HDDC3
SNPs given by the user that are near or inside this gene:
| SNP |
Distance (bp) |
Direction |
|---|
| rs8042680 |
45563 |
upstream |
No OMIM data available for this gene.
No phenotypes found linked to this gene.
- guanosine-3’,5’-bis(diphosphate) 3’-diphosphatase activity
- metal ion binding
- phosphoric diester hydrolase activity
- Affinity Capture-MS [PMID 21890473]
- Two-hybrid [PMID 16189514]
- Mesh1, encoded by HDDC3 in humans, contains an active site for ppGpp hydrolysis and a conserved His-Asp-box motif for Mn(2+) binding. It catalyzes hydrolysis of ppGpp both in vitro and in vivo. [PMID 20818390]
Recent articles:
- Wagner SA et al. “A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.” Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. PMID 21890473
- Sun D et al. “A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses.” Nat Struct Mol Biol. 2010 Oct;17(10):1188-94. PMID 20818390
- Lamesch P et al. “hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.” Genomics. 2007 Mar;89(3):307-15. PMID 17207965
- Zody MC et al. “Analysis of the DNA sequence and duplication history of human chromosome 15.” Nature. 2006 Mar 30;440(7084):671-5. PMID 16572171
- Rual JF et al. “Towards a proteome-scale map of the human protein-protein interaction network.” Nature. 2005 Oct 20;437(7062):1173-8. PMID 16189514
- Gerhard DS et al. “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” Genome Res. 2004 Oct;14(10B):2121-7. PMID 15489334
- Ota T et al. “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Nat Genet. 2004 Jan;36(1):40-5. PMID 14702039
- Strausberg RL et al. “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.” Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. PMID 12477932