ESRP1
SNPs given by the user that are near or inside this gene:
| SNP |
Distance (bp) |
Direction |
|---|
| rs896854 |
240817 |
downstream |
ESPR1 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]
| OMIM ID: | `OMIM ID 612959
`_ |
|---|
No phenotypes found linked to this gene.
- nucleolus
- regulation of RNA splicing
- RNA splicing
- mRNA processing
- nucleus
- mRNA binding
- nucleotide binding
- plasma membrane
No pathways found linked to this gene.
- results further establish ESRP1 and ESRP2 as global regulators of an epithelial splicing regulatory network. [PMID 19829082]
- The FLJ20171 gene was shown to effectively separate these two chromophobe renal cell carcinoma (RCC) and benign oncocytoma groups by quantitative reverse transcription-PCR using fresh tissue samples, with similar trends seen on formalin-fixed tissues. [PMID 17145811]
- The functional significance of EMT-associated alternative splicing was tested by expression of the epithelial-specific splicing factor ESRP1 [PMID 21876675]
- ESRP1 coordinates a complex alternative splicing network that adds an important post-transcriptional layer to the changes in gene expression that underlie epithelial-mesenchymal transitions during development and disease. [PMID 20711167]
- functions of the ESRP1 in an epithelial posttranscriptional gene expression program. [PMID 22354987]
- ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. [PMID 19285943]
- Affinity Capture-MS [PMID 21906983]
- Results demonstrate that RBM35A functions as a tumor suppressor in colon cancer cells, and suggest that RBM35A is involved in posttranscriptional regulation of a number of genes by exerting a differential effect on protein translation via 5’UTRs of mRNAs. [PMID 19177006]
Recent articles:
- Dittmar KA et al. “Genome-wide determination of a broad ESRP-regulated posttranscriptional network by high-throughput sequencing.” Mol Cell Biol. 2012 Apr;32(8):1468-82. PMID 22354987
- Kim W et al. “Systematic and quantitative assessment of the ubiquitin-modified proteome.” Mol Cell. 2011 Oct 21;44(2):325-40. PMID 21906983
- Shapiro IM et al. “An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype.” PLoS Genet. 2011 Aug;7(8):e1002218. PMID 21876675
- Warzecha CC et al. “An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition.” EMBO J. 2010 Oct 6;29(19):3286-300. PMID 20711167
- Warzecha CC et al. “The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events.” RNA Biol. 2009 Nov-Dec;6(5):546-62. PMID 19829082
- Warzecha CC et al. “ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing.” Mol Cell. 2009 Mar 13;33(5):591-601. PMID 19285943
- Leontieva OV et al. “RNA-binding motif protein 35A is a novel tumor suppressor for colorectal cancer.” Cell Cycle. 2009 Feb 1;8(3):490-7. PMID 19177006
- Barbe L et al. “Toward a confocal subcellular atlas of the human proteome.” Mol Cell Proteomics. 2008 Mar;7(3):499-508. PMID 18029348
- Rohan S et al. “Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes.” Clin Cancer Res. 2006 Dec 1;12(23):6937-45. PMID 17145811
- Gerhard DS et al. “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” Genome Res. 2004 Oct;14(10B):2121-7. PMID 15489334