CARS

General Information

Full gene name:cysteinyl-tRNA synthetase Entrez Gene ID:833 Location:11p15.5 Synonyms:MGC:11246, CARS1, CYSRS Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs2237892	182401	downstream

NCBI Summary

This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010]

OMIM

OMIM ID:`OMIM ID 123859 `_

NCBI Phenotypes

• NHGRI GWA Catalog
• Joint influence of small-effect genetic variants on human longevity.

Gene Ontology

• tRNA aminoacylation for protein translation
• protein homodimerization activity
• cytosol
• cysteine-tRNA ligase activity
• cysteinyl-tRNA aminoacylation
• cytoplasm
• ATP binding
• protein binding
• tRNA binding
• gene expression
• metal ion binding

KEGG Pathways

• Aminoacyl-tRNA biosynthesis

GeneRIFs

• Affinity Capture-MS [PMID 19394292]
• CARS is a novel fusion partner of anaplastic lymphoma kinase in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor cases. [PMID 12112524]
• Observational study of gene-disease association. (HuGE Navigator) [PMID 20460425]
• Specificity of anticodon recognition by human CysRS is higher than that of its bacterial counterparts. [PMID 17303165]
• Affinity Capture-MS [PMID 21963094]
• Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) [PMID 20306291]
• Affinity Capture-MS [PMID 19041431]
• Affinity Capture-MS [PMID 19041431]
• Affinity Capture-MS [PMID 19041431]
• Affinity Capture-MS [PMID 19041431]
• Reconstituted Complex; Two-hybrid [PMID 10908348]

PubMed Articles

Recent articles:

• Kim W et al. “Systematic and quantitative assessment of the ubiquitin-modified proteome.” Mol Cell. 2011 Oct 21;44(2):325-40. PMID 21906983
• Emanuele MJ et al. “Global identification of modular cullin-RING ligase substrates.” Cell. 2011 Oct 14;147(2):459-74. PMID 21963094
• Danielsen JM et al. “Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.” Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. PMID 21139048
• Davis OS et al. “A three-stage genome-wide association study of general cognitive ability: hunting the small effects.” Behav Genet. 2010 Nov;40(6):759-67. PMID 20306291
• Yashin AI et al. “Joint influence of small-effect genetic variants on human longevity.” Aging (Albany NY). 2010 Sep;2(9):612-20. PMID 20834067
• Maeda S et al. “Replication study for the association between four Loci identified by a genome-wide association study on European American subjects with type 1 diabetes and susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes.” Diabetes. 2010 Aug;59(8):2075-9. PMID 20460425
• Edenberg HJ et al. “Genome-wide association study of alcohol dependence implicates a region on chromosome 11.” Alcohol Clin Exp Res. 2010 May;34(5):840-52. PMID 20201924
• Pezzolesi MG et al. “Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes.” Diabetes. 2009 Jun;58(6):1403-10. PMID 19252134
• Ouyang J et al. “Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.” Mol Cell. 2009 Apr 24;34(2):145-54. PMID 19394292
• Linkermann A et al. “Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes.” Biochim Biophys Acta. 2009 Feb;1794(2):168-76. PMID 19041431

Top Pubmed articles linked to gene CARS matching any search term:

• Ferro F et al. “Long-chain acylcarnitines regulate the HERG channel.” PLoS One. 2012;7(7):e41686. PMID 22848566
• Giraldo MA et al. “Land-use and land-cover assessment for the study of lifestyle change in a rural Mexican community: The Maycoba Project.” Int J Health Geogr. 2012 Jul 9;11(1):27. PMID 22776075
• Jarrett J et al. “Effect of increasing active travel in urban England and Wales on costs to the National Health Service.” Lancet. 2012 Jun 9;379(9832):2198-205. PMID 22682466
• Chumnanpuen P et al. “Lipid biosynthesis monitored at the single-cell level in Saccharomyces cerevisiae.” Biotechnol J. 2012 May;7(5):594-601. PMID 22442011
• Mauroy C et al. “Giant lipid vesicles under electric field pulses assessed by non invasive imaging.” Bioelectrochemistry. 2012 Apr 5;. PMID 22560131
• Hu C et al. “CPVL/CHN2 genetic variant is associated with diabetic retinopathy in Chinese type 2 diabetic patients.” Diabetes. 2011 Nov;60(11):3085-9. PMID 21911749
• Lee J et al. “Getting into the healthcare game. Companies outside of healthcare are pursuing innovative ways to enter the market.” Mod Healthc. 2011 Sep 19;41(38):31-2. PMID 21995141
• Owen N et al. “Adults’ sedentary behavior determinants and interventions.” Am J Prev Med. 2011 Aug;41(2):189-96. PMID 21767727
• Jang TW et al. “The association between impaired fasting glucose and noise-induced hearing loss.” J Occup Health. 2011;53(4):274-9. PMID 21670562
• Dassau E et al. “Closing the loop.” Int J Clin Pract Suppl. 2011 Feb;(170):20-5. PMID 21323809
• Maeda S et al. “Replication study for the association between four Loci identified by a genome-wide association study on European American subjects with type 1 diabetes and susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes.” Diabetes. 2010 Aug;59(8):2075-9. PMID 20460425
• Pezzolesi MG et al. “Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes.” Diabetes. 2009 Jun;58(6):1403-10. PMID 19252134