KLF14

General Information

Full gene name:Kruppel-like factor 14 Entrez Gene ID:136259 Location:7q32.3 Synonyms:BTEB5 Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs972283	47966	upstream

NCBI Summary

This gene encodes a member of the Kruppel-like family of transcription factors. The gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. Expression of this gene is induced by TGF-beta, and the protein represses TGF-beta receptor II expression. The protein functions as part of a transcriptional co-repressor complex that also contains the transcriptional regulator SIN3A and histone deacetylase 2. [provided by RefSeq, Nov 2009]

OMIM

OMIM ID:`OMIM ID 608613 `_

NCBI Phenotypes

• Biological, clinical and population relevance of 95 loci for blood lipids.
• Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
• NHGRI GWA Catalog

Gene Ontology

• DNA binding
• nucleus
• transcription, DNA-dependent
• regulation of transcription, DNA-dependent
• zinc ion binding

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

• Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) [PMID 20889853]
• Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) [PMID 19936222]
• Observational study of gene-disease association. (HuGE Navigator) [PMID 19578363]
• KLF14 gene is imprinted, with preferential expression from the maternal allele. [PMID 17480121]
• we show that the type 2 diabetes and high-density lipoprotein cholesterol-associated cis-acting expression quantitative trait locus (eQTL) of the maternally expressed transcription factor KLF14 acts as a master trans regulator of adipose gene expression [PMID 21572415]
• Affinity Capture-MS [PMID 21906983]
• the TGFbeta pathway activation leads to recruitment of a KLF14-mSin3A-HDAC2 repressor complex to the TGFbetaRII promoter, as well as the remodeling of chromatin to increase histone marks that associate with transcriptional silencing. [PMID 19088080]

PubMed Articles

Recent articles:

• Kim W et al. “Systematic and quantitative assessment of the ubiquitin-modified proteome.” Mol Cell. 2011 Oct 21;44(2):325-40. PMID 21906983
• Small KS et al. “Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes.” Nat Genet. 2011 Jun;43(6):561-4. PMID 21572415
• de Miguel-Yanes JM et al. “Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.” Diabetes Care. 2011 Jan;34(1):121-5. PMID 20889853
• Teslovich TM et al. “Biological, clinical and population relevance of 95 loci for blood lipids.” Nature. 2010 Aug 5;466(7307):707-13. PMID 20686565
• Voight BF et al. “Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.” Nat Genet. 2010 Jul;42(7):579-89. PMID 20581827
• Chasman DI et al. “Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.” PLoS Genet. 2009 Nov;5(11):e1000730. PMID 19936222
• Stacey SN et al. “New common variants affecting susceptibility to basal cell carcinoma.” Nat Genet. 2009 Aug;41(8):909-14. PMID 19578363
• Truty MJ et al. “Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling.” J Biol Chem. 2009 Mar 6;284(10):6291-300. PMID 19088080
• Parker-Katiraee L et al. “Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution.” PLoS Genet. 2007 May 4;3(5):e65. PMID 17480121
• Suske G et al. “Mammalian SP/KLF transcription factors: bring in the family.” Genomics. 2005 May;85(5):551-6. PMID 15820306

Top Pubmed articles linked to gene KLF14 matching any search term:

• Chen G et al. “Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans.” Hum Mol Genet. 2012 Jul 30;. PMID 22791750
• Ohshige T et al. “Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese.” PLoS One. 2011;6(10):e26911. PMID 22046406
• Zhang J et al. “Regulation of fat storage and reproduction by Krüppel-like transcription factor KLF3 and fat-associated genes in Caenorhabditis elegans.” J Mol Biol. 2011 Aug 19;411(3):537-53. PMID 21704635
• Rees SD et al. “Replication of 13 genome-wide association (GWA)-validated risk variants for type 2 diabetes in Pakistani populations.” Diabetologia. 2011 Jun;54(6):1368-74. PMID 21350842
• Small KS et al. “Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes.” Nat Genet. 2011 Jun;43(6):561-4. PMID 21572415
• Nielsen T et al. “Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release.” Diabetologia. 2011 May;54(5):1052-6. PMID 21267535
• de Miguel-Yanes JM et al. “Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.” Diabetes Care. 2011 Jan;34(1):121-5. PMID 20889853
• Voight BF et al. “Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.” Nat Genet. 2010 Jul;42(7):579-89. PMID 20581827