KCNQ1DN

General Information

Full gene name:KCNQ1 downstream neighbor (non-protein coding) Entrez Gene ID:55539 Location:11p15.4 Synonyms:BWRT, HSA404617 Type:miscRNA

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs2237892	51512	upstream
rs231362	199792	upstream

NCBI Summary

Imprinting is a phenomenon in which epigenetic modifications lead to expression or suppression of alleles of some genes based on their parental origin. Wilms tumor-2 (WT2; MIM 194071) is defined by maternal-specific loss of heterozygosity of a critical region on chromosome 11p15.5 that includes several imprinted genes. KCNQ1DN is an imprinted gene located within the WT2 critical region that is expressed from the maternal allele (Xin et al., 2000 [PubMed 11056398]).[supplied by OMIM, Mar 2008]

OMIM

OMIM ID:`OMIM ID 610980 `_

NCBI Phenotypes

No phenotypes found linked to this gene.

Gene Ontology

• molecular_function
• cellular_component
• biological_process

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

None available.

PubMed Articles

Recent articles:

• Koch CM et al. “Epigenetic-aging-signature to determine age in different tissues.” Aging (Albany NY). 2011 Oct;3(10):1018-27. PMID 22067257
• Gerhard DS et al. “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” Genome Res. 2004 Oct;14(10B):2121-7. PMID 15489334
• Strausberg RL et al. “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.” Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. PMID 12477932
• Xin Z et al. “A novel imprinted gene, KCNQ1DN, within the WT2 critical region of human chromosome 11p15.5 and its reduced expression in Wilms’ tumors.” J Biochem. 2000 Nov;128(5):847-53. PMID 11056398
• Engemann S et al. “Sequence and functional comparison in the Beckwith-Wiedemann region: implications for a novel imprinting centre and extended imprinting.” Hum Mol Genet. 2000 Nov 1;9(18):2691-706. PMID 11063728