INTS8

General Information

Full gene name:integrator complex subunit 8 Entrez Gene ID:55656 Location:8q22.1 Synonyms:INT8, C8orf52 Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs896854	67790	downstream

NCBI Summary

INTS8 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

OMIM

OMIM ID:`OMIM ID 611351 `_

NCBI Phenotypes

No phenotypes found linked to this gene.

Gene Ontology

• integrator complex
• protein binding
• snRNA processing

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

• Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) [PMID 20379614]
• Affinity Capture-MS [PMID 21906983]
• Affinity Capture-MS [PMID 20133760]
• Affinity Capture-MS [PMID 20133760]
• Affinity Capture-MS [PMID 20133760]
• Affinity Capture-MS [PMID 20133760]
• Affinity Capture-MS [PMID 16239144]
• Reconstituted Complex [PMID 16239144]
• Affinity Capture-MS [PMID 16239144]

PubMed Articles

Recent articles:

• Kim W et al. “Systematic and quantitative assessment of the ubiquitin-modified proteome.” Mol Cell. 2011 Oct 21;44(2):325-40. PMID 21906983
• Danielsen JM et al. “Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.” Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. PMID 21139048
• Rose JE et al. “Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.” Mol Med. 2010 Jul-Aug;16(7-8):247-53. PMID 20379614
• Malovannaya A et al. “Streamlined analysis schema for high-throughput identification of endogenous protein complexes.” Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2431-6. PMID 20133760
• Olsen JV et al. “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.” Cell. 2006 Nov 3;127(3):635-48. PMID 17081983
• Baillat D et al. “Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.” Cell. 2005 Oct 21;123(2):265-76. PMID 16239144
• Gerhard DS et al. “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” Genome Res. 2004 Oct;14(10B):2121-7. PMID 15489334
• Ota T et al. “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Nat Genet. 2004 Jan;36(1):40-5. PMID 14702039
• Strausberg RL et al. “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.” Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. PMID 12477932
• Hillier LD et al. “Generation and analysis of 280,000 human expressed sequence tags.” Genome Res. 1996 Sep;6(9):807-28. PMID 8889549