1129 Correlation between endotoxins and periapical periodontits

Friday, March 23, 2012: 3:30 p.m. - 4:45 p.m.
Presentation Type: Poster Session
A.C.C. XAVIER1, A. CHUNG1, C.A.T. CARVALHO2, L.D.D. OLIVEIRA2, M.C. VALERA3, A.O.C. JORGE4, and L.E. MAEKAWA4, 1Restorative Dentstry, Universidade Est. Paulista Julio Mesquita, Sao jose dos campos, Brazil, 2Universidade Est. Paulista Julio Mesquita, São José dos Campos, Brazil, 3UNESP, São José dos Campos, Brazil, 4Bioscience and Buccal Diagnosis, Universidade Est. Paulista Julio Mesquita, São Jose dos Campos, Brazil
Objectives: Analysis of the correlation between the amount of endotoxin and the diameter of the periapical periodontits in root canals with necrotic pulp tissue.

Methods: We conducted an initial periapical radiographs of 30 patients who had teeth with pulp necrosis and periapical lesionPatients were submited endodontic therapy and, immediately after the coronal openingsamples were collected from the root canals with paper conesThe largest diameter of lesions was calculated in millimeters and quantification of endotoxins were evaluated by the chromogenic Limulus lysate assay.

Results: The diameters of periapical lesions range from 1 to 12mm and the amount of endotoxins from 2.49 to 889 EU / mL. The data were subjected to statistical test of Pearson correlation, p = 0.043 and r = 0.372.

Conclusion: There is a positive correlation, however weak, between the amount of endotoxin and the diameter of the lesion. Thereforethe larger the diameter of the lesion the greater the amount of endotoxin present in the root canal.

This abstract is based on research that was funded entirely or partially by an outside source: FAPESP-2009/54621-0

Keywords: Digital image analysis, Endodontics, Infection, Pulpal disease and endotoxin