MIR548A2

General Information

Full gene name:microRNA 548a-2 Entrez Gene ID:693126 Location:6 Synonyms:MIRN548A2 Type:miscRNA

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs4607103	0	within

NCBI Summary

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

OMIM

No OMIM data available for this gene.

NCBI Phenotypes

No phenotypes found linked to this gene.

Gene Ontology

No GO terms found linked to this gene.

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

None available.

PubMed Articles

Recent articles:

• Landgraf P et al. “A mammalian microRNA expression atlas based on small RNA library sequencing.” Cell. 2007 Jun 29;129(7):1401-14. PMID 17604727
• Cummins JM et al. “The colorectal microRNAome.” Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3687-92. PMID 16505370
• Griffiths-Jones S et al. “miRBase: microRNA sequences, targets and gene nomenclature.” Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4. PMID 16381832