TP53INP1

General Information

Full gene name:tumor protein p53 inducible nuclear protein 1 Entrez Gene ID:94241 Location:8q22 Synonyms:TP53DINP1, SIP, p53DINP1, Teap, TP53INP1A, TP53INP1B Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs896854	0	within

NCBI Summary

None available.

OMIM

OMIM ID:`OMIM ID 606185 `_

NCBI Phenotypes

• Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
• NHGRI GWA Catalog

Gene Ontology

• PML body
• cell cycle arrest
• induction of apoptosis
• cytosol
• protein binding
• positive regulation of autophagy
• apoptotic process
• autophagy
• positive regulation of transcription, DNA-dependent
• response to stress
• nucleus
• transcription, DNA-dependent
• autophagic cell death
• autophagic vacuole
• cytoplasmic vesicle
• antioxidant activity
• negative regulation of cell proliferation
• negative regulation of cell migration

KEGG Pathways

• HTLV-I infection

GeneRIFs

• Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) [PMID 20889853]
• findings implicate a miR-93/miR-130b-TP53INP1 axis that affects the proliferation and survival of HTLV-1-infected/transformed cells [PMID 18974142]
• TP531NP1 plays a significant role in the progression of anaplastic carcinoma or contributes to anaplastic transformation from papillary or follicular carcinoma, which is in sharp contrast to findings in previous in vitro and in vivo studies. [PMID 17393983]
• E2F4 interacts with the TP53INP1 promoter. [PMID 15706352]
• E2F3 interacts with the TP53INP1 promoter. [PMID 15706352]
• E2F2 interacts with the TP53INP1 promoter. [PMID 15706352]
• E2F1 interacts with the TP53INP1 promoter. [PMID 15706352]
• Assignment of tumor protein p53 induced nuclear protein 1 (TP53INP1) gene to human chromosome band 8q22 by in situ hybridization. [PMID 12438758]
• TP53INP1 identified two conserved regions in the DOR family that concentrate multiple functions crucial for autophagy and transcription. [PMID 22470510]
• The p53DINP1 mRna expression in the antral mucosa was significantly lower in the gastric cancer patients than in the chronic gastritis patients. [PMID 18277906]
• This novel TP53INP1 activity on the regulation of SPARC expression could explain in part its tumor suppressor function in pancreatic adenocarcinoma by modulating cellular spreading during the metastatic process [PMID 21339733]
• TP53INP1 protein negativity is significantly associated with aggressive pathological phenotypes of gastric cancer. [PMID 16521180]
• TP53INP1s and HIPK2 could be partners in regulating p53 activity. [PMID 12851404]
• Affinity Capture-Western; Reconstituted Complex [PMID 12851404]
• Affinity Capture-Western; Reconstituted Complex [PMID 12851404]
• Data show that induction of the stress-induced proteins (SIPs) SIP18 and SIP27, in human- and mouse-derived cell lines, is absent from cells with deleted, mutated or inactive p53, suggesting that regulation of SIP gene expression is dependent on p53. [PMID 12067065]
• PLZF upregulates apoptosis-inducer TP53INP1, ID1, and ID3 genes, and downregulates the apoptosis-inhibitor TERT gene [PMID 17537403]
• TP53INP1s are functionally associated with p73 to regulate cell cycle progression and apoptosis. [PMID 16044147]
• In normal prostate tissues, TP53INP1 is only expressed in prostate basal cells. There is a de novo TP53INP1 expression in prostate luminal cells in inflammatory prostate tissues, high grade PIN lesions and in prostate cancer. [PMID 21538421]
• TP53INP1 is a tumor suppressor in esophageal squamous cell carcinoma (ESCC0; c-Myc-mediated DNA methylation-associated silencing of TP53INP1 contributed to the pathogenesis of human ESCC. [PMID 21219856]
• P53DINP1 mRNA expression promotes Ser46 phophlrylation of p53, without finding a significant correlation between mRNA expression of p53AIP1. [PMID 18277909]

PubMed Articles

Recent articles:

• Sancho A et al. “DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription.” PLoS One. 2012;7(3):e34034. PMID 22470510
• Giusiano S et al. “TP53INP1 overexpression in prostate cancer correlates with poor prognostic factors and is predictive of biological cancer relapse.” Prostate. 2012 Feb 1;72(2):117-28. PMID 21538421
• Seux M et al. “TP53INP1 decreases pancreatic cancer cell migration by regulating SPARC expression.” Oncogene. 2011 Jul 7;30(27):3049-61. PMID 21339733
• Weng W et al. “c-Myc inhibits TP53INP1 expression via promoter methylation in esophageal carcinoma.” Biochem Biophys Res Commun. 2011 Feb 11;405(2):278-84. PMID 21219856
• de Miguel-Yanes JM et al. “Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.” Diabetes Care. 2011 Jan;34(1):121-5. PMID 20889853
• Voight BF et al. “Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.” Nat Genet. 2010 Jul;42(7):579-89. PMID 20581827
• Yeung ML et al. “Roles for microRNAs, miR-93 and miR-130b, and tumor protein 53-induced nuclear protein 1 tumor suppressor in cell growth dysregulation by human T-cell lymphotrophic virus 1.” Cancer Res. 2008 Nov 1;68(21):8976-85. PMID 18974142
• Sawaya M et al. “Difference of p53AIP1 mRNA expression in gastric mucosa between patients with gastric cancer and chronic gastritis infected with Helicobacter pylori.” J Clin Gastroenterol. 2008 Apr;42(4):351-5. PMID 18277906
• Daniele B et al. “Insights in gastric carcinogenesis from Helicobacter pylori infection.” J Clin Gastroenterol. 2008 Apr;42(4):336-7. PMID 18277909
• Bernardo MV et al. “Identification of apoptosis-related PLZF target genes.” Biochem Biophys Res Commun. 2007 Jul 27;359(2):317-22. PMID 17537403

Top Pubmed articles linked to gene TP53INP1 matching any search term:

• Cauchi S et al. “European genetic variants associated with type 2 diabetes in North African Arabs.” Diabetes Metab. 2012 Mar 29;. PMID 22463974
• Zhou Y et al. “Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway.” Hum Mol Genet. 2012 Jan 1;21(1):196-207. PMID 21965303
• Ohshige T et al. “Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese.” PLoS One. 2011;6(10):e26911. PMID 22046406
• Nielsen T et al. “Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release.” Diabetologia. 2011 May;54(5):1052-6. PMID 21267535
• de Miguel-Yanes JM et al. “Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.” Diabetes Care. 2011 Jan;34(1):121-5. PMID 20889853
• Voight BF et al. “Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.” Nat Genet. 2010 Jul;42(7):579-89. PMID 20581827
• Vanlandingham JW et al. “Expression profiling of p53-target genes in copper-mediated neuronal apoptosis.” Neuromolecular Med. 2005;7(4):311-24. PMID 16391388