CRHBP

General Information

Full gene name:corticotropin releasing hormone binding protein Entrez Gene ID:1393 Location:5q11.2-q13.3 Synonyms:CRFBP, CRF-BP Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs4457053	159650	downstream

NCBI Summary

Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]

OMIM

OMIM ID:`OMIM ID 122559 `_

NCBI Phenotypes

No phenotypes found linked to this gene.

Gene Ontology

• Golgi apparatus
• regulation of behavior
• dendrite
• cellular response to tumor necrosis factor
• multivesicular body
• regulation of corticotropin secretion
• negative regulation of corticotropin secretion
• negative regulation of corticotropin-releasing hormone receptor activity
• extracellular space
• perikaryon
• maternal aggressive behavior
• microtubule
• protein binding
• intracellular
• endoplasmic reticulum
• regulation of N-methyl-D-aspartate selective glutamate receptor activity
• regulated secretory pathway
• secretory granule
• hormone metabolic process
• behavioral response to ethanol
• cellular response to stress
• secondary lysosome
• peptide binding
• cellular response to estradiol stimulus
• dense core granule
• hormone-mediated signaling pathway
• synaptic transmission, dopaminergic
• cellular response to potassium ion
• cellular response to cocaine
• nucleus
• corticotropin-releasing hormone binding
• cellular response to cAMP
• learning or memory
• varicosity
• cellular response to gonadotropin-releasing hormone
• cellular response to drug
• signal transduction
• axon terminus
• female pregnancy
• behavior
• inflammatory response
• cellular response to calcium ion
• cellular response to estrogen stimulus

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

• interaction of CRHR1 SNP rs110402 and SNP rs3811939 predicts high risk of comorbid alcoholism in schizophrenic patients [PMID 21810631]
• Reconstituted Complex [PMID 8612563]
• expression of CRH-BP, CRH-R1 and CRH-R2 in uterine tissues is down-regulated during pregnancy; the most pronounced down-regulation of CRH-BP and CRH-R2 occurred in laboring cervix, irrespective the length of gestation [PMID 16734917]
• CRF-BP has distinct and separable binding surfaces for CRF and Ucn 1 [PMID 18234674]
• analysis of regulation and function of CRH-BP [review] [PMID 16368564]
• Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) [PMID 20368512]
• SNP rs10473984 affects response to citalopram in African American and Hispanic patients with major depressive disorder [PMID 20368512]
• Detected in myometrium. Widespread expression of CRH system in gestational tissue suggests paracrine role CRH in birth process (e.g. effects on macrophages and endothelial cells). [PMID 12784189]
• CRH-BP modulates CRH which influences cortical and hippocampal EEG activity and is the primary mediator of the neuroendocrine stress response. this suggest a likely role for CRH-BP in stress-related alcoholism. [PMID 18974851]
• genotype analyses yielded significant association between CRHBP and suicide attempt (P = 0.035); interaction analysis showed significant interaction between CRH receptor type 1 and CRHBP in influencing suicide attempt and severity of suicidal behaviour [PMID 18838498]
• An isolated Swedish population does not support a role for the CRF-BP gene in the vulnerability for bipolar disorder. [PMID 17728670]
• Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) [PMID 18818748]
• Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) [PMID 20379614]
• The corticotropin releasing hormone binding protein gene is likely to be involved in the genetic vulnerability for major depression. [PMID 14573312]
• In white women, non-smokers with the CT genotype at CRH-BP + 17487 have lower Nugent scores than non-smokers with the TT genotype; whereas smokers with the CT genotype have higher Nugent scores than smokers with the TT genotype [PMID 19131402]
• Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) [PMID 19131402]
• Five single nucleotide polymorphisms (SNPs) and a deletion polymorphism in the CRF-BP gene were genotyped and the haplotype block structure of the gene was assessed. [PMID 17599466]
• We found a significant decrease in CRF-BP mRNA levels in the basolateral amygdala of male bipolar and male schizophrenic subjects and the lateral amygdala of male bipolar subjects compared to controls. [PMID 16482088]
• CRHBP variation may predispose, independently and additively, to suicidal behavior in individuals who have experienced childhood trauma. [PMID 21978546]
• The placenta was identified as the main site of the CRH-BP mRNA expression during the last weeks of pregnancy [PMID 15072543]
• results extend recent preclinical and clinical findings implicating the CRH-BP in stress-related alcoholism and confirm the role of the Asp40 allele of the OPRM1 gene in reward-driven alcohol phenotypes [PMID 21039637]
• Observational study of gene-disease association. (HuGE Navigator) [PMID 21039637]

PubMed Articles

Recent articles:

• Roy A et al. “Two HPA axis genes, CRHBP and FKBP5, interact with childhood trauma to increase the risk for suicidal behavior.” J Psychiatr Res. 2012 Jan;46(1):72-9. PMID 21978546
• Ribbe K et al. “Prediction of the risk of comorbid alcoholism in schizophrenia by interaction of common genetic variants in the corticotropin-releasing factor system.” Arch Gen Psychiatry. 2011 Dec;68(12):1247-56. PMID 21810631
• Bosker FJ et al. “Poor replication of candidate genes for major depressive disorder using genome-wide association data.” Mol Psychiatry. 2011 May;16(5):516-32. PMID 20351714
• Ray LA et al. “Stress-induced and cue-induced craving for alcohol in heavy drinkers: Preliminary evidence of genetic moderation by the OPRM1 and CRH-BP genes.” Alcohol Clin Exp Res. 2011 Jan;35(1):166-74. PMID 21039637
• Holliday KL et al. “Genetic variation in neuroendocrine genes associates with somatic symptoms in the general population: results from the EPIFUND study.” J Psychosom Res. 2010 May;68(5):469-74. PMID 20403506
• Binder EB et al. “Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment response.” Arch Gen Psychiatry. 2010 Apr;67(4):369-79. PMID 20368512
• Rose JE et al. “Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.” Mol Med. 2010 Jul-Aug;16(7-8):247-53. PMID 20379614
• Holliday KL et al. “Genetic variation in the hypothalamic-pituitary-adrenal stress axis influences susceptibility to musculoskeletal pain: results from the EPIFUND study.” Ann Rheum Dis. 2010 Mar;69(3):556-60. PMID 19723618
• Ryckman KK et al. “Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.” PLoS One. 2010 Feb 3;5(2):e9040. PMID 20140262
• Tabakoff B et al. “Genetical genomic determinants of alcohol consumption in rats and humans.” BMC Biol. 2009 Oct 27;7:70. PMID 19874574

Top Pubmed articles linked to gene CRHBP matching any search term:

• Muráni E et al. “Association of HPA axis-related genetic variation with stress reactivity and aggressive behaviour in pigs.” BMC Genet. 2010 Aug 9;11:74. PMID 20696048
• Myatt L et al. “Prediction of preeclampsia.” Semin Perinatol. 1999 Feb;23(1):45-57. PMID 10102170
• Perkins AV et al. “Plasma measurements of corticotrophin-releasing hormone-binding protein in normal and abnormal human pregnancy.” J Endocrinol. 1993 Jul;138(1):149-57. PMID 7852886