1002 Effect of Cisplatin-Titanate Nanoparticles on Composite-Tooth Bond Strength

Friday, March 23, 2012: 3:30 p.m. - 4:45 p.m.
Presentation Type: Poster Session
D. CHAN, Health Sciences Center, D322, University of Washington, Seattle, WA, K. CHUNG, Restorative Dentistry, University of Washington, Seattle, WA, and D.T. HOBBS, Savannah River National Laboratory, Aiken, SC
Objective: Nanoparticles of monosodium titanate (nMST) loaded with Cisplatin (nMST-CisPt) may reduce recurrent decay at tooth-composite margins through antibacterial properties. Our objective was to determine if adding nMST-CisPt to the All-Bond 2® adhesive system altered the shear bond strength of resin composite to enamel or dentin.

Method: nMSTs were synthesized using a sol-gel process and loaded with Cisplatin by a wet-chemistry method. Axial surfaces of 48 extracted human molars were prepared to create flat enamel or dentin surfaces  8mm in diameter and were divided into 3 groups. For enamel specimens, one etched surface was bonded with All-Bond 2® adhesive modified (10wt%) with nMST or nMST-CisPt; the other etched surface was a control using unaltered adhesive. For the dentin specimens, a similar protocol was followed except that the nMSTs or nMST-CisPt were added to the All-Bond 2® primer . Resin composite (FiltekTMSupreme Plus) was injected into a gel capsule and added perpendicularly to the coated specimen surface.  Specimens were light-cured for 120s and stored in water (37°C, 24h). Shear bond strength was measured with a universal testing machine (n=16, CHX=5mm/min) and the peak shear force at failure was recorded. Power analysis was used to calculate the minimum sample size required.  Differences among groups were identified using ANOVA and Tukey post-hoc analyses (a≤.05).

Result: The mean (SD) shear bond values ranged (all conditions) from 287 (70) to 307 (36) N. No statistically significant differences in failure force were observed among tested groups (P=0.70). Combined adhesive and cohesive failure patterns were observed with optical microscope.

Conclusion: Within the limitations of this study, the addition of either nMST or nMST-CisPt to All-Bond2® did not affect the shear bond strength between composite and human dentin or enamel.

This abstract is based on research that was funded entirely or partially by an outside source: DE021373-01

Keywords: Adhesion, Caries, Composites, Dentin bonding agents and Preventive dentistry