STARD10

General Information

Full gene name:StAR-related lipid transfer (START) domain containing 10 Entrez Gene ID:10809 Location:11q13 Synonyms:NY-CO-28, PCTP2, SDCCAG28, CGI-52 Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs1552224	32676	downstream

NCBI Summary

None available.

OMIM

No OMIM data available for this gene.

NCBI Phenotypes

No phenotypes found linked to this gene.

Gene Ontology

No GO terms found linked to this gene.

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

• Observational study of gene-disease association. (HuGE Navigator) [PMID 19913121]
• Stard10 (Sdccag28) is much more highly transcribed in mouse cardiac atria than in cardiac ventricles. [PMID 14576202]
• Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) [PMID 20628086]
• A nonpredicted link between SNAI1-triggered EMT and the down-regulation of Nectin-1 and StarD10 through the up-regulation of miR-661, which may contribute to the invasion of breast cancer cells and poor disease outcome. [PMID 20543867]
• C-terminal StarD10 phosphorylation on serine 284 regulates its association with cellular membranes [PMID 17561512]
• StarD10 interacts with phosphatidylcholine and phosphatidylethanolamine and preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position [PMID 15911624]
• Data show that in multivariate analyses incorporating tumor size, tumor grade, lymph node status, ER, PR and HER2 status, low STARD10 expression was an independent predictor of death from breast cancer. [PMID 19676041]

PubMed Articles

Recent articles:

• Bailey SD et al. “Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.” Diabetes Care. 2010 Oct;33(10):2250-3. PMID 20628086
• Vetter G et al. “miR-661 expression in SNAI1-induced epithelial to mesenchymal transition contributes to breast cancer cell invasion by targeting Nectin-1 and StarD10 messengers.” Oncogene. 2010 Aug 5;29(31):4436-48. PMID 20543867
• Murphy NC et al. “Loss of STARD10 expression identifies a group of poor prognosis breast cancers independent of HER2/Neu and triple negative status.” Int J Cancer. 2010 Mar 15;126(6):1445-53. PMID 19676041
• Talmud PJ et al. “Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.” Am J Hum Genet. 2009 Nov;85(5):628-42. PMID 19913121
• Olayioye MA et al. “Phosphorylation of StarD10 on serine 284 by casein kinase II modulates its lipid transfer activity.” J Biol Chem. 2007 Aug 3;282(31):22492-8. PMID 17561512
• Lamesch P et al. “hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.” Genomics. 2007 Mar;89(3):307-15. PMID 17207965
• Olayioye MA et al. “StarD10, a START domain protein overexpressed in breast cancer, functions as a phospholipid transfer protein.” J Biol Chem. 2005 Jul 22;280(29):27436-42. PMID 15911624
• Gerhard DS et al. “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” Genome Res. 2004 Oct;14(10B):2121-7. PMID 15489334
• Ota T et al. “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Nat Genet. 2004 Jan;36(1):40-5. PMID 14702039
• Tabibiazar R et al. “Transcriptional profiling of the heart reveals chamber-specific gene expression patterns.” Circ Res. 2003 Dec 12;93(12):1193-201. PMID 14576202

Top Pubmed articles linked to gene STARD10 matching any search term:

• Bailey SD et al. “Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.” Diabetes Care. 2010 Oct;33(10):2250-3. PMID 20628086