MKRN2

General Information

Full gene name:makorin ring finger protein 2 Entrez Gene ID:23609 Location:3p25 Synonyms:HSPC070, RNF62 Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs1801282	205469	upstream

NCBI Summary

Members of the makorin family, including MKRN2, have a characteristic zinc finger composition that suggests that they are ribonucleoproteins (Gray et al., 2001 [PubMed 11597136]).[supplied by OMIM, Mar 2008]

OMIM

OMIM ID:`OMIM ID 608426 `_

NCBI Phenotypes

No phenotypes found linked to this gene.

Gene Ontology

• nucleic acid binding
• intracellular
• molecular_function
• zinc ion binding
• ligase activity
• biological_process
• protein ubiquitination

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

• Two-hybrid [PMID 19549727]
• Affinity Capture-MS [PMID 22118674]
• MKRN2 and RAF1 are co-expressed in tissues and cell lines [PMID 11597136]
• Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) [PMID 21048031]

PubMed Articles

Recent articles:

• Altun M et al. “Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.” Chem Biol. 2011 Nov 23;18(11):1401-12. PMID 22118674
• Danielsen JM et al. “Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.” Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. PMID 21139048
• Casabonne D et al. “Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.” Haematologica. 2011 Feb;96(2):323-7. PMID 21048031
• Markson G et al. “Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.” Genome Res. 2009 Oct;19(10):1905-11. PMID 19549727
• Gerhard DS et al. “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” Genome Res. 2004 Oct;14(10B):2121-7. PMID 15489334
• Ota T et al. “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Nat Genet. 2004 Jan;36(1):40-5. PMID 14702039
• Strausberg RL et al. “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.” Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. PMID 12477932
• Gray TA et al. “Phylogenetic conservation of the makorin-2 gene, encoding a multiple zinc-finger protein, antisense to the RAF1 proto-oncogene.” Genomics. 2001 Oct;77(3):119-26. PMID 11597136
• Zhang QH et al. “Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.” Genome Res. 2000 Oct;10(10):1546-60. PMID 11042152