NAP1L4

General Information

Full gene name:nucleosome assembly protein 1-like 4 Entrez Gene ID:4676 Location:11p15.5 Synonyms:NAP2L, NAP1L4b, hNAP2, NAP2 Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs2237892	125909	downstream

NCBI Summary

This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. [provided by RefSeq, Jul 2008]

OMIM

OMIM ID:`OMIM ID 601651 `_

NCBI Phenotypes

• Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels.
• NHGRI GWA Catalog

Gene Ontology

• cytoplasm
• chromatin assembly complex
• unfolded protein binding
• nucleosome assembly

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

• The biochemical properties of two human NAP1-like proteins, hNAP1L1 and hNAP1L4, were characterized. [PMID 20002496]
• Affinity Capture-MS [PMID 19135240]
• Reconstituted Complex [PMID 11073993]
• Reconstituted Complex [PMID 11073993]
• Reconstituted Complex [PMID 11073993]
• Affinity Capture-Western; Reconstituted Complex; Two-hybrid [PMID 11073993]
• NAP-2 is in complex(es) with other proteins, which are distinct from histones [PMID 15368365]
• Results identified several proteins interacting with NAP1L2, including the ubiquitously expressed members of the nucleosome assembly protein family, NAP1L1 and NAP1L4. [PMID 21333655]
• Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) [PMID 20201924]
• Affinity Capture-MS [PMID 20360068]
• Reconstituted Complex [PMID 9325046]
• Reconstituted Complex [PMID 9325046]
• Reconstituted Complex [PMID 9325046]
• Reconstituted Complex [PMID 9325046]
• Reconstituted Complex [PMID 9325046]
• Telomeric NAP1L4 and OSBPL5 of the KCNQ1 cluster, and the DECORIN gene are not imprinted in human trophoblast stem cells. [PMID 20644730]
• HIV-1 gp120 modulates expression of the chemokines, GRO-alpha (CXCL1), GRO-gamma, NAP2, IL-8, IP-10, MIP-1beta, MIP-1alpha, RANTES, and MIP-3alpha, in PBMCs and MDMs [PMID 12089333]
• Human Nap2 promotes nucleosome assembly with H3t/H4. [PMID 18281699]
• Affinity Capture-MS [PMID 21906983]

PubMed Articles

Recent articles:

• Kim W et al. “Systematic and quantitative assessment of the ubiquitin-modified proteome.” Mol Cell. 2011 Oct 21;44(2):325-40. PMID 21906983
• Wagner SA et al. “A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.” Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. PMID 21890473
• Attia M et al. “Interaction between nucleosome assembly protein 1-like family members.” J Mol Biol. 2011 Apr 15;407(5):647-60. PMID 21333655
• Danielsen JM et al. “Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.” Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. PMID 21139048
• O’Seaghdha CM et al. “Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels.” Hum Mol Genet. 2010 Nov 1;19(21):4296-303. PMID 20705733
• Frost JM et al. “Telomeric NAP1L4 and OSBPL5 of the KCNQ1 cluster, and the DECORIN gene are not imprinted in human trophoblast stem cells.” PLoS One. 2010 Jul 14;5(7):e11595. PMID 20644730
• Edenberg HJ et al. “Genome-wide association study of alcohol dependence implicates a region on chromosome 11.” Alcohol Clin Exp Res. 2010 May;34(5):840-52. PMID 20201924
• Hutchins JR et al. “Systematic analysis of human protein complexes identifies chromosome segregation proteins.” Science. 2010 Apr 30;328(5978):593-9. PMID 20360068
• Okuwaki M et al. “Functional characterization of human nucleosome assembly protein 1-like proteins as histone chaperones.” Genes Cells. 2010 Jan;15(1):13-27. PMID 20002496
• Sumara G et al. “Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis.” Cell. 2009 Jan 23;136(2):235-48. PMID 19135240

Top Pubmed articles linked to gene NAP1L4 matching any search term:

• Sumara G et al. “Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis.” Cell. 2009 Jan 23;136(2):235-48. PMID 19135240
• Catchpoole D et al. “Mutation analysis of H19 and NAP1L4 (hNAP2) candidate genes and IGF2 DMR2 in Beckwith-Wiedemann syndrome.” J Med Genet. 2000 Mar;37(3):212-5. PMID 10777363
• Hu RJ et al. “A novel human homologue of yeast nucleosome assembly protein, 65 kb centromeric to the p57KIP2 gene, is biallelically expressed in fetal and adult tissues.” Hum Mol Genet. 1996 Nov;5(11):1743-8. PMID 8923002