MIR29B1

General Information

Full gene name:microRNA 29b-1 Entrez Gene ID:407024 Location:7q32.3 Synonyms:MIRN29B1, miRNA29B1 Type:miscRNA

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs972283	95364	downstream

NCBI Summary

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

OMIM

OMIM ID:`OMIM ID 610783 `_

NCBI Phenotypes

No phenotypes found linked to this gene.

Gene Ontology

No GO terms found linked to this gene.

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

• Results indicate that in addition to c-Myc, mir-29b-1/mir-29a expression can be suppressed by hedgehog signaling and inflammatory pathways, both commonly activated in the genesis of malignancies. [PMID 20564213]
• Loss of specific miRNAs can contribute to increased BACE1 and Abeta levels in sporadic Alzheimer’s disease. [PMID 18434550]
• MiR-29b negatively regulates the expression of multiple genes involved in the synthesis and deposition of extracellular matrix in trabecular meshwork (TM) cells. [PMID 19956414]
• Observational study of gene-disease association. (HuGE Navigator) [PMID 19048628]
• MIR-29b deregulation contributes to angiogenesis, invasion, and metastasis of hepatocellular carcinoma. [PMID 21793034]
• Data showed that miR-29b expression was increased 4-fold in indolent CLL and 3.5-fold in aggressive CLL. [PMID 20566844]
• CEBPA selectively regulates miR-29b expression on its miR-29a/b1 locus on chromosome 7q32.3. [PMID 20628397]
• These findings identify miR-29b as a novel posttranscriptional regulator of PGRN expression, raising the possibility that miR-29b or other miRNAs might be targeted therapeutically to increase hPGRN levels in some frontotemporal dementia patients. [PMID 20479936]
• The ability of LMP1 to negatively regulate TCL1 through miR-29b might underlie its B-cell lymphoma growth antagonistic property. [PMID 19966860]
• Histone deacetylases mediate the silencing of miR-15a, miR-16, and miR-29b in chronic lymphocytic leukemia. [PMID 22096249]
• Down-regulation of DNMT3A & DNMT3B results from direct interaction of miR-29b with the 3’ untranslated regions of these genes. miR-29b down-regulates DNMT1 indirectly by targeting Sp1. [PMID 19211935]
• These findings suggest that miRNA-29b may play an important role in MM as a tumor suppressor. [PMID 21951844]
• Aberrant expression of miR-29b, which modulates PTEN expression, can contribute to migration, invasion, and anti-apoptosis [PMID 21359530]
• miR-29b predominantly localized to the nucleus; the hexanucleotide terminal motif of miR-29b acts as a transferable nuclear localization element that directs nuclear enrichment of miRNAs or small interfering RNAs to which it is attached [PMID 17204650]

PubMed Articles

Recent articles:

• Sampath D et al. “Histone deacetylases mediate the silencing of miR-15a, miR-16, and miR-29b in chronic lymphocytic leukemia.” Blood. 2012 Feb 2;119(5):1162-72. PMID 22096249
• Fang JH et al. “MicroRNA-29b suppresses tumor angiogenesis, invasion, and metastasis by regulating matrix metalloproteinase 2 expression.” Hepatology. 2011 Nov;54(5):1729-40. PMID 21793034
• Zhang YK et al. “Overexpression of microRNA-29b induces apoptosis of multiple myeloma cells through down regulating Mcl-1.” Biochem Biophys Res Commun. 2011 Oct 14;414(1):233-9. PMID 21951844
• Wang C et al. “miR-29b regulates migration of human breast cancer cells.” Mol Cell Biochem. 2011 Jun;352(1-2):197-207. PMID 21359530
• Mott JL et al. “Transcriptional suppression of mir-29b-1/mir-29a promoter by c-Myc, hedgehog, and NF-kappaB.” J Cell Biochem. 2010 Aug 1;110(5):1155-64. PMID 20564213
• Eyholzer M et al. “The tumour-suppressive miR-29a/b1 cluster is regulated by CEBPA and blocked in human AML.” Br J Cancer. 2010 Jul 13;103(2):275-84. PMID 20628397
• Santanam U et al. “Chronic lymphocytic leukemia modeled in mouse by targeted miR-29 expression.” Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12210-5. PMID 20566844
• Jiao J et al. “MicroRNA-29b regulates the expression level of human progranulin, a secreted glycoprotein implicated in frontotemporal dementia.” PLoS One. 2010 May 10;5(5):e10551. PMID 20479936
• Anastasiadou E et al. “Epstein-Barr virus encoded LMP1 downregulates TCL1 oncogene through miR-29b.” Oncogene. 2010 Mar 4;29(9):1316-28. PMID 19966860
• Luna C et al. “Role of miR-29b on the regulation of the extracellular matrix in human trabecular meshwork cells under chronic oxidative stress.” Mol Vis. 2009 Nov 28;15:2488-97. PMID 19956414

Top Pubmed articles linked to gene MIR29B1 matching any search term:

• Wang C et al. “miR-29b regulates migration of human breast cancer cells.” Mol Cell Biochem. 2011 Jun;352(1-2):197-207. PMID 21359530