PDE2A

General Information

Full gene name:phosphodiesterase 2A, cGMP-stimulated Entrez Gene ID:5138 Location:11q13.4 Synonyms:PDE2A1, PED2A4, cGSPDE, CGS-PDE Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs1552224	47604	upstream

NCBI Summary

None available.

OMIM

OMIM ID:`OMIM ID 602658 `_

NCBI Phenotypes

• Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.
• Genome-wide association identifies ATOH7 as a major gene determining human optic disc size.
• NHGRI GWA Catalog

Gene Ontology

• cAMP-mediated signaling
• cGMP catabolic process
• protein homodimerization activity
• calcium channel activity
• cytosol
• cytoplasm
• negative regulation of cAMP biosynthetic process
• metabolic process
• negative regulation of protein import into nucleus, translocation
• cAMP catabolic process
• plasma membrane
• blood coagulation
• drug binding
• cellular response to cGMP
• cAMP binding
• Golgi apparatus
• protein binding
• endoplasmic reticulum
• cellular response to granulocyte macrophage colony-stimulating factor stimulus
• TPR domain binding
• establishment of endothelial barrier
• metal ion binding
• positive regulation of vascular permeability
• perinuclear region of cytoplasm
• negative regulation of transcription from RNA polymerase II promoter
• cyclic-nucleotide phosphodiesterase activity
• calcium ion transmembrane transport
• nucleus
• cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
• protein targeting to mitochondrion
• cellular response to transforming growth factor beta stimulus
• membrane raft
• cGMP binding
• cellular response to macrophage colony-stimulating factor stimulus
• cellular response to drug
• mitochondrial matrix
• presynaptic membrane
• positive regulation of inflammatory response
• monocyte differentiation
• cellular response to mechanical stimulus
• cGMP-mediated signaling
• negative regulation of vascular permeability

KEGG Pathways

• Morphine addiction
• Purine metabolism

GeneRIFs

• the phosphodiesterase 2A isoform localized to mitochondria regulates respiration [PMID 21724846]
• Active site similarity between human and Plasmodium falciparum phosphodiesterases: considerations for antimalarial drug design [PMID 21766240]
• TNF-alpha-mediated up-regulation of PDE2 may destabilize endothelial barrier function in sepsis [PMID 15650061]
• report the X-ray crystal structures of a PDE protein that includes both catalytic and regulatory domains, namely, PDE2A containing the N-terminal GAF domains and the catalytic domain. [PMID 19828435]
• found in smooth muscle wall of blood vessels transversing the clitoral supepithelial and stromal space [PMID 21697861]
• Phosphodiesterase 2 mediates redox-sensitive endothelial cell proliferation and angiogenesis by thrombin via Rac1 and NADPH oxidase 2. [PMID 19390057]
• Observational study of gene-disease association. (HuGE Navigator) [PMID 20351714]
• Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) [PMID 20628086]
• Affinity Capture-MS [PMID 21987572]
• Inhibition of PDE2 resulted in higher levels of intracellular cAMP than inhibition of PDE3A suggesting this PDE may be the more important regulator of cAMP in human platelets. [PMID 12038792]
• HIV-1 Tat decreases the intracellular levels of cAMP and CREB ser-133 phosphorylation through a signal transduction pathway involving sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases [PMID 11156964]
• roles of GAF domains in mouse phosphodiesterase 2A [PDE2a] [PMID 12271124]

PubMed Articles

Recent articles:

• Okada Y et al. “Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.” Nat Genet. 2012 Mar 25;44(5):511-6. PMID 22446963
• Lee KA et al. “Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.” J Biol Chem. 2011 Dec 2;286(48):41530-8. PMID 21987572
• Acin-Perez R et al. “A phosphodiesterase 2A isoform localized to mitochondria regulates respiration.” J Biol Chem. 2011 Sep 2;286(35):30423-32. PMID 21724846
• Howard BL et al. “Active site similarity between human and Plasmodium falciparum phosphodiesterases: considerations for antimalarial drug design.” J Comput Aided Mol Des. 2011 Aug;25(8):753-62. PMID 21766240
• Ückert S et al. “Expression and distribution of key enzymes of the cyclic GMP signaling in the human clitoris: relation to phosphodiesterase type 5 (PDE5).” Int J Impot Res. 2011 Sep-Oct;23(5):206-12. PMID 21697861
• Bosker FJ et al. “Poor replication of candidate genes for major depressive disorder using genome-wide association data.” Mol Psychiatry. 2011 May;16(5):516-32. PMID 20351714
• Bailey SD et al. “Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.” Diabetes Care. 2010 Oct;33(10):2250-3. PMID 20628086
• Macgregor S et al. “Genome-wide association identifies ATOH7 as a major gene determining human optic disc size.” Hum Mol Genet. 2010 Jul 1;19(13):2716-24. PMID 20395239
• Talmud PJ et al. “Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.” Am J Hum Genet. 2009 Nov;85(5):628-42. PMID 19913121
• Pandit J et al. “Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct.” Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18225-30. PMID 19828435

Top Pubmed articles linked to gene PDE2A matching any search term:

• Bailey SD et al. “Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.” Diabetes Care. 2010 Oct;33(10):2250-3. PMID 20628086
• Favot L et al. “VEGF-induced HUVEC migration and proliferation are decreased by PDE2 and PDE4 inhibitors.” Thromb Haemost. 2003 Aug;90(2):334-43. PMID 12888882