ETV5

General Information

Full gene name:ets variant 5 Entrez Gene ID:2119 Location:3q28 Synonyms:ERM Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs1470579	235026	downstream

NCBI Summary

None available.

OMIM

OMIM ID:`OMIM ID 601600 `_

NCBI Phenotypes

• Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
• Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
• NHGRI GWA Catalog
• Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.

Gene Ontology

• transcription regulatory region DNA binding
• DNA binding
• sequence-specific DNA binding transcription factor activity
• positive regulation of transcription, DNA-dependent
• cellular response to oxidative stress
• sequence-specific DNA binding
• regulation of transcription, DNA-dependent
• regulation of branching involved in mammary gland duct morphogenesis
• nucleus

KEGG Pathways

• Transcriptional misregulation in cancer

GeneRIFs

• Affinity Capture-Western [PMID 20062082]
• Pea3 and Erm, but not Er81, play an important role in the progression of esophageal squamous cell carcinoma [PMID 21689625]
• ERM has a role in progression of breast cancer [PMID 15534105]
• Reconstituted Complex [PMID 8798622]
• functional role for the ERMs (ezrin/radixin/moesin) as adaptor molecules in the interactions of adhesion receptors and intracellular tyrosine kinases [PMID 12387735]
• analysis of NHERF recognition by ERM proteins [PMID 16615918]
• CD44-mediated hyaluronan binding in myeloid cells is regulated by phosphorylated ERM and the actin cytoskeleton. [PMID 15652352]
• Upregulation of ETV5 induced the expression of cell adhesion molecules and enhanced cell survival in a spheroid model. [PMID 21520040]
• ERM is subject to SUMO modification and this post-translational modification causes inhibition of transcription-enhancing activity [PMID 15857832]
• results indicate concurrent mechanisms in expression of MMP-2 and -9, RUNX1/AML1 and ETV5/ERM, and several basement membrane components, which likely associate with the invasive stage of endometrioid endometrial and ovarian endometrioid carcinoma. [PMID 20970160]
• ERM/ETV5 up-regulation activates MMP-2 and thus has a role during myometrial infiltration in endometrial cancer [PMID 17638886]
• A TMPRSS2:ETV5 gene fusion was identified in prostate cancer. [PMID 18172298]
• Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) [PMID 20571754]
• Observational study of gene-disease association. (HuGE Navigator) [PMID 20816195]
• Testing various shorter fragments of ERM as bait indicated that the region essential for binding CHD3/ZFH is within the amino acid region 96-349, which contains the central inhibitory DNA-binding domain (CIDD) of ERM [PMID 17489097]
• Erm is involved in SP-C regulation, which results from an interaction with TTF-1 [PMID 16613858]
• The erm gene expression is regulated by the conventional PKC (cPKC) pathway. [PMID 15620692]
• Affinity Capture-MS; Affinity Capture-Western [PMID 21572435]
• Affinity Capture-MS [PMID 21693764]
• The flexible nature of transactivation domain may be instrumental for ERM recognition and binding to diverse molecular partners. [PMID 20647002]

PubMed Articles

Recent articles:

• Llauradó M et al. “ETV5 transcription factor is overexpressed in ovarian cancer and regulates cell adhesion in ovarian cancer cells.” Int J Cancer. 2012 Apr 1;130(7):1532-43. PMID 21520040
• Yuen HF et al. “The role of Pea3 group transcription factors in esophageal squamous cell carcinoma.” Am J Pathol. 2011 Aug;179(2):992-1003. PMID 21689625
• Tatham MH et al. “Comparative proteomic analysis identifies a role for SUMO in protein quality control.” Sci Signal. 2011 Jun 21;4(178):rs4. PMID 21693764
• Vitari AC et al. “COP1 is a tumour suppressor that causes degradation of ETS transcription factors.” Nature. 2011 May 15;474(7351):403-6. PMID 21572435
• Planagumà J et al. “Matrix metalloproteinase-2 and matrix metalloproteinase-9 codistribute with transcription factors RUNX1/AML1 and ETV5/ERM at the invasive front of endometrial and ovarian carcinoma.” Hum Pathol. 2011 Jan;42(1):57-67. PMID 20970160
• Elks CE et al. “Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.” Nat Genet. 2010 Dec;42(12):1077-85. PMID 21102462
• den Hoed M et al. “Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies.” Diabetes. 2010 Nov;59(11):2980-8. PMID 20724581
• Speliotes EK et al. “Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.” Nat Genet. 2010 Nov;42(11):937-48. PMID 20935630
• Melén E et al. “Analyses of shared genetic factors between asthma and obesity in children.” J Allergy Clin Immunol. 2010 Sep;126(3):631-7.e1-8. PMID 20816195
• Morgan AR et al. “Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.” BMC Med Genet. 2010 Aug 16;11:125. PMID 20712903

Top Pubmed articles linked to gene ETV5 matching any search term:

• Boender AJ et al. “Nutritional State Affects the Expression of the Obesity-Associated Genes Etv5, Faim2, Fto, and Negr1.” Obesity (Silver Spring). 2012 May 7;. PMID 22627920
• Breitfeld J et al. “Genetics of adiponectin.” Biochimie. 2012 Mar 15;. PMID 22449616
• Dorajoo R et al. “Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations.” Int J Obes (Lond). 2012 Jan;36(1):159-63. PMID 21544081
• Hotta K et al. “Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area.” J Hum Genet. 2011 Oct;56(10):716-9. PMID 21796141
• Sandholt CH et al. “Studies of metabolic phenotypic correlates of 15 obesity associated gene variants.” PLoS One. 2011;6(9):e23531. PMID 21912638
• Hotta K et al. “Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population.” J Hum Genet. 2011 Sep;56(9):647-51. PMID 21796137
• Lopez JP et al. “Glucose-induced ERM protein activation and translocation regulates insulin secretion.” Am J Physiol Endocrinol Metab. 2010 Nov;299(5):E772-85. PMID 20739507
• den Hoed M et al. “Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies.” Diabetes. 2010 Nov;59(11):2980-8. PMID 20724581
• Fontaine-Bisson B et al. “Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population.” Diabetologia. 2010 Oct;53(10):2155-62. PMID 20571754
• Morgan AR et al. “Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.” BMC Med Genet. 2010 Aug 16;11:125. PMID 20712903
• Ng MC et al. “Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese.” J Clin Endocrinol Metab. 2010 May;95(5):2418-25. PMID 20215397
• Cheung CY et al. “Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a chinese population.” J Clin Endocrinol Metab. 2010 Mar;95(3):1395-403. PMID 20061430
• Thorleifsson G et al. “Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.” Nat Genet. 2009 Jan;41(1):18-24. PMID 19079260
• Kobberup S et al. “ETS-family genes in pancreatic development.” Dev Dyn. 2007 Nov;236(11):3100-10. PMID 17907201