MIR29A

General Information

Full gene name:microRNA 29a Entrez Gene ID:407021 Location:7q32.3 Synonyms:hsa-mir-29, miRNA29A, hsa-mir-29a, MIRN29A, MIRN29 Type:miscRNA

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs972283	94652	downstream

NCBI Summary

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

OMIM

OMIM ID:`OMIM ID 610782 `_

NCBI Phenotypes

No phenotypes found linked to this gene.

Gene Ontology

No GO terms found linked to this gene.

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

• Data showed that miR-29a negatively regulated collagen IV by directly targeting the 3’UTRs of col4a1 and col4a2. [PMID 20067797]
• miR-29 is epigenetically silenced by an activated NF-kappaB-YY1 pathway and is associated with rhabdomyosarcoma. [PMID 18977326]
• There is a significant impact of miR-29a on the risk of recurrence in patients with stage II but not in patients with stage I colon cancer. [PMID 22426940]
• Our data indicate that miR-29a regulates early hematopoiesis and suggest that miR-29a initiates acute myeloid leukemia by converting myeloid progenitors into self-renewing leukemia stem cells [PMID 20212066]
• Observational study of gene-disease association. (HuGE Navigator) [PMID 20889907]
• miR-29 inhibits CDK6 protein & mRNA levels by direct binding to 3’-untranslated region. Down-regulation of miR-29 could cooperate with cyclin D1 in mantle-cell lymphoma pathogenesis. [PMID 20086245]
• miR-29 acts as a regulator of cardiac fibrosis and represents a potential therapeutic target for tissue fibrosis in general. [PMID 18723672]
• Cellular miRNA hsa-miR29a downregulates the expression of Nef protein and interferes with HIV-1 replication. [PMID 19102781]
• Data demonstrate that miR-29 and Wnt signaling are involved in a regulatory circuit that can modulate osteoblast differentiation. [PMID 20551325]
• Data showed miR-29a expression was 4.5-fold higher in indolent CLL than in normal CD19+ B cells, whereas aggressive CLL samples showed a 3.2-fold increase. [PMID 20566844]
• miR-29a/c could be potential biomarkers for colorectal cancer early recurrence. [PMID 22348113]
• MIRN29A(microRNA 29a) is one of the human microRNAs which target the nef trsnacript in HIV-1 as evidenced by computational predictions. [PMID 16236258]
• Loss of specific miRNAs can contribute to increased BACE1 and Abeta levels in sporadic Alzheimer’s disease. [PMID 18434550]
• miR-29a, miR-29b selectively target MCT1 3’UTR ; the miR-29 isoforms are highly expressed in islets and contribute to silencing Mct1 in beta cells; miR-29 isoforms contribute to beta-cell-specific silencing of the MCT1 transporter and may affect insuli... [PMID 21646425]
• an increase of miR-29a, and hence decrease of Nasp, may contribute to inhibit cell proliferation during postnatal organ development. [PMID 22194605]
• Data show that t(6;7)(p25.3;q32.3) was associated with down-regulation of DUSP22 and up-regulation of MIR29 microRNAs on 7q32.3. [PMID 21030553]
• down regulation of miR-34a, miR-29 and miR-17-5p in aggressive CLL with TP53 abnormalities [PMID 19347736]
• A significant inverse relationship between miR-29a and total MMP-2 was identified in the thoracic aortic aneurysm specimens. [PMID 22010139]
• Synthetic miR-29a represents a potential new tool to affect tumorigenesis in these lymphomas. [PMID 21471522]
• methylation-dependent tissue-specific regulation of the lncRNA MEG3 by miR-29a may contribute to hepatocellular cancer growth. [PMID 21625215]
• miR-29 and miR-30 regulate B-Myb expression by binding to its 3’UTR; these microRNAs play an important role in Rb-driven cellular senescence [PMID 21187425]
• the regulatory relationship between miRNAs and the p42.3 gene [PMID 21998710]
• Results indicate that in addition to c-Myc, mir-29b-1/mir-29a expression can be suppressed by hedgehog signaling and inflammatory pathways, both commonly activated in the genesis of malignancies. [PMID 20564213]
• MiR29 suppresses DNMT activity and thus induces expression of COX2 and PGE2 during influenza A virus infection. [PMID 22072783]
• miR-29 antagonism may promote increased elastin levels during conditions of elastin deficiencies. [PMID 22095981]
• The findings derived from this study identify the miR-29 family as a critical regulator of ECM expression in the TM and suggest that its modulation by TGF-beta2 may be important in controlling ECM synthesis. [PMID 21330653]
• miR-29a and miR-142-3p are downregulated in acute myeloid leukemia and have potential value as molecular diagnostic markers. [PMID 21678057]
• Findings suggest that serum miR-29a has strong potential as a novel noninvasive biomarker for early detection of CRC with liver metastasis. [PMID 22018950]

PubMed Articles

Recent articles:

• Weissmann-Brenner A et al. “Tumor microRNA-29a expression and the risk of recurrence in stage II colon cancer.” Int J Oncol. 2012 Jun;40(6):2097-103. PMID 22426940
• Ma W et al. “MicroRNA-29a inhibited epididymal epithelial cell proliferation by targeting nuclear autoantigenic sperm protein (NASP).” J Biol Chem. 2012 Mar 23;287(13):10189-99. PMID 22194605
• Zhang P et al. “Inhibition of microRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels–brief report.” Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):756-9. PMID 22095981
• Wang F et al. “miR-29a and miR-142-3p downregulation and diagnostic implication in human acute myeloid leukemia.” Mol Biol Rep. 2012 Mar;39(3):2713-22. PMID 21678057
• Kuo TY et al. “Computational analysis of mRNA expression profiles identifies microRNA-29a/c as predictor of colorectal cancer early recurrence.” PLoS One. 2012;7(2):e31587. PMID 22348113
• Wang LG et al. “Serum microRNA-29a is a promising novel marker for early detection of colorectal liver metastasis.” Cancer Epidemiol. 2012 Feb;36(1):e61-7. PMID 22018950
• Fang J et al. “Epigenetic changes mediated by microRNA miR29 activate cyclooxygenase 2 and lambda-1 interferon production during viral infection.” J Virol. 2012 Jan;86(2):1010-20. PMID 22072783
• Jones JA et al. “Selective microRNA suppression in human thoracic aneurysms: relationship of miR-29a to aortic size and proteolytic induction.” Circ Cardiovasc Genet. 2011 Dec;4(6):605-13. PMID 22010139
• Cui Y et al. “MiR-29a inhibits cell proliferation and induces cell cycle arrest through the downregulation of p42.3 in human gastric cancer.” PLoS One. 2011;6(10):e25872. PMID 21998710
• Pullen TJ et al. “miR-29a and miR-29b contribute to pancreatic beta-cell-specific silencing of monocarboxylate transporter 1 (Mct1).” Mol Cell Biol. 2011 Aug;31(15):3182-94. PMID 21646425

Top Pubmed articles linked to gene MIR29A matching any search term:

• Pullen TJ et al. “miR-29a and miR-29b contribute to pancreatic beta-cell-specific silencing of monocarboxylate transporter 1 (Mct1).” Mol Cell Biol. 2011 Aug;31(15):3182-94. PMID 21646425
• Du B et al. “High glucose down-regulates miR-29a to increase collagen IV production in HK-2 cells.” FEBS Lett. 2010 Feb 19;584(4):811-6. PMID 20067797