IGF2BP2

General Information

Full gene name:insulin-like growth factor 2 mRNA binding protein 2 Entrez Gene ID:10644 Location:3q27.2 Synonyms:IMP2, p62, IMP-2, VICKZ2 Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs1470579	0	within

NCBI Summary

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains several four KH domains and two RRM domains. It functions by binding to the 5’ UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

OMIM

OMIM ID:`OMIM ID 608289 `_

Allelic Variants (Selected Examples)

.0001 DIABETES MELLITUS, NONINSULIN-DEPENDENT, SUSCEPTIBILITY TO

In genomewide association studies of type 2 DIABETES (125853), the DIABETES Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes for BioMedical Research (2007), Zeggini et al. (2007), and Scott et al. (2007) found that the T allele of rs4402960 confers increased susceptibility to type 2 DIABETES. Combined analyses obtained a P value of 8.9 x 10(-16).

NCBI Phenotypes

• Gene Reviews
• A genome-wide association study of gestational diabetes mellitus in Korean women.
• Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
• Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas.
• Diabetes mellitus type 2
• Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
• Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
• OMIM
• Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases.
• A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
• GTR
• Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
• Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
• NHGRI GWA Catalog
• SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations.
• Hundreds of variants clustered in genomic loci and biological pathways affect human height.

Gene Ontology

• cytosol
• protein binding
• regulation of cytokine biosynthetic process
• cytoskeletal part
• nucleus
• translation regulator activity
• cytoplasm
• mRNA 3’-UTR binding
• negative regulation of translation
• nucleotide binding
• mRNA 5’-UTR binding
• anatomical structure morphogenesis

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

• Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) [PMID 19401414]
• Affinity Capture-MS [PMID 17620599]
• Affinity Capture-MS [PMID 17353931]
• HMGA2 differentially regulates expression of IMP family members during mouse embryogenesis. [PMID 15225648]
• Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator) [PMID 20075150]
• Study suggests that there is a significant association between expression of IMP-2 and the growth of tumor cells, in which IMP-2 is associated with apoptosis induced by tretinoin. [PMID 15618018]
• Meta-analysis and HuGE review of gene-disease association. (HuGE Navigator) [PMID 19602701]
• VICKZ exhibits differential expression in lymphoma subtypes and thus may be a marker of potential value in the diagnosis and study of hematopoietic neoplasia. [PMID 17296566]
• Data reveal how the posttranscriptional regulation of gene expression by IMP-2 contributes to the control of adhesion structures and stable microtubules and demonstrate an important function for IMP-2 in cellular motility. [PMID 20956565]
• Variants of CDKAL1 and IGF2BP2 attenuate the first phase of glucose-stimulated insulin secretion but show no effect on the second phase of insulin secretion in hyperglycmia and type 2 diabetes. [PMID 18618095]
• involved in the selective autophagic clearance of non-ubiquitylated aggregation-prone substrates [PMID 21771882]
• Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) [PMID 20879858]
• we provide evidence that there is a strong and statistically significant correlation between HMGA2 and IMP2 gene expression in human liposarcomas. [PMID 17426251]
• Affinity Capture-MS [PMID 21906983]
• Affinity Capture-MS [PMID 17643375]
• Affinity Capture-MS [PMID 17643375]
• Affinity Capture-MS [PMID 17643375]
• non-replications of IGF2BP2 associations with type 2 diabetes [PMID 20627640]
• Little evidence of association was observed between SNPs in IGF2BP2 and type 2 diabetes in African Americans. [PMID 18443202]
• Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) [PMID 20628086]
• Six SNP(rs7754840 in CDKAL1, rs391300 in SRR, rs2383208 in CDKN2A/2B, rs4402960 in IGF2BP2, rs10830963 in MTNR1B, rs4607517 in GCK)risk alleles of type 2 diabetes were associated with GDM in pregnant Chinese women. [PMID 22096510]
• IGF2BP2 SNPs revealed a significant association with type 2 diabetes [PMID 18598350]
• findings show that IGF2BP2 rs1470579 and rs4402960 polymorphisms may be associated with the development of type 2 diabetes and these polymorphisms may affect the therapeutic efficacy of repaglinide in Chinese T2DM patientsmellitus [PMID 20523342]
• Affinity Capture-MS [PMID 20186120]
• Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) [PMID 20889853]
• IGF2BP2 stimulation increases radiosensitivity of a pancreatic cancer cell line through endoplasmic reticulum stress under hypoxic comditions. [PMID 19018773]
• The induction of a steatotic phenotype implies that p62 plays a role in hepatic pathophysiology [PMID 21145819]
• Type 2 diabetes susceptibility of IGF2BP2 was confirmed in Japanese. [PMID 19033397]
• Study show that polymorphisms in IGF2BP2 were associated with type 2 diabetes risk in the studied population. [PMID 18694974]
• Observational study of gene-disease association. (HuGE Navigator) [PMID 20929593]
• Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) [PMID 20802253]
• meta-analysis suggested that IGF2BP2 rs4402960 polymorphism conferred elevated risk of T2DM, especially in European, East Asian and South Asian populations [PMID 21839790]
• Double phosphorylation promotes IMP2 binding to the IGF2 leader 3 mRNA 5’ untranslated region, and the translational initiation of this mRNA [PMID 21576258]
• Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) [PMID 20203524]
• Affinity Capture-MS [PMID 17314511]
• The IGF2BP2 variant shows a nominal interaction with exposure to famine in wartime in utero and predisposition to type 2 diabetes. [PMID 19258437]
• Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) [PMID 17463249]
• Gene variants of CDKAL1, PPARG, IGF2BP2, HHEX, TCF7L2, and FTO predispose to type 2 diabetes in the German KORA 500 K study population. [PMID 18597214]
• Affinity Capture-MS [PMID 19135240]
• Affinity Capture-MS [PMID 22586326]
• IGF2BP2 single-nucleotide polymorphisms are associated with body fat and this effect on body fat influences insulin resistance which may contribute to type 2 diabetes mellitus risk. [PMID 19148120]
• Data show that SNPs in IGF2BP2 did not confer a significant risk for type 2 diabetes in Pima Indians. [PMID 19008344]
• Novel evidence for a rare variant in the 3’ downstream region of IGF2BP2 in type 2 diabetes in French Caucasians. [PMID 18430866]
• The results indicate that in Chinese Hans, common variants in IGF2BP2 loci independently or additively contribute to type 2 diabetes risk, likely mediated through beta-cell dysfunction. [PMID 18633108]
• Data confirmed the associations of single nucleotide polymorphisms in IGF2BP2 with risk for type 2 diabetes in Asians. [PMID 18469204]
• Observational study and meta-analysis of gene-disease association. (HuGE Navigator) [PMID 20490451]
• IGF2BP2 genetic variation is associated with type 2 diabetes. [PMID 22032244]
• The association of 6 loci with type 2 diabetes risk in Japanese patients is reported. [PMID 18162508]
• prostate cancer was inversely associated with the IGF2BP2 rs4402960 T allele [PMID 20142250]
• IGF2 is emerging as an important gene for ovarian cancer. [PMID 21422097]

PubMed Articles

Recent articles:

• Tsai YC et al. “Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.” Mol Cell Proteomics. 2012 May;11(5):60-76. PMID 22586326
• Perry JR et al. “Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.” PLoS Genet. 2012 May;8(5):e1002741. PMID 22693455
• Zhao Y et al. “IGF2BP2 genetic variation and type 2 diabetes: a global meta-analysis.” DNA Cell Biol. 2012 May;31(5):713-20. PMID 22032244
• Le HT et al. “Two isoforms of the mRNA binding protein IGF2BP2 are generated by alternative translational initiation.” PLoS One. 2012;7(3):e33140. PMID 22427968
• Kwak SH et al. “A genome-wide association study of gestational diabetes mellitus in Korean women.” Diabetes. 2012 Feb;61(2):531-41. PMID 22233651
• Wang Y et al. “Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a Chinese population.” PLoS One. 2011;6(11):e26953. PMID 22096510
• Kim W et al. “Systematic and quantitative assessment of the ubiquitin-modified proteome.” Mol Cell. 2011 Oct 21;44(2):325-40. PMID 21906983
• Wagner SA et al. “A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.” Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. PMID 21890473
• Watanabe Y et al. “p62/SQSTM1 in autophagic clearance of a non-ubiquitylated substrate.” J Cell Sci. 2011 Aug 15;124(Pt 16):2692-701. PMID 21771882
• Jia H et al. “Association between IGF2BP2 rs4402960 polymorphism and risk of type 2 diabetes mellitus: a meta-analysis.” Arch Med Res. 2011 Jul;42(5):361-7. PMID 21839790

Top Pubmed articles linked to gene IGF2BP2 matching any search term:

• Iwata M et al. “Genetic risk score constructed using 14 susceptibility alleles for type 2 diabetes is associated with the early onset of diabetes and may predict the future requirement of insulin injections among Japanese individuals.” Diabetes Care. 2012 Aug;35(8):1763-70. PMID 22688542
• Jia H et al. “Reply: Clarification of Data in the Recent Meta-analysis About Association Between IGF2BP2 rs4402960 Polymorphism And Risk of Type 2 Diabetes Mellitus.” Arch Med Res. 2012 Jul 24;. PMID 22841982
• Liu S et al. “Association Between IGF2BP2 rs4402960 Polymorphism And Risk of Type 2 Diabetes Mellitus: Need for Clarification of Data in a Recent Meta-analysis.” Arch Med Res. 2012 Jul 23;. PMID 22835599
• Gu T et al. “IGF2BP2 and IGF2 genetic effects in diabetes and diabetic nephropathy.” J Diabetes Complications. 2012 Jul 4;. PMID 22770937
• Schaeffer V et al. “RNA-binding protein IGF2BP2/IMP2 is required for laminin-β2 mRNA translation and is modulated by glucose concentration.” Am J Physiol Renal Physiol. 2012 Jul;303(1):F75-82. PMID 22513850
• Mtiraoui N et al. “Contribution of common variants of ENPP1, IGF2BP2, KCNJ11, MLXIPL, PPARγ, SLC30A8 and TCF7L2 to the risk of type 2 diabetes in Lebanese and Tunisian Arabs.” Diabetes Metab. 2012 Jun 27;. PMID 22749234
• Ekelund M et al. “Genetic prediction of postpartum diabetes in women with gestational diabetes mellitus.” Diabetes Res Clin Pract. 2012 May 14;. PMID 22591707
• Kurzawski M et al. “Analysis of common type 2 diabetes mellitus genetic risk factors in new-onset diabetes after transplantation in kidney transplant patients medicated with tacrolimus.” Eur J Clin Pharmacol. 2012 May 9;. PMID 22569928
• Perry JR et al. “Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.” PLoS Genet. 2012 May;8(5):e1002741. PMID 22693455
• Winkler C et al. “Lack of association of type 2 diabetes susceptibility genotypes and body weight on the development of islet autoimmunity and type 1 diabetes.” PLoS One. 2012;7(4):e35410. PMID 22558147
• Cauchi S et al. “European genetic variants associated with type 2 diabetes in North African Arabs.” Diabetes Metab. 2012 Mar 29;. PMID 22463974
• Wang Y et al. “Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a Chinese population.” PLoS One. 2011;6(11):e26953. PMID 22096510
• Boudoukha S et al. “Role of the RNA-binding protein IMP-2 in muscle cell motility.” Mol Cell Biol. 2010 Dec;30(24):5710-25. PMID 20956565
• Rotger M et al. “Impact of single nucleotide polymorphisms and of clinical risk factors on new‐onset diabetes mellitus in HIV‐infected individuals.” Clin Infect Dis. 2010 Nov 1;51(9):1090-8. PMID 20879858
• Bailey SD et al. “Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.” Diabetes Care. 2010 Oct;33(10):2250-3. PMID 20628086
• Stuebe AM et al. “Obesity and diabetes genetic variants associated with gestational weight gain.” Am J Obstet Gynecol. 2010 Sep;203(3):283.e1-17. PMID 20816152
• Pechlivanis S et al. “Coronary artery calcification and its relationship to validated genetic variants for diabetes mellitus assessed in the Heinz Nixdorf recall cohort.” Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1867-72. PMID 20616309
• Ruchat SM et al. “Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study.” Diabetologia. 2010 Apr;53(4):679-89. PMID 20043145
• Schulze MB et al. “Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam Study.” Diabetes Care. 2009 Nov;32(11):2116-9. PMID 19720844
• Grarup N et al. “Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies.” Diabetes. 2007 Dec;56(12):3105-11. PMID 17827400