MAN2A2

General Information

Full gene name:mannosidase, alpha, class 2A, member 2 Entrez Gene ID:4122 Location:15q26.1 Synonyms:MANA2X Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs8042680	55522	downstream

NCBI Summary

None available.

OMIM

OMIM ID:`OMIM ID 600988 `_

NCBI Phenotypes

• NHGRI GWA Catalog
• Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.

Gene Ontology

• carbohydrate binding
• cellular protein metabolic process
• carbohydrate metabolic process
• zinc ion binding
• protein N-linked glycosylation via asparagine
• mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
• integral to membrane
• post-translational protein modification
• Golgi membrane
• mannose metabolic process

KEGG Pathways

• N-Glycan biosynthesis
• Metabolic pathways

GeneRIFs

• Specific alterations of the N-linked carbohydrates on HIV-1 gp120 and gp41 by glucosidases and mannosidase inhibitors can enhance mannose-binding lectin (MBL)-mediated neutralization of virus by strengthening the interaction of HIV-1 with MBL [PMID 12560567]
• Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus [PMID 11530211]
• Two-hybrid [PMID 16169070]
• Two-hybrid [PMID 16169070]
• Two-hybrid [PMID 16169070]
• Two-hybrid [PMID 16169070]
• Two-hybrid [PMID 16169070]
• Mannose-containing, N-linked oligosaccharide side-chains of HIV-1 gp41 are involved in the initial stage of infection by HIV-1; glycosylation inhibitors block virus-cell and cell-cell fusion and release of the virions [PMID 8093218]
• HIV-1 gp120 N-linked oligosaccharides are processed by manosidase I and II in the Golgi complex [PMID 8892864]

PubMed Articles

Recent articles:

• Lesch KP et al. “Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.” J Neural Transm. 2008 Nov;115(11):1573-85. PMID 18839057
• Stelzl U et al. “A human protein-protein interaction network: a resource for annotating the proteome.” Cell. 2005 Sep 23;122(6):957-68. PMID 16169070
• Hillman RT et al. “An unappreciated role for RNA surveillance.” Genome Biol. 2004;5(2):R8. PMID 14759258
• Hart ML et al. “Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin.” J Gen Virol. 2003 Feb;84(Pt 2):353-60. PMID 12560567
• Strausberg RL et al. “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.” Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. PMID 12477932
• Land A et al. “Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum.” Biochimie. 2001 Aug;83(8):783-90. PMID 11530211
• Papandreou MJ et al. “Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation.” FEBS Lett. 1997 Apr 7;406(1-2):191-5. PMID 9109416
• Hu H et al. “Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface.” J Virol. 1996 Nov;70(11):7462-70. PMID 8892864
• Bolmstedt A et al. “Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response.” J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jul;12(3):213-20. PMID 8673525
• Misago M et al. “Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme.” Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11766-70. PMID 8524845

Top Pubmed articles linked to gene MAN2A2 matching any search term:

• Pal R et al. “Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1.” Proc Natl Acad Sci U S A. 1989 May;86(9):3384-8. PMID 2541446
• Blough HA et al. “Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins.” Biochem Biophys Res Commun. 1986 Nov 26;141(1):33-8. PMID 3099781