OASL

General Information

Full gene name:2’-5’-oligoadenylate synthetase-like Entrez Gene ID:8638 Location:12q24.2 Synonyms:p59OASL, p59 OASL, p59-OASL, OASLd, TRIP14, TRIP-14 Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs7957197	0	within

NCBI Summary

None available.

OMIM

OMIM ID:`OMIM ID 603281 `_

NCBI Phenotypes

• Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
• Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
• Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
• NHGRI GWA Catalog

Gene Ontology

• negative regulation of viral genome replication
• nucleolus
• response to virus
• 2’-5’-oligoadenylate synthetase activity
• cytosol
• cytoplasm
• double-stranded RNA binding
• DNA binding
• ATP binding
• biological_process
• thyroid hormone receptor binding
• type I interferon-mediated signaling pathway
• interferon-gamma-mediated signaling pathway
• cytokine-mediated signaling pathway

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

• Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) [PMID 20889853]
• Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) [PMID 19559055]
• Affinity Capture-MS [PMID 22586326]
• The pronounced difference in gene regulation between the OASL gene agrees with a functional difference between these genes, which must exist as a consequence of the lack of the 2-5A synthetase activity of the OASL protein. [PMID 19203244]
• Proof that OASL is an antiviral protein that works through a novel mechanism distinct from other OASL proteins in other vertebrate species. [PMID 18931074]
• variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits [PMID 21943158]
• OASLa, a major isoform of OASL induced in human liver, may mediate anti-HCV activity through two different domains. [PMID 20074559]
• Observational study of gene-disease association. (HuGE Navigator) [PMID 21050126]
• Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) [PMID 20379614]
• Affinity Capture-MS [PMID 21987572]
• The expression of OASL and IFIT2 was significantly higher in SLE patients than in controls. [PMID 20506645]
• interaction with methyl CpG-binding protein 1 was confirmed in vitro and in vivo and was mapped to the ubiquitin-like domain of p59 OASL [PMID 14728690]

PubMed Articles

Recent articles:

• Guo X et al. “Identification of OASL d, a splice variant of human OASL, with antiviral activity.” Int J Biochem Cell Biol. 2012 Jul;44(7):1133-8. PMID 22531715
• Tsai YC et al. “Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.” Mol Cell Proteomics. 2012 May;11(5):60-76. PMID 22586326
• Lee KA et al. “Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.” J Biol Chem. 2011 Dec 2;286(48):41530-8. PMID 21987572
• Middelberg RP et al. “Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.” BMC Med Genet. 2011 Sep 24;12:123. PMID 21943158
• de Miguel-Yanes JM et al. “Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.” Diabetes Care. 2011 Jan;34(1):121-5. PMID 20889853
• Lauc G et al. “Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.” PLoS Genet. 2010 Dec 23;6(12):e1001256. PMID 21203500
• Barkhash AV et al. “Variability in the 2’-5’-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease.” J Infect Dis. 2010 Dec 15;202(12):1813-8. PMID 21050126
• Silva LK et al. “Dengue hemorrhagic fever is associated with polymorphisms in JAK1.” Eur J Hum Genet. 2010 Nov;18(11):1221-7. PMID 20588308
• Voight BF et al. “Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.” Nat Genet. 2010 Jul;42(7):579-89. PMID 20581827
• Zhao ZY et al. “[Interferon-inducible genes 2’, 5’-ollgoadenylate synthetase-like and tetratricopeptide repeats 2 are correlated with clinical features of patients with systemic lupus erythematosus].” Sichuan Da Xue Xue Bao Yi Xue Ban. 2010 Mar;41(2):247-51. PMID 20506645

Top Pubmed articles linked to gene OASL matching any search term:

• Middelberg RP et al. “Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.” BMC Med Genet. 2011 Sep 24;12:123. PMID 21943158
• de Miguel-Yanes JM et al. “Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.” Diabetes Care. 2011 Jan;34(1):121-5. PMID 20889853
• Voight BF et al. “Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.” Nat Genet. 2010 Jul;42(7):579-89. PMID 20581827