FES

General Information

Full gene name:feline sarcoma oncogene Entrez Gene ID:2242 Location:15q26.1 Synonyms:FPS Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs8042680	82331	downstream

NCBI Summary

This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]

OMIM

OMIM ID:`OMIM ID 190030 `_

NCBI Phenotypes

• Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
• Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
• NHGRI GWA Catalog

Gene Ontology

• positive regulation of myeloid cell differentiation
• Golgi apparatus
• microtubule cytoskeleton
• cytosol
• cytoplasm
• protein tyrosine kinase activity
• cytoplasmic membrane-bounded vesicle
• positive regulation of microtubule polymerization
• multicellular organismal development
• peptidyl-tyrosine phosphorylation
• cell proliferation
• extrinsic to internal side of plasma membrane
• regulation of cell shape
• axon guidance
• immunoglobulin receptor binding
• cytoplasmic vesicle
• positive regulation of neuron projection development
• focal adhesion
• ATP binding
• regulation of cell proliferation
• protein autophosphorylation
• regulation of cell motility
• regulation of cell adhesion
• positive regulation of actin cytoskeleton reorganization
• protein phosphorylation
• non-membrane spanning protein tyrosine kinase activity
• regulation of vesicle-mediated transport
• phosphatidylinositol binding
• regulation of mast cell degranulation
• regulation of cell differentiation

KEGG Pathways

• Axon guidance

GeneRIFs

• Affinity Capture-MS [PMID 17353931]
• Downregulation of the c-Fes protein-tyrosine kinase inhibits the proliferation of renal carcinoma. [PMID 19082481]
• Affinity Capture-Western [PMID 9714332]
• shows a major function of FES downstream of activated KIT receptor and thereby points to FES as a novel target in KIT-related pathologi [PMID 17595334]
• Reconstituted Complex [PMID 19953087]
• The SH2 and catalytic domains of active Fes and Abl pro-oncogenic kinases form integrated structures essential for effective tyrosine kinase signaling. [PMID 18775312]
• Fes naturally adopts an inactive conformation in vivo, and maintenance of the inactive structure requires the coiled-coil and SH2 domains. [PMID 12653561]
• Observational study of gene-disease association. (HuGE Navigator) [PMID 19913121]
• A novel Fes-KAP-1 interaction is reported, suggesting a dual role for KAP-1 as both a Fes activator and downstream effector. [PMID 16792528]
• Closing in on the biological functions of Fps/Fes and Fer. A review. [PMID 11994747]
• FPS mediates enhanced sensitization to VEGF and PDGF signaling in ECs; this hypersensitization contributes to excessive angiogenic signaling and underlies the observed hypervascular phenotype of human myristoylated FPS expressed in transgenic mice. [PMID 15099290]
• Reconstituted Complex [PMID 9222609]
• Reconstituted Complex [PMID 9222609]
• Reconstituted Complex [PMID 9222609]
• Reconstituted Complex [PMID 9222609]
• Reconstituted Complex [PMID 9222609]
• Reconstituted Complex [PMID 9222609]
• PEDF downregulates Fyn through Fes, resulting in inhibition of FGF-2-induced capillary morphogenesis of endothelial cells [PMID 15713745]
• Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) [PMID 20628086]
• NMR assignment of the SH2 domain [PMID 15630569]
• Affinity Capture-Western; Reconstituted Complex [PMID 10706130]
• Affinity Capture-MS [PMID 21890473]
• study shows Fes phosphorylates C-terminal tyrosine residues in HS1 implicated in actin stabilization; coordinated action of F-BAR & SH2 domains of Fes allow for coupling to FcepsilonRI signaling & potential regulation of actin reorganization in mast cells [PMID 19001085]
• Affinity Capture-Western; Biochemical Activity; Reconstituted Complex [PMID 8999909]
• Fes transduces inductive signals for terminal macrophage and granulocyte differentiation, and this biological activity is mediated through the activation of lineage-specific transcription factors. [PMID 15003822]
• Affinity Capture-Western; Biochemical Activity; Two-hybrid [PMID 11700021]
• c-Fes is a regulator of the tubulin cytoskeleton and may contribute to Fes-induced morphological changes in myeloid hematopoietic and neuronal cells [PMID 15485904]
• Affinity Capture-Western [PMID 8916957]
• NMR analysis of Src homology 2 domain from the human feline sarcoma oncogene Fes [PMID 15929003]
• Ezrin/Fes interaction at cell-cell contacts plays an essential role in hepatocyte growth factor-induced cell scattering and implicates Fes in the cross-talk between cell-cell and cell-matrix adhesion. [PMID 18046454]
• FGF-2 activates Fes via the second coiled-coil domain, leading to lamellipodium formation and chemotaxis by endothelial cells [PMID 19885553]
• FES kinase is a mediator of wild-type KIT signalling implicated in cell migration. [PMID 20117079]
• Two-hybrid [PMID 21900206]
• Two-hybrid [PMID 21900206]
• Two-hybrid [PMID 21900206]
• c-Fes oligomerization is independent of activation; data suggest that conformational changes, rather than oligomerization, govern c-Fes kinase activation and downstream signaling in vivo. [PMID 19382747]
• c-fes gene expression was found in myeloid leukemias, whereas low or no expression in lymphocytic leukemias. [PMID 20030920]
• Study of promoter methylation as important mechanism responsible for downregulation of FES gene expression in colorectal cancer cells. Treatment with DNA methyltransferase inhibitor resulted in expression of functional FES transcripts in CRC cell lines. [PMID 19051325]
• These novel results indicate the involvement of Fes in VEGF-A-induced cellular responses by cultured endothelial cells. [PMID 17521372]
• Fps/Fes and Fer are expressed in human and mouse platelets, and are activated following stimulation with collagen and collagen-related peptide (CRP), suggesting a role in GPVI receptor signaling [PMID 12871378]
• FES has a growth suppressive function in colorectal neoplasms. [PMID 16455651]

PubMed Articles

Recent articles:

• Wagner SA et al. “A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.” Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. PMID 21890473
• Wain LV et al. “Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.” Nat Genet. 2011 Sep 11;43(10):1005-11. PMID 21909110
• Ehret GB et al. “Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.” Nature. 2011 Sep 11;478(7367):103-9. PMID 21909115
• Vinayagam A et al. “A directed protein interaction network for investigating intracellular signal transduction.” Sci Signal. 2011 Sep 6;4(189):rs8. PMID 21900206
• Bailey SD et al. “Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.” Diabetes Care. 2010 Oct;33(10):2250-3. PMID 20628086
• Voisset E et al. “FES kinase participates in KIT-ligand induced chemotaxis.” Biochem Biophys Res Commun. 2010 Feb 26;393(1):174-8. PMID 20117079
• Kanda S et al. “Inhibition of endothelial cell chemotaxis toward FGF-2 by gefitinib associates with downregulation of Fes activity.” Int J Oncol. 2009 Dec;35(6):1305-12. PMID 19885553
• Zhang YL et al. “[Expression of c-fes gene in leukemia cells and its clinical significance].” Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Dec;17(6):1429-33. PMID 20030920
• Persaud A et al. “Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays.” Mol Syst Biol. 2009;5:333. PMID 19953087
• Talmud PJ et al. “Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.” Am J Hum Genet. 2009 Nov;85(5):628-42. PMID 19913121

Top Pubmed articles linked to gene FES matching any search term:

• Fowler AM et al. “Small-Animal PET of Steroid Hormone Receptors Predicts Tumor Response to Endocrine Therapy Using a Preclinical Model of Breast Cancer.” J Nucl Med. 2012 Jul;53(7):1119-26. PMID 22669982
• Tsujikawa T et al. “Oestrogen-related tumour phenotype: positron emission tomography characterisation with 18F-FDG and 18F-FES.” Br J Radiol. 2012 Jul;85(1015):1020-4. PMID 22337690
• Berraho M et al. “Hypertension and type 2 diabetes: a cross-sectional study in Morocco (EPIDIAM Study).” Pan Afr Med J. 2012;11:52. PMID 22593788
• Gorgey AS et al. “A report of anticipated benefits of functional electrical stimulation after spinal cord injury.” J Spinal Cord Med. 2012 Mar;35(2):107-12. PMID 22525324
• Le HT et al. “YajL, prokaryotic homolog of parkinsonism-associated protein DJ-1, functions as a covalent chaperone for thiol proteome.” J Biol Chem. 2012 Feb 17;287(8):5861-70. PMID 22157000
• Rojo-Botello NR et al. “Expression of toll-like receptors 2, 4 and 9 is increased in gingival tissue from patients with type 2 diabetes and chronic periodontitis.” J Periodontal Res. 2012 Feb;47(1):62-73. PMID 21848608
• Benatiya Andaloussi I et al. “[Orbito-palpebral necrotizing fasciitis complicating a pansinusitis in a patient with diabetes].” Pan Afr Med J. 2011;10:10. PMID 22187592
• Tekucheva DN et al. “Immobilized purple bacteria for light-driven H2 production from starch and potato fermentation effluents.” Biotechnol Prog. 2011 Sep-Oct;27(5):1248-56. PMID 21751433
• Kieffer-Kristensen R et al. “Parental stress and marital relationships among patients with brain injury and their spouses.” NeuroRehabilitation. 2011;28(4):321-30. PMID 21725165
• Ma WJ et al. “[Application of different nutrition therapies in pregnancy with abnormal glucose metabolism].” Zhonghua Yu Fang Yi Xue Za Zhi. 2011 May;45(5):426-9. PMID 21756786
• Bailey SD et al. “Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.” Diabetes Care. 2010 Oct;33(10):2250-3. PMID 20628086
• Jiang H et al. “Fes mediates the IL-4 activation of insulin receptor substrate-2 and cellular proliferation.” J Immunol. 2001 Feb 15;166(4):2627-34. PMID 11160325
• Jiang H et al. “IL-4/IL-13 signaling beyond JAK/STAT.” J Allergy Clin Immunol. 2000 Jun;105(6 Pt 1):1063-70. PMID 10856136