PRC1

General Information

Full gene name:protein regulator of cytokinesis 1 Entrez Gene ID:9055 Location:15q26.1 Synonyms:ASE1 Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs8042680	0	within

NCBI Summary

This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

OMIM

OMIM ID:`OMIM ID 603484 `_

NCBI Phenotypes

• Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
• NHGRI GWA Catalog

Gene Ontology

• nucleolus
• protein kinase binding
• microtubule cytoskeleton
• protein binding
• identical protein binding
• spindle microtubule
• mitotic spindle elongation
• nucleus
• cytoplasm
• spindle
• cytokinesis
• spindle pole
• plasma membrane

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

• The radiosensitizing effect of paclitaxel on KB cells may be due to the down-regulated expression of PRC1 and cyclin B2. [PMID 19664331]
• Microtubule-associated protein (MAP) Prc1 facilitate Plk1 phosphorylation of HsCyk-4. [PMID 19468300]
• Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) [PMID 20889853]
• Affinity Capture-MS [PMID 19471022]
• PRC1 is an essential factor in controlling the spatiotemporal formation of the midzone in human cells. [PMID 16603632]
• transcription is controlled by p53 via regulating cytokinesis [PMID 15531928]
• These results provide a potential mechanistic basis for the defective cytokinesis phenotype exhibited by HSF2-/- cells, as well as suggest a potential role for PRC1 in HSF2-mediated gene bookmarking. [PMID 18570919]
• Data propose that PRC1 forms a link between stabilization of CLASP1 association with central spindle microtubules and anti-parallel microtubule elongation. [PMID 19561070]
• Affinity Capture-MS [PMID 20360068]
• Affinity Capture-MS [PMID 20360068]
• Affinity Capture-MS [PMID 20360068]
• Affinity Capture-MS [PMID 19531213]
• contributes to the correct formation of the spindle during the metaphase [PMID 14744859]
• Dosage Lethality [PMID 22623531]
• PRC1’s microtubule binding is mediated by a structured domain with a spectrin-fold and an unstructured Lys/Arg-rich domain. [PMID 20691902]
• suggest the involvement of a PRC1- kinesin family member 2C/mitotic centromere-associated kinesin complex in breast tumorigenesis, and this complex should be a promising target for the development of novel treatments for breast cancer [PMID 17233835]
• role of PRC1 in midzone formation, indicate that cell cycle-dependent translocation of PRC1 by Kif4 is essential for midzone formation and cytokinesis. [PMID 15625105]
• Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) [PMID 19609347]
• Affinity Capture-MS [PMID 21906983]
• kinesin family member 4 and its binding partner PRC1 play essential roles in the organization of central spindles and midzone formation [PMID 15297875]
• Affinity Capture-Western; Reconstituted Complex; Two-hybrid [PMID 15297875]
• Affinity Capture-Western; Reconstituted Complex [PMID 15297875]
• Affinity Capture-Western; Reconstituted Complex [PMID 15297875]
• Two-hybrid [PMID 16189514]
• Two-hybrid [PMID 16189514]
• Two-hybrid [PMID 16189514]
• Affinity Capture-Western; Two-hybrid [PMID 16189514]
• PRC1 is a microtubule-associated protein required to maintain the spindle midzone, and that distinct functions are associated with modular elements of the primary sequence. [PMID 12082078]
• Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) [PMID 20379614]
• Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) [PMID 20056645]
• PRC1 is a microtubule bundling protein that is critical to the formation of the central spindle, which is required for abscission but not for furrowing in mammalian cells [PMID 15616196]

PubMed Articles

Recent articles:

• Hu CK et al. “Plk1 negatively regulates PRC1 to prevent premature midzone formation before cytokinesis.” Mol Biol Cell. 2012 Jul;23(14):2702-11. PMID 22621898
• Toyoshima M et al. “Functional genomics identifies therapeutic targets for MYC-driven cancer.” Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9545-50. PMID 22623531
• Shrestha S et al. “PRC1 controls spindle polarization and recruitment of cytokinetic factors during monopolar cytokinesis.” Mol Biol Cell. 2012 Apr;23(7):1196-207. PMID 22323288
• Hu CK et al. “Midbody assembly and its regulation during cytokinesis.” Mol Biol Cell. 2012 Mar;23(6):1024-34. PMID 22278743
• Kim W et al. “Systematic and quantitative assessment of the ubiquitin-modified proteome.” Mol Cell. 2011 Oct 21;44(2):325-40. PMID 21906983
• Ugras S et al. “Small RNA sequencing and functional characterization reveals MicroRNA-143 tumor suppressor activity in liposarcoma.” Cancer Res. 2011 Sep 1;71(17):5659-69. PMID 21693658
• Danielsen JM et al. “Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.” Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. PMID 21139048
• de Miguel-Yanes JM et al. “Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.” Diabetes Care. 2011 Jan;34(1):121-5. PMID 20889853
• Pal D et al. “Role of a novel coiled-coil domain-containing protein CCDC69 in regulating central spindle assembly.” Cell Cycle. 2010 Oct 15;9(20):4117-29. PMID 20962590
• Subramanian R et al. “Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein.” Cell. 2010 Aug 6;142(3):433-43. PMID 20691902

Top Pubmed articles linked to gene PRC1 matching any search term:

• Ohshige T et al. “Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese.” PLoS One. 2011;6(10):e26911. PMID 22046406
• Nielsen T et al. “Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release.” Diabetologia. 2011 May;54(5):1052-6. PMID 21267535
• de Miguel-Yanes JM et al. “Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.” Diabetes Care. 2011 Jan;34(1):121-5. PMID 20889853
• Voight BF et al. “Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.” Nat Genet. 2010 Jul;42(7):579-89. PMID 20581827
• Wickner RB et al. “How to find a prion: [URE3], [PSI+] and [beta].” Methods. 2006 May;39(1):3-8. PMID 16793280
• Peng L et al. “Sitosterol-beta-glucoside as primer for cellulose synthesis in plants.” Science. 2002 Jan 4;295(5552):147-50. PMID 11778054
• Read SM et al. “Plant biology. Prime time for cellulose.” Science. 2002 Jan 4;295(5552):59-60. PMID 11778033
• Babb VM et al. “Sucrose phosphate synthase activity rises in correlation with high-rate cellulose synthesis in three heterotrophic systems.” Plant Physiol. 2001 Nov;127(3):1234-42. PMID 11706202
• Brett CT et al. “Cellulose microfibrils in plants: biosynthesis, deposition, and integration into the cell wall.” Int Rev Cytol. 2000;199:161-99. PMID 10874579
• Li AX et al. “An acyltransferase catalyzing the formation of diacylglucose is a serine carboxypeptidase-like protein.” Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6902-7. PMID 10829071
• Carpita N et al. “A recipe for cellulose.” Science. 1998 Jan 30;279(5351):672-3. PMID 9471727
• Vijayan MM et al. “Handling stress does not affect the expression of hepatic heat shock protein 70 and conjugation enzymes in rainbow trout treated with beta-naphthoflavone.” Life Sci. 1997;61(2):117-27. PMID 9217270