NCR3LG1
SNPs given by the user that are near or inside this gene:
| SNP |
Distance (bp) |
Direction |
|---|
| rs5215 |
9762 |
downstream |
B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]).[supplied by OMIM, Jan 2011]
No OMIM data available for this gene.
No phenotypes found linked to this gene.
- plasma membrane
- viral capsid
- integral to membrane
- structural molecule activity
No pathways found linked to this gene.
- The NKp30-B7-H6 structure revealed that this NK cell activating complex is distinct from the CTLA4-B7 and PD-1-PD-L T cell inhibitory complexes in both overall organization and detailed atomic interactions that mediate binding and specificity. [PMID 21422170]
- Affinity Capture-MS [PMID 21875946]
- DKFZp686O24166 was designated the gene B7-H6; identification as a tumor cell surface molecule that binds NKp30, a receptor which triggers antitumor NK cell cytotoxicity and cytokine secretion [PMID 19528259]
Recent articles:
- Kaifu T et al. “B7-H6/NKp30 interaction: a mechanism of alerting NK cells against tumors.” Cell Mol Life Sci. 2011 Nov;68(21):3531-9. PMID 21877119
- Berndt JD et al. “Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.” J Cell Biol. 2011 Sep 5;194(5):737-50. PMID 21875946
- Joyce MG et al. “Crystal structure of human natural cytotoxicity receptor NKp30 and identification of its ligand binding site.” Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6223-8. PMID 21444796
- Li Y et al. “Structure of the human activating natural cytotoxicity receptor NKp30 bound to its tumor cell ligand B7-H6.” J Exp Med. 2011 Apr 11;208(4):703-14. PMID 21422170
- Brandt CS et al. “The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans.” J Exp Med. 2009 Jul 6;206(7):1495-503. PMID 19528259
- Strausberg RL et al. “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.” Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. PMID 12477932