JAKMIP1

General Information

Full gene name:janus kinase and microtubule interacting protein 1 Entrez Gene ID:152789 Location:4p16.1 Synonyms:Gababrbp, MARLIN1, JAMIP1 Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs10010131	90597	upstream

NCBI Summary

None available.

OMIM

OMIM ID:`OMIM ID 611195 `_

NCBI Phenotypes

• NHGRI GWA Catalog
• Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.

Gene Ontology

• ribonucleoprotein complex
• microtubule
• RNA binding
• GABA receptor binding
• extrinsic to membrane
• cytoplasm
• protein transport
• kinase binding
• microtubule binding

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

• Marlin-1 functions to regulate the cellular levels of GABA(B) R2 subunits, which may have significant effects on the production of functional GABA(B) receptor heterodimers [PMID 14718537]
• Affinity Capture-Western; Reconstituted Complex [PMID 14718537]
• We have identified four new transcripts of 2975 bp, 1743 bp, 2189 bp and 2420 bp respectively, named Jakmip1B, Jakmip1C, Jakmip1D and Jakmip1E [PMID 17761393]
• Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) [PMID 20379614]
• Observational study of gene-disease association. (HuGE Navigator) [PMID 17804789]
• Marlin1 has a role in cell polarization, segregation of signaling complexes, and vesicle traffic, some of which may involve Jak tyrosine kinases [PMID 15277531]
• Jamip1 interacts with Tyk2. [PMID 15277531]
• Jamip1 interacts with Jamip1. [PMID 15277531]
• Jamip1 interacts with Jak1. [PMID 15277531]
• Jakmip1 is a novel effector memory gene that restrains T cell-mediated cytotoxicity. [PMID 18941173]

PubMed Articles

Recent articles:

• Turner ST et al. “Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.” Hypertension. 2012 Jun;59(6):1204-11. PMID 22566498
• Rose JE et al. “Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.” Mol Med. 2010 Jul-Aug;16(7-8):247-53. PMID 20379614
• Libri V et al. “Jakmip1 is expressed upon T cell differentiation and has an inhibitory function in cytotoxic T lymphocytes.” J Immunol. 2008 Nov 1;181(9):5847-56. PMID 18941173
• Costa V et al. “Identification and expression analysis of novel Jakmip1 transcripts.” Gene. 2007 Nov 1;402(1-2):1-8. PMID 17761393
• Raelson JV et al. “Genome-wide association study for Crohn’s disease in the Quebec Founder Population identifies multiple validated disease loci.” Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14747-52. PMID 17804789
• Cruz-Garcia D et al. “Identification and characterization of two novel (neuro)endocrine long coiled-coil proteins.” FEBS Lett. 2007 Jul 10;581(17):3149-56. PMID 17572408
• Kimura K et al. “Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.” Genome Res. 2006 Jan;16(1):55-65. PMID 16344560
• Steindler C et al. “Jamip1 (marlin-1) defines a family of proteins interacting with janus kinases and microtubules.” J Biol Chem. 2004 Oct 8;279(41):43168-77. PMID 15277531
• Jin J et al. “Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.” Curr Biol. 2004 Aug 24;14(16):1436-50. PMID 15324660
• Couve A et al. “Marlin-1, a novel RNA-binding protein associates with GABA receptors.” J Biol Chem. 2004 Apr 2;279(14):13934-43. PMID 14718537