DUSP14

General Information

Full gene name:dual specificity phosphatase 14 Entrez Gene ID:11072 Location:17q12 Synonyms:MKP-L, MKP6 Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs757210	222927	downstream

NCBI Summary

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

OMIM

OMIM ID:`OMIM ID 606618 `_

NCBI Phenotypes

• NHGRI GWA Catalog
• Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.

Gene Ontology

• MAP kinase tyrosine/serine/threonine phosphatase activity
• protein tyrosine phosphatase activity
• peptidyl-tyrosine dephosphorylation
• protein tyrosine/serine/threonine phosphatase activity

KEGG Pathways

• MAPK signaling pathway

GeneRIFs

• Affinity Capture-Western; Reconstituted Complex; Two-hybrid [PMID 11123293]
• DUSP14 may be a susceptibility gene for pulmonary tuberculosis. [PMID 22233810]
• Activation of ATM by radiation down-regulates phospho-ERK1/2 and its downstream signaling via increased expression of mitogen-activated protein kinase phosphatase MKP-1. [PMID 17178844]
• Reconstituted Complex [PMID 21800051]
• The overproduction, purification and crystal structure at 1.88 A resolution of human dual-specificity phosphatase 14, DUSP14 (MKP6), are reported. [PMID 19770498]
• The binding of Lipomannan to TLR2 triggers MAPK activation, followed by an up-regulation of MKP-1 expression, which in turn may act as a negative regulator of MAPK activation. [PMID 18201568]
• Affinity Capture-MS [PMID 21906983]

PubMed Articles

Recent articles:

• Barreiro LB et al. “Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection.” Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1204-9. PMID 22233810
• Fang Y et al. “The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma.” Mol Cell Biochem. 2012 Jan;359(1-2):59-66. PMID 21800051
• Kim W et al. “Systematic and quantitative assessment of the ubiquitin-modified proteome.” Mol Cell. 2011 Oct 21;44(2):325-40. PMID 21906983
• Wagner SA et al. “A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.” Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. PMID 21890473
• Danielsen JM et al. “Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.” Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. PMID 21139048
• Thye T et al. “Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.” Nat Genet. 2010 Sep;42(9):739-41. PMID 20694014
• Lountos GT et al. “Overproduction, purification and structure determination of human dual-specificity phosphatase 14.” Acta Crystallogr D Biol Crystallogr. 2009 Oct;65(Pt 10):1013-20. PMID 19770498
• Patterson KI et al. “Dual-specificity phosphatases: critical regulators with diverse cellular targets.” Biochem J. 2009 Mar 15;418(3):475-89. PMID 19228121
• Elass E et al. “Mycobacterial lipomannan induces MAP kinase phosphatase-1 expression in macrophages.” FEBS Lett. 2008 Feb 6;582(3):445-50. PMID 18201568
• Nyati MK et al. “Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation.” Cancer Res. 2006 Dec 15;66(24):11554-9. PMID 17178844

Top Pubmed articles linked to gene DUSP14 matching any search term:

• Fang Y et al. “The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma.” Mol Cell Biochem. 2012 Jan;359(1-2):59-66. PMID 21800051
• Hendrix NW et al. “Prenatally diagnosed 17q12 microdeletion syndrome with a novel association with congenital diaphragmatic hernia.” Fetal Diagn Ther. 2012;31(2):129-33. PMID 22178801
• Klinger S et al. “Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14.” Diabetes. 2008 Mar;57(3):584-93. PMID 18025410