EXOC6

General Information

Full gene name:exocyst complex component 6 Entrez Gene ID:54536 Location:10q23.33 Synonyms:EXOC6A, SEC15L, SEC15, Sec15p, SEC15L3, SEC15L1 Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs1111875	131588	upstream

NCBI Summary

The product of this gene belongs to the SEC15 family. It is highly similar to the protein encoded by Saccharomyces cerevisiae SEC15 gene. This protein is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

OMIM

OMIM ID:`OMIM ID 609672 `_

NCBI Phenotypes

No phenotypes found linked to this gene.

Gene Ontology

• vesicle docking involved in exocytosis
• exocyst
• plasma membrane
• erythrocyte differentiation
• protein transport

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

• Sec15 has a role as an effector for the Rab11 GTPase in mammalian cells [PMID 15292201]
• The SEC15 protein plays a crucial role in integrating the signals between Sec4p and the components of the early-polarity-establishment machinery. [PMID 16478783]
• Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) [PMID 20379614]
• Observational study of gene-disease association. (HuGE Navigator) [PMID 21044367]
• Affinity Capture-Western [PMID 22172676]
• Affinity Capture-MS [PMID 21906983]
• coordinated disruption of the Rab11/Sec15 exocyst by anthrax toxins may contribute to toxin-dependent barrier disruption and vascular dysfunction during B. anthracis infection [PMID 20944747]

PubMed Articles

Recent articles:

• Jin Y et al. “Myosin V transports secretory vesicles via a Rab GTPase cascade and interaction with the exocyst complex.” Dev Cell. 2011 Dec 13;21(6):1156-70. PMID 22172676
• Kim W et al. “Systematic and quantitative assessment of the ubiquitin-modified proteome.” Mol Cell. 2011 Oct 21;44(2):325-40. PMID 21906983
• Wagner SA et al. “A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.” Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. PMID 21890473
• Danielsen JM et al. “Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.” Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. PMID 21139048
• Tatonetti NP et al. “An integrative method for scoring candidate genes from association studies: application to warfarin dosing.” BMC Bioinformatics. 2010 Oct 28;11 Suppl 9:S9. PMID 21044367
• Guichard A et al. “Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst.” Nature. 2010 Oct 14;467(7317):854-8. PMID 20944747
• Rose JE et al. “Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.” Mol Med. 2010 Jul-Aug;16(7-8):247-53. PMID 20379614
• France YE et al. “The polarity-establishment component Bem1p interacts with the exocyst complex through the Sec15p subunit.” J Cell Sci. 2006 Mar 1;119(Pt 5):876-88. PMID 16478783
• Grupe A et al. “A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.” Am J Hum Genet. 2006 Jan;78(1):78-88. PMID 16385451
• Kimura K et al. “Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.” Genome Res. 2006 Jan;16(1):55-65. PMID 16344560