EXPERIMENTAL

To a solution of compound (+)-31 (530 mg, 1.3 mmol) in Et₂O (30 mL) was added LiHMDS (1.70 mL, 1.0 M in THF, 1. mmol) at 0°C. This reaction mixture was warmed until reaching room temperature and stirred for 3.5 hours. After stirring, the mixture was cooled to 0°C and Tf₂O (479 mg, 1.7 mmol) was added dropwise. This mixture was warmed until reaching room temperature and then stirred for 1 hour. Next, the reaction mixture was quenched with 1N NaOH solution and extracted with Et₂O three times. The combined organic layers were washed with 1N NaOH solution, then washed with brine, then dried using anhydrous Na₂SO₄, filtered and concentrated. Flash chromatography (50:1 hexanes/EtOAc) provided compound (+)-32 (610 mg, 1.02 mmol, 90% yield).

To a solution of compound (+)-32 (610 mg, 1.02 mmol) in THF (34 mL) and NMP (1.7 mL) was added Fe(acac)₃ (36 mg, 0.1 mmol) and Pd(dppf)Cl₂•CH₂Cl₂ (41 mg, .05 mmol) at room temperature under N₂ protection. MeMgBr (1.35 mL, 3.0 M in diethyl ether, 4.06 mmol) was then added dropwise to the mixture. This was then stirred at room temperature for 2 hours. After stirring, the reaction was quenched with a saturated solution of NH₄Cl and extracted with Et₂O three times. The combined organic layers were dried over anhydrous Na₂SO₄, filtered and concentrated. Flash chromatography (40:1 hexanes/EtOAc) provided compound (+)-33 (452 mg, .97 mmol, 95% yield) as a colorless oil.