CREB5

General Information

Full gene name:cAMP responsive element binding protein 5 Entrez Gene ID:9586 Location:7p15.1 Synonyms:CRE-BPA Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs864745	158384	upstream

NCBI Summary

The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

OMIM

No OMIM data available for this gene.

NCBI Phenotypes

• NHGRI GWA Catalog
• Genome-wide meta-analysis for severe diabetic retinopathy.
• Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.

Gene Ontology

• protein binding
• protein dimerization activity
• zinc ion binding
• positive regulation of transcription, DNA-dependent
• nucleus
• sequence-specific DNA binding
• sequence-specific DNA binding transcription factor activity
• transcription from RNA polymerase II promoter

KEGG Pathways

• Cholinergic synapse
• Prostate cancer
• Huntington’s disease
• Amphetamine addiction
• Cocaine addiction
• Vasopressin-regulated water reabsorption
• Dopaminergic synapse
• Alcoholism

GeneRIFs

• Affinity Capture-MS [PMID 21890473]
• Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) [PMID 20379614]
• Reconstituted Complex [PMID 8440710]
• Reconstituted Complex [PMID 8440710]
• Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) [PMID 18519826]
• Observational study of gene-disease association. (HuGE Navigator) [PMID 20080650]

PubMed Articles

Recent articles:

• Wagner SA et al. “A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.” Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. PMID 21890473
• Grassi MA et al. “Genome-wide meta-analysis for severe diabetic retinopathy.” Hum Mol Genet. 2011 Jun 15;20(12):2472-81. PMID 21441570
• Reina Ortiz M et al. “Effects of chronic ascariasis and trichuriasis on cytokine production and gene expression in human blood: a cross-sectional study.” PLoS Negl Trop Dis. 2011 Jun;5(6):e1157. PMID 21666788
• Rose JE et al. “Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.” Mol Med. 2010 Jul-Aug;16(7-8):247-53. PMID 20379614
• Xu J et al. “Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.” Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2136-40. PMID 20080650
• Trynka G et al. “Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.” Gut. 2009 Aug;58(8):1078-83. PMID 19240061
• Lesch KP et al. “Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.” J Neural Transm. 2008 Nov;115(11):1573-85. PMID 18839057
• Uhl GR et al. “Molecular genetics of successful smoking cessation: convergent genome-wide association study results.” Arch Gen Psychiatry. 2008 Jun;65(6):683-93. PMID 18519826
• Gerhard DS et al. “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” Genome Res. 2004 Oct;14(10B):2121-7. PMID 15489334
• Ota T et al. “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Nat Genet. 2004 Jan;36(1):40-5. PMID 14702039

Top Pubmed articles linked to gene CREB5 matching any search term:

• Grassi MA et al. “Genome-wide meta-analysis for severe diabetic retinopathy.” Hum Mol Genet. 2011 Jun 15;20(12):2472-81. PMID 21441570
• Herrmann J et al. “Isomer-specific effects of CLA on gene expression in human adipose tissue depending on PPARgamma2 P12A polymorphism: a double blind, randomized, controlled cross-over study.” Lipids Health Dis. 2009 Aug 18;8:35. PMID 19689798