TRA2B

General Information

Full gene name:transformer 2 beta homolog (Drosophila) Entrez Gene ID:6434 Location:3q26.2-q27 Synonyms:TRA2-BETA, TRAN2B, Htra2-beta, SRFS10, SFRS10 Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs1470579	103278	downstream

NCBI Summary

This gene encodes a nuclear protein which functions as sequence-specific serine/arginine splicing factor which plays a role in mRNA processing, splicing patterns, and gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

OMIM

OMIM ID:`OMIM ID 602719 `_

NCBI Phenotypes

• Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
• Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
• NHGRI GWA Catalog

Gene Ontology

• regulation of alternative nuclear mRNA splicing, via spliceosome
• protein binding
• nuclear mRNA splicing, via spliceosome
• nucleus
• RNA splicing, via transesterification reactions
• mRNA binding
• nucleotide binding
• positive regulation of nuclear mRNA splicing, via spliceosome

KEGG Pathways

• Spliceosome

GeneRIFs

• Affinity Capture-MS [PMID 17332742]
• Affinity Capture-MS [PMID 15324660]
• Reconstituted Complex; Two-hybrid [PMID 9671816]
• Affinity Capture-MS [PMID 19759913]
• Affinity Capture-MS [PMID 19471022]
• nuclear hnRNP G level as well as hTra2-beta1 level were independent prognostic factors for endometrial cancer progression-free survival [PMID 20607830]
• reduced expression of SFRS10, as observed in tissues from obese humans, alters LPIN1 splicing, induces lipogenesis, and therefore contributes to metabolic phenotypes associated with obesity. [PMID 21803291]
• RNPS1 interacts with hTra2-beta. [PMID 14729963]
• DARPP-32 changes the usage of tra2-beta1 dependent alternative exons in a concentration-dependent manner, suggesting that the DARPP-32:tra2-beta1 interaction is a molecular link between signaling pathways and pre-mRNA processing. [PMID 20074680]
• Protein-RNA [PMID 11448987]
• Reconstituted Complex [PMID 11875052]
• Affinity Capture-MS [PMID 17353931]
• Affinity Capture-MS [PMID 17353931]
• Affinity Capture-MS [PMID 20360068]
• results implicate the human tau gene as a target gene for the alternative splicing regulator Tra2 beta protein, suggesting that Tra2 beta may play a role in aberrant tau exon 10 alternative splicing [PMID 12649279]
• Tra2beta1 transcript levels are developmentally regulated in a tissue- and temporal-specific pattern, although expression is ubiquitous. [PMID 12798777]
• Affinity Capture-MS [PMID 20508642]
• Affinity Capture-RNA [PMID 21151833]
• Reduced SMN protein levels cause a reduction in the amount of its interacting proteins and of Htra2-beta1 in both discordant and non-discordant spinal muscular atrophy phenotypes. [PMID 14520560]
• Results indicates that the Human Transformer2-beta RNA recognition motif recognizes two types of RNA sequences in different RNA binding modes. [PMID 20926394]
• Affinity Capture-MS [PMID 21906983]
• Affinity Capture-Western; Reconstituted Complex [PMID 12165565]
• Affinity Capture-MS [PMID 18239623]
• Affinity Capture-MS [PMID 16051665]
• Affinity Capture-MS [PMID 14559993]
• interacts with calcitonin/CGRP exon 4 exonic splice enhancer; required for calcitonin splicing in vitro [PMID 12531473]
• hTra2-beta1 expression in cervical cancer. The observed shuttle process of this splicing factor with higher concentrations in the nucleus effects on the cellular function and tumor biology, leading to the worse patient outcome. [PMID 19037821]

PubMed Articles

Recent articles:

• Kim W et al. “Systematic and quantitative assessment of the ubiquitin-modified proteome.” Mol Cell. 2011 Oct 21;44(2):325-40. PMID 21906983
• Wagner SA et al. “A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.” Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. PMID 21890473
• Pihlajamäki J et al. “Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis.” Cell Metab. 2011 Aug 3;14(2):208-18. PMID 21803291
• Ouyang YQ et al. “Expression levels of hnRNP G and hTra2-beta1 correlate with opposite outcomes in endometrial cancer biology.” Int J Cancer. 2011 May 1;128(9):2010-9. PMID 20607830
• Danielsen JM et al. “Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.” Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. PMID 21139048
• Tsuda K et al. “Structural basis for the dual RNA-recognition modes of human Tra2-β RRM.” Nucleic Acids Res. 2011 Mar;39(4):1538-53. PMID 20926394
• Elks CE et al. “Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.” Nat Genet. 2010 Dec;42(12):1077-85. PMID 21102462
• Hawkins PG et al. “Transcriptional regulation of Oct4 by a long non-coding RNA antisense to Oct4-pseudogene 5.” Transcription. 2010 Nov;1(3):165-175. PMID 21151833
• Krebs AR et al. “ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes.” EMBO Rep. 2010 Jul;11(7):541-7. PMID 20508642
• Hutchins JR et al. “Systematic analysis of human protein complexes identifies chromosome segregation proteins.” Science. 2010 Apr 30;328(5978):593-9. PMID 20360068

Top Pubmed articles linked to gene TRA2B matching any search term:

• Pihlajamäki J et al. “Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis.” Cell Metab. 2011 Aug 3;14(2):208-18. PMID 21803291
• Han F et al. “Melatonin ameliorates ischemic-like injury-evoked nitrosative stress: Involvement of HtrA2/PED pathways in endothelial cells.” J Pineal Res. 2011 Apr;50(3):281-91. PMID 21198825
• Thorleifsson G et al. “Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.” Nat Genet. 2009 Jan;41(1):18-24. PMID 19079260