HAUS7

General Information

Full gene name:HAUS augmin-like complex, subunit 7 Entrez Gene ID:55559 Location:Xq28 Synonyms:UIP1, UCHL5IP, HSXQ28ORF Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs3020789	156384	upstream

NCBI Summary

This gene encodes a protein identified by interaction with ubiquitin C-terminal hydrolase 37, which functions to edit polyubiquitin chains on ubiquitinated substrates. This protein is a subunit of the multisubunit augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. [provided by RefSeq, Jul 2009]

OMIM

OMIM ID:`OMIM ID 300540 `_

NCBI Phenotypes

No phenotypes found linked to this gene.

Gene Ontology

• nucleolus
• HAUS complex
• centrosome organization
• cell division
• cytoplasm
• thioesterase binding
• microtubule
• mitosis
• spindle assembly
• spindle
• centrosome
• plasma membrane

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

• Dosage Lethality [PMID 22623531]
• Affinity Capture-MS [PMID 21906983]
• Affinity Capture-MS [PMID 20360068]
• Affinity Capture-MS [PMID 20360068]
• Affinity Capture-MS [PMID 20360068]
• Affinity Capture-MS [PMID 20360068]
• Affinity Capture-MS; Affinity Capture-Western [PMID 19369198]
• Affinity Capture-Western; Reconstituted Complex; Two-hybrid [PMID 11163772]

PubMed Articles

Recent articles:

• Toyoshima M et al. “Functional genomics identifies therapeutic targets for MYC-driven cancer.” Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9545-50. PMID 22623531
• Kim W et al. “Systematic and quantitative assessment of the ubiquitin-modified proteome.” Mol Cell. 2011 Oct 21;44(2):325-40. PMID 21906983
• Hutchins JR et al. “Systematic analysis of human protein complexes identifies chromosome segregation proteins.” Science. 2010 Apr 30;328(5978):593-9. PMID 20360068
• Xin X et al. “Shifted Transversal Design smart-pooling for high coverage interactome mapping.” Genome Res. 2009 Jul;19(7):1262-9. PMID 19447967
• Lawo S et al. “HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity.” Curr Biol. 2009 May 26;19(10):816-26. PMID 19427217
• Uehara R et al. “The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells.” Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):6998-7003. PMID 19369198
• Barbe L et al. “Toward a confocal subcellular atlas of the human proteome.” Mol Cell Proteomics. 2008 Mar;7(3):499-508. PMID 18029348
• Chen MJ et al. “Biochemical and cellular characteristics of the 3’ -> 5’ exonuclease TREX2.” Nucleic Acids Res. 2007;35(8):2682-94. PMID 17426129
• Hahn Y et al. “Human-specific nonsense mutations identified by genome sequence comparisons.” Hum Genet. 2006 Mar;119(1-2):169-78. PMID 16395595
• Mehrle A et al. “The LIFEdb database in 2006.” Nucleic Acids Res. 2006 Jan 1;34(Database issue):D415-8. PMID 16381901