A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.

Gene Ontology

  • mitotic cell cycle
  • cell cycle arrest
  • cytosol
  • cytoplasm
  • positive regulation of epithelial cell differentiation
  • megakaryocyte differentiation
  • response to organic cyclic compound
  • negative regulation of cell proliferation
  • mitotic cell cycle G1/S transition checkpoint
  • positive regulation of transforming growth factor beta receptor signaling pathway
  • protein binding
  • cyclin-dependent protein kinase inhibitor activity
  • negative regulation of phosphorylation
  • cellular response to extracellular stimulus
  • nucleus
  • cellular response to nutrient
  • negative regulation of epithelial cell proliferation
  • response to cytokine stimulus
  • G1 phase of mitotic cell cycle
  • regulation of cyclin-dependent protein kinase activity
  • protein kinase binding
  • G2/M transition of mitotic cell cycle

GeneRIFs

  • transition to increased aggressiveness in melanoma cells requires Id2 upregulation to suppress TGF-beta induction of p15(Ink4b) and thus help to circumvent TGF-beta-mediated inhibition of proliferation. [PMID 19368689]
  • TGF-beta1 and/or TGF-beta2 inhibit proliferation of primary cultured human limbal epithelial cells, and p57 and p15 play roles in this process. [PMID 16943770]
  • comprehensive analysis of the deletion and the methylation profile of CDKN2A (hereafter identified separately as p16 and p14, for the different proteins encoded) and CDKN2B (hereafter p15) in 91 newly diagnosed B-ALL patients (61 children, 30 adults). [PMID 19837270]
  • investigation of the involvement of the CDKN2A, CDKN2B and p53 genes in actinic keratosis (AK) and in the progression of AK to squamous cell carcinoma [PMID 18331779]
  • Data show that the rs10811661 polymorphism near the CDKN2B/CDKN2A genes is associated with impaired insulin release and IGT, suggesting that this variant may contribute to type 2 diabetes by affecting beta cell function. [PMID 21234743]
  • A single SNP within the CDKN2B was common conveyed protection against coronary artery disease and was replicated in a combined analysis of two additional case/control studies of prevalent CAD/MI in African Americans [PMID 21270820]
  • Heavy p15INK4b methylation in myelodysplastic syndromes is associated with International Prognostic Scoring system predictors of poor prognosis and adverse survival. [PMID 19782398]
  • Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) [PMID 21048031]
  • Detection of epigenetic alterations allows the identification of patients with ALL with standard risk but with poor prognosis. [PMID 19109226]
  • senescence-responsive regulation of gene expression [PMID 19409979]
  • balance between Polycomb group (PcG) silencing and SWI/SNF activation affects epigenetic control of the INK4b-ARF-INK4a locus in malignant rhabdoid tumors [PMID 18332116]
  • induction of p15(INK4b) by inhibition of the MAPK/ERK pathway is associated with the antiproliferative effects of ZD1839 [PMID 17513607]
  • Type 2 diabetes susceptibility of CDKN2B was confirmed in Japanese. [PMID 19033397]
  • Study show that polymorphisms in CDKN2B were associated with type 2 diabetes risk in the studied population. [PMID 18694974]
  • TGFbeta recruited acetylase p300 to acetylate KLF5, and acetylation in turn altered the binding of KLF5 to p15 promoter, resulting in the reversal of KLF5 function. [PMID 19056724]
  • The methylation frequency in malignant pleural mesothelioma was 19%. Methylation did not correlate to outcome but to improved survival in unmethylated malignant pleural mesothelioma with extrapleural pneumonectomy. [PMID 17920725]
  • Genetic variation at the CDKN2A/CDKN2B locus predicts stroke in hypertensive patients. [PMID 19293724]
  • Methylation inactivation of P15 is associated with oral cancer [PMID 12684640]
  • Novel mutation of the cyclin-dependent kinase 4 gene was found in a Chinese patient with intimal sarcoma of the pulmonary artery [PMID 19493449]
  • there is an association between PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 and type 2 diabetes in the Chinese population [PMID 19862325]
  • Suggest that several atherosclerosis-associated SNPs in the 9p21 locus affect the expression of ANRIL, which, in turn modulate cell growth, possibly via CDKN2A/B regulation. [PMID 22178423]
  • There is more frequent p16 hypermethylation in mantle cell lymphoma and p15 or Rb1 hypermethylation in follicular lymphoma [PMID 17900658]
  • mechanisms of inactivation of p14(ARF), p15(INK4b), and p16(INK4a) in liver fluke-related cholangiocarcinoma are preferentially different, p16(INK4a) inactivation occurs through both genetic and epigenetic events. [PMID 19200577]
  • Up-regulation of p15(INK4b) by trichostatin A is associated with cell growth inhibition of HCT116 p21 (-/-) cells. [PMID 14623092]
  • Gfi-1 and c-Myc are both recruited to the CDKN2B core promoter and act in collaboration to repress CDKN2B [PMID 19164764]
  • Transcriptional repression of the p15 gene by dna methylation is associated with adult acute leukemia [PMID 15755508]
  • Expression of p15, p18 and p27 was not generally related to the MEN1 gene mutational status of the investigated 18 pancreatic endocrine tumours. [PMID 17803708]
  • High frequency of hypermethylation of p15 was detected in the pre-cancerous lesions; no hypermethylation was found in normal epithelium. Hypermethylation may be involved in the pathogenesis of oral precancerous lesions associated with betel-quid chewing. [PMID 18284544]
  • AID-mediated genotoxic effects appear to occur frequently at the CDKN2b-CDKN2a locus and contribute to malignant transformation of the gastric mucosa [PMID 20637757]
  • Homozygous deletions were found in exon 2 of the p15INK4b gene in human nervous system tumors. [PMID 18551412]
  • Epigenetic regulation of the INK4b-ARF-INK4a locus: in sickness and in health. [PMID 20716961]
  • Similar to T-ALL, p15INK4B mRNA was absent in 13 of 14 T-cell lymphoblastic lymphoma/leukemia biopsies and its promoter methylated in 6 of 10 (64%) cases [PMID 15475071]
  • Compared with normal colonic mucosa, in which virtually no p16 expression was observed, p16 was overexpressed in hyperplastic polyps (33%:2/6) adenomas (46%:27/59), carcinoma in adenoma (88%:7/8) and in adenocarcinomas (98%:82/84). [PMID 14696398]
  • Deletion analysis of p16(INKa) and p15(INKb) in relapsed childhood acute lymphoblastic leukemia. [PMID 12036898]
  • Methylation of p15INK4B is associated with myelodysplasia and acute myeloid leukemia. [PMID 12970781]
  • Aberrant methylation of multiple genes (E-cadherin, estrogen receptor, RB1 , p16, p15, p14, and MGMT) is involved in gastric carcinogenesis. [PMID 17652530]
  • results demonstrate a different expression profile between p16(INK4a) and p14(ARF), p15(INK4b) and p53 in BCC and a low percentage of LOH and of a polymorphic sequence variant (Ala148Thr) for the CDKN2A locus. [PMID 19298278]
  • Homozygous CDKN2A/p14(ARF)/CDKN2B deletion plays an important role in pleomorphic xanthoastrocytoma. [PMID 16909113]
  • CDKN2B (chromosome 9p) has been examined for loss of heterozygosity and is associated with a favorable treatment response in patients with T-cell lymphoblastic leukemia. [PMID 19586936]
  • Losses of INK4a/INK4b gene products play a big role in meningioma formation & malignant progression. Inactivation of p16/p15 and pl4ARF pendent pathways possibly along with telomerase activation might be critical for meningioma immortalization. [PMID 11859969]
  • Thus, high glucose-induced growth arrest is dependent on p15(INK4b) and oxidative stress in endothelial cells. [PMID 17597576]
  • 2 genes of loss, CDKN2B and PTCH1, are associated with poor overall survival in patients with squamous cell carcinoma of the lung and may be useful as prognostic markers [PMID 21889114]
  • all RARS patients had a methylated p15(INK4b) promoter correlating with non-detectable expression of this gene in bone marrow cells from those patients. [PMID 16682076]
  • rs4977756, a genetic variant of CDKN2B and CDKN2A, was one of 3 genetic variants implicated in a pool of US epidemiologic studies of glioma risk [PMID 21920947]
  • p15INK4B promoter methylation is associated with glioblastoma. [PMID 19424593]
  • findings indicate that the inactivation of the CDKN2A/B locus is a frequent event in Ph+ acute lymphoblastic leukemia; deletions are frequently acquired at leukemia progression and are a poor prognostic marker [PMID 22134481]
  • cases with inactivation of all p14(ARF), p15(INK4b), and p16(INK4a) genes showed the worst prognosis in a combined prognostic assessment [PMID 21262917]
  • Two-hybrid [PMID 16189514]
  • A 25-fold and fourfold increase of CDKN2BAS gene expression in gingival fibroblast (p=0.003) and cultured gingival epithelial cells (p=0.004), respectively, was observed after stimulation with Porphyromonas gingivalis in Streptococcus gordonii . [PMID 20978019]
  • Comprehensive analysis of the 9p21 locus including the CDKN2A, ARF, and CDKN2B genes in 53 individuals from melanoma index cases considered to be at heightened risk of melanoma [PMID 15937071]
  • Observational study of gene-disease association. (HuGE Navigator) [PMID 20971364]
  • Single nucleotide polymorphism in CDKN2B is associated with type 2 diabetes. [PMID 18991055]
  • These results establish the ZNF217 complex as a novel negative regulator of the p15(ink4b) gene and may constitute an important link between amplification of ZNF217 and the loss of TGF-beta responsiveness in breast cancer. [PMID 18625718]
  • A method of detecting deletions in the INK4B gene is described in detail. [PMID 11692873]
  • Inactivation of tumor suppressor genes p15(INK4b) and p16(INK4a) in primary cutaneous B cell lymphoma. [PMID 12060387]
  • Expression and methylation of CpG islands in the promoter of p15INK4B gene in children with acute myeloid leukemia. [PMID 15833197]
  • P15(INK4b) was found positive in 81 and 33% normal, 46 and 10% nodular hyperplasia, 74 and 36% PIN tissues, 87 and 89% low-grade carcinomas, and 100 and 93% high-grade carcinomas. [PMID 16799475]
  • Hypermethylation of the p15INK4b gene promoter in B-chronic lymphocytic leukemia was studied. [PMID 17546638]
  • We did not find p16, p14, and p57 to be useful as prognostic markers in stage III ovarian cancer [PMID 17885492]
  • Meta-analysis and HuGE review of gene-disease association. (HuGE Navigator) [PMID 19602701]
  • Promoter hypermethylation of CDKN2B was a consistent epigenetic event in sinonasal papillomas. [PMID 17673925]
  • Results suggest that methylation of the p15(INK4B) and p16(INK4A) genes is an epigenetic biomarker of pediatric disease evolution. [PMID 20658957]
  • Association study of common variation spanning the CDKN2A/CDKN2B locus confirms the strong association between the distal susceptibility variant and type 2 diabetes in the French population. [PMID 18368387]
  • Acute myeloid leukemia cells with p15INK4b DNA methylation have an altered histone methylation pattern compared with unmethylated samples. [PMID 20190193]
  • Miz1 interacts with p-p15Ink4b. [PMID 15580267]
  • CDKIs mediate growth arrest in human osteosarcoma cell lines and provides further evidence of the existence of molecular links between cellular mortality and immortality. [PMID 11695244]
  • Six SNP(rs7754840 in CDKAL1, rs391300 in SRR, rs2383208 in CDKN2A/2B, rs4402960 in IGF2BP2, rs10830963 in MTNR1B, rs4607517 in GCK)risk alleles of type 2 diabetes were associated with GDM in pregnant Chinese women. [PMID 22096510]
  • Two-hybrid [PMID 16169070]
  • Two-hybrid [PMID 16169070]
  • Two-hybrid [PMID 16169070]
  • Two-hybrid [PMID 16169070]
  • Inacativaton of this cell cycle regulatory genes by DNA methylation could be associated with tumorigenesis in NK cell disorders. [PMID 15813917]
  • Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) [PMID 20549515]
  • This study demonstrates for the first time that polymorphisms in CDKN2B and MTAP gene may influence the risk of myocardial infarction in Chinese. [PMID 19272367]
  • Valproate induces demethylation of p15 INK4B gene by inhibiting DNMT-1 and DNMT3B gene activities, which up-regulates p15 in Molt-4 cells. [PMID 19099629]
  • DNA sequence analysis of the breakpoints and junctions of CDKN2A and CDKN2B gene deletions in diffuse large B-cell lymphomas [PMID 21638516]
  • Perturbed modifications of histone H3 around the p15 CpG island region is associated with acute myeloblastic leukemia [PMID 17074388]
  • The absence of p15(INK4b) expression in the majority of tissue microarray cores of cutaneous SCC indicated that p15(INK4b) could possibly be involved in the pathogenesis of cutaneous SCC. [PMID 18564286]
  • Frequent abnormalities of the p15 gene in mycosis fungoides and sezary syndrome.polymorphisms promoter methylation [PMID 11874489]
  • The results of this study suggested that CDKN2A and CDKN2B do not act as a risk factors for Alzheimer’s disease. [PMID 21069533]
  • Strategies to re-express epigenetically silenced p15(INK4b) and p21(WAF1) genes in acute myeloid leukemia. [PMID 21124069]
  • Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) [PMID 20548946]
  • Findings suggest methylation of p15 INK4B as early events in the pathogenesis and development of plasma cell disorders. [PMID 19727727]
  • Data show that methylation of at least one gene was detected in 18 patients (45%), the genes methylated were CDKN2B (20%), RASSF1 (18%), RARB (10%), CDH13 (7.5%) and FHIT (5%). [PMID 20864173]
  • Two-hybrid [PMID 21900206]
  • Strengthened signals in imputation-based analysis at CDKN2B SNP rs3731239 lends evidence to the role of cell cycle genes in ovarian cancer etiology. [PMID 19258477]
  • Increased methylation of CDKN2B gene is associated with myelodysplastic syndromes and acute myeloid leukemia. [PMID 22248274]
  • results suggest a model in which ANRIL binds to and recruits PRC2 to repress the expression of p15(INK4B) locus [PMID 21151178]
  • The results indicate that in Chinese Hans, common variants in CDKN2B loci independently or additively contribute to type 2 diabetes risk, likely mediated through beta-cell dysfunction. [PMID 18633108]
  • Inactivation of p16/CDKN2 and p15/MTS2 is associated with prognosis and response to chemotherapy in ovarian cancer. [PMID 11992549]
  • Observational study and meta-analysis of gene-disease association. (HuGE Navigator) [PMID 20490451]
  • Hypermethylation of CDKN2B is associated with acute lymphoblastic leukemia of childhood. [PMID 19484265]
  • Expression of a novel, circular ANRIL isoforms (cANRIL) is correlated with INK4/ARF transcription and atherosclerosis risk. [PMID 21151960]
  • As2O3 treatment caused demethylation associated with an increase in mRNA levels of the CDKN2B and CDKN2A genes. [PMID 20596618]
  • Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) [PMID 20889853]
  • Cyclin-dependent kinase inhibitor p15INK4B plays an important role in activin-induced cell cycle arrest in liver cells. [PMID 15093610]
  • Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator) [PMID 20075150]
  • The P15 was methylated in 3 (15%) pediatric patients , compared to 16 (30%)respectively in adult patients. [PMID 15978938]
  • Results describe the significance of p16INK4A and p15INK5B transcription suppression with hypermethylation of their genes’ 5’CpG islands during human hepatocellular carcinogenesis. [PMID 15112341]
  • The correlation between P15(INK4B) promoter methylation and parvovirus B19 infection was observed in adult acute leukemia patients [PMID 18384396]
  • Studies identified significant association between variants in CDKN2A/B, CDKAL1 and TCF7L2, and type 2 diabetes in a Han Chinese cohort, indicating these genes as strong candidates conferring susceptibility to type 2 diabetes across different ethnicities. [PMID 20161779]
  • Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator) [PMID 19578367]
  • Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) [PMID 20879858]
  • CDKN2A CDKN2B and ANRIL is the susceptibility locus for coronary heart disease (CHD) and periodontitis. [PMID 19214202]
  • Results suggest that epigenetic alterations in p15INK4b have an important role in ovarian carcinogenesis and that mechanisms other than methylation may exist to reduce gene expression of p15INK4b in ovarian cancer. [PMID 16000597]
  • The variable expression levels of cell-cycle inhibitor genes CDKN2A, CDKN2B, and CDKN1B due to regulatory polymorphisms could indeed influence the risk of childhood pre-B ALL and contribute to carcinogenesis. [PMID 17008550]
  • Single nucleotide polymorphisms in CDKN2B is associated with Philadelphia positive acute lymphoblastic leukemia. [PMID 21414664]
  • On 9p21, rs1412829 near CDKN2B had discovery P = 3.4 x 10(-8), replication P = 0.0038 and combined P = 1.85 x 10(-10). On 20q13.3, rs6010620 intronic to RTEL1 had discovery P = 1.5 x 10(-7), replication P = 0.00035 and combined P = 3.40 x 10(-9). [PMID 19578366]
  • Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) [PMID 20628086]
  • the genetic status of the CDKN2A-CDKN2B locus would be relevant in assessing patients with epidermotropic cutaneous T-cell lymphomas [PMID 20118908]
  • Variations confer impaired glucose- and tolbutamide-induced insulin release in middle-aged and young healthy subjects. [PMID 17827400]
  • Inactivation of CDKN2A and B genes constitute an important step in chordoma development. [PMID 18071362]
  • Our results suggest that methylation of the p15(INK4b) gene contributes to the process of carcinogenesis in colorectal cancer as well as p16(INK4a) and is useful as a prognostic factor in the early stage [PMID 16872319]
  • p15 loss may be a critical event in tumorigenesis triggered by complex DNA double-strand breaks (DSBs). [PMID 20663777]
  • PKCalpha is specifically required for TPA-induced ERK(MAPK) signaling to trigger gene expressions of p15(INK4b) and p16(INK4a) leading to HepG2 growth inhibition [PMID 15917995]
  • Tumor suppressor genes p15(INK4b), p14(ARF) and p16(INK4a) are located at the 9p21 locus in 26 cryopreserved neurofibromatosis type 1-related malignant peripheral nerve sheath tumors. [PMID 14519636]
  • Data show that deletion of CDKN2A and CDKN2B as well as the sequences just upstream and downstream were confirmed in SCC. [PMID 21757289]
  • Observational study of genotype prevalence and gene-disease association. (HuGE Navigator) [PMID 11668523]
  • Data show that the high sensitivity of MS-qFRET enables one-step detection of methylation at PYCARD, CDKN2B, and CDKN2A genes in patient sputum samples that contain low concentrations of methylated DNA, which normally would require a nested PCR approach. [PMID 19443857]
  • p15(INK4b), rather than p27(KIP1), is the cyclin-dependent kinase inhibitor responsible for G0/G1 arrest of human melanoma cells grown on fibrillar collagen [PMID 17553787]
  • Oct-1 is an important transcriptional repressor for p15(INK4b) gene and the transcriptional repression of the p15(INK4b) gene by Oct-1 may be one of the regulatory mechanisms of cellular senescence. [PMID 17316622]
  • Homozygous deletion of CDKN2B and CDKN2A detected in head and neck squamous cell carcinoma cell lines. [PMID 16618910]
  • Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) [PMID 20738937]
  • Genome-wide association study of gene-disease association. (HuGE Navigator) [PMID 18489844]
  • CDKN2B is significantly associated with open-angle glaucoma. [PMID 21427129]
  • CDKN2B (p15(INK4b)), CDKN2A (p16(INK4a), p14(ARF)), and MTAP are abundantly expressed in atherosclerotic lesions. [PMID 20637465]
  • Promoter sequence of the p15 CDKN2B gene differ among normal Japanese individuals. Promoter polymorphisms in this gene can influence gene transcription. [PMID 20862607]
  • Observational study of genotype prevalence. (HuGE Navigator) [PMID 20862607]
  • Data show that SNPs in CDKN2B did not confer a significant risk for type 2 diabetes in Pima Indians. [PMID 19008344]
  • Phenylhexyl isothiocyanate treatment results in the demethylation of CPG island in p15 gene, inducing re-expression of p15 in Molt-4 cells. [PMID 20561406]
  • The CDKN2B was methylated in 50%(6/12)of the analyzed samples in pediatric myelodysplastic syndrome(MDS). [PMID 16890288]
  • Activation of ERK together with its downstream transcriptional machinery mediated p15(INK4b) expression that led to HepG2 growth inhibition triggered by TPA and Saikosaponin a. [PMID 12592382]
  • TP53, CDKN1A, CDKN2A, and CDKN2B have roles in tumorigenesis in skin melanomas, but none of them is a main mutation target for melanoma tumorigenesis [PMID 15819981]

PubMed Articles

Recent articles:

  • Huang J et al. “1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data.” Eur J Hum Genet. 2012 Jul;20(7):801-5. PMID 22293688
  • Osman W et al. “A genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucoma.” Hum Mol Genet. 2012 Jun 15;21(12):2836-42. PMID 22419738
  • Takeuchi F et al. “Genome-wide association study of coronary artery disease in the Japanese.” Eur J Hum Genet. 2012 Mar;20(3):333-40. PMID 21971053
  • Murabito JM et al. “Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies.” Circ Cardiovasc Genet. 2012 Feb 1;5(1):100-12. PMID 22199011
  • Congrains A et al. “Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B.” Atherosclerosis. 2012 Feb;220(2):449-55. PMID 22178423
  • Cechova H et al. “Monitoring of methylation changes in 9p21 region in patients with myelodysplastic syndromes and acute myeloid leukemia.” Neoplasma. 2012;59(2):168-74. PMID 22248274
  • O’Donnell CJ et al. “Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction.” Circulation. 2011 Dec 20;124(25):2855-64. PMID 22144573
  • Iacobucci I et al. “CDKN2A/B alterations impair prognosis in adult BCR-ABL1-positive acute lymphoblastic leukemia patients.” Clin Cancer Res. 2011 Dec 1;17(23):7413-23. PMID 22134481
  • Wang Y et al. “Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a Chinese population.” PLoS One. 2011;6(11):e26953. PMID 22096510
  • Wang SS et al. “Joint associations between genetic variants and reproductive factors in glioma risk among women.” Am J Epidemiol. 2011 Oct 15;174(8):901-8. PMID 21920947

Top Pubmed articles linked to gene CDKN2B matching any search term:

  • Iwata M et al. “Genetic risk score constructed using 14 susceptibility alleles for type 2 diabetes is associated with the early onset of diabetes and may predict the future requirement of insulin injections among Japanese individuals.” Diabetes Care. 2012 Aug;35(8):1763-70. PMID 22688542
  • Huang J et al. “1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data.” Eur J Hum Genet. 2012 Jul;20(7):801-5. PMID 22293688
  • Hotta K et al. “Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography.” J Hum Genet. 2012 May;57(5):305-10. PMID 22377712
  • Yang J et al. “Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits.” Nat Genet. 2012 Mar 18;44(4):369-75, S1-3. PMID 22426310
  • Bao XY et al. “Association between type 2 diabetes and CDKN2A/B: a meta-analysis study.” Mol Biol Rep. 2012 Feb;39(2):1609-16. PMID 21625859
  • Nemr R et al. “Replication study of common variants in CDKAL1 and CDKN2A/2B genes associated with type 2 diabetes in Lebanese Arab population.” Diabetes Res Clin Pract. 2012 Feb;95(2):e37-40. PMID 22119613
  • Saade S et al. “Large scale association analysis identifies three susceptibility loci for coronary artery disease.” PLoS One. 2011;6(12):e29427. PMID 22216278
  • Wang Y et al. “Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a Chinese population.” PLoS One. 2011;6(11):e26953. PMID 22096510
  • Sousa AG et al. “Association between genetics of diabetes, coronary artery disease, and macrovascular complications: exploring a common ground hypothesis.” Rev Diabet Stud. 2011 Summer;8(2):230-44. PMID 22189546
  • Shea J et al. “Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction.” Nat Genet. 2011 Jul 24;43(8):801-5. PMID 21775993
  • de Miguel-Yanes JM et al. “Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.” Diabetes Care. 2011 Jan;34(1):121-5. PMID 20889853
  • Pechlivanis S et al. “Coronary artery calcification and its relationship to validated genetic variants for diabetes mellitus assessed in the Heinz Nixdorf recall cohort.” Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1867-72. PMID 20616309
  • Voight BF et al. “Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.” Nat Genet. 2010 Jul;42(7):579-89. PMID 20581827
  • Lin Y et al. “Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population.” BMC Med Genet. 2010 Jun 15;11:97. PMID 20550665
  • Talmud PJ et al. “Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study.” BMJ. 2010 Jan 14;340:b4838. PMID 20075150
  • Tan JT et al. “Polymorphisms identified through genome-wide association studies and their associations with type 2 diabetes in Chinese, Malays, and Asian-Indians in Singapore.” J Clin Endocrinol Metab. 2010 Jan;95(1):390-7. PMID 19892838
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