PLEKHF2

General Information

Full gene name:pleckstrin homology domain containing, family F (with FYVE domain) member 2 Entrez Gene ID:79666 Location:8q22.1 Synonyms:PHAFIN2, ZFYVE18 Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs896854	185438	upstream

NCBI Summary

None available.

OMIM

No OMIM data available for this gene.

NCBI Phenotypes

• Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines.
• NHGRI GWA Catalog

Gene Ontology

• protein binding
• phospholipid binding
• metal ion binding
• transport vesicle

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

• Two-hybrid [PMID 16189514]
• Two-hybrid [PMID 16189514]
• Two-hybrid [PMID 16189514]
• Two-hybrid [PMID 16189514]
• Two-hybrid [PMID 16189514]
• Two-hybrid [PMID 16189514]
• Two-hybrid [PMID 16189514]
• Two-hybrid [PMID 16189514]
• Two-hybrid [PMID 16189514]
• Two-hybrid [PMID 16189514]
• Two-hybrid [PMID 16189514]
• Two-hybrid [PMID 16189514]
• Two-hybrid [PMID 16189514]
• Two-hybrid [PMID 16189514]
• Two-hybrid [PMID 16189514]
• Two-hybrid [PMID 16189514]
• Two-hybrid [PMID 16189514]
• Two-hybrid [PMID 16189514]
• Two-hybrid [PMID 16189514]
• Two-hybrid [PMID 16189514]
• Two-hybrid [PMID 16189514]
• Results demonstrate that EAPF/Phafin-2 facilitates TNF-alpha-induced cellular apoptosis through an ER-mitochondrial apoptotic pathway. [PMID 18288467]
• These results provide a vivid example that an endosome modulator, such as Phafin2, may control the cells’ responses to the extracellular cues. [PMID 19995552]

PubMed Articles

Recent articles:

• Niu N et al. “Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines.” Genome Res. 2010 Nov;20(11):1482-92. PMID 20923822
• Lin WJ et al. “Phafin2 modulates the structure and function of endosomes by a Rab5-dependent mechanism.” Biochem Biophys Res Commun. 2010 Jan 1;391(1):1043-8. PMID 19995552
• Venkatesan K et al. “An empirical framework for binary interactome mapping.” Nat Methods. 2009 Jan;6(1):83-90. PMID 19060904
• Li C et al. “EAPF/Phafin-2, a novel endoplasmic reticulum-associated protein, facilitates TNF-alpha-triggered cellular apoptosis through endoplasmic reticulum-mitochondrial apoptotic pathway.” J Mol Med (Berl). 2008 Apr;86(4):471-84. PMID 18288467
• Olsen JV et al. “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.” Cell. 2006 Nov 3;127(3):635-48. PMID 17081983
• Mehrle A et al. “The LIFEdb database in 2006.” Nucleic Acids Res. 2006 Jan 1;34(Database issue):D415-8. PMID 16381901
• Rual JF et al. “Towards a proteome-scale map of the human protein-protein interaction network.” Nature. 2005 Oct 20;437(7062):1173-8. PMID 16189514
• Gerhard DS et al. “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” Genome Res. 2004 Oct;14(10B):2121-7. PMID 15489334
• Wiemann S et al. “From ORFeome to biology: a functional genomics pipeline.” Genome Res. 2004 Oct;14(10B):2136-44. PMID 15489336
• Ota T et al. “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Nat Genet. 2004 Jan;36(1):40-5. PMID 14702039

Top Pubmed articles linked to gene PLEKHF2 matching any search term:

• Lin WJ et al. “Phafin2 modulates the structure and function of endosomes by a Rab5-dependent mechanism.” Biochem Biophys Res Commun. 2010 Jan 1;391(1):1043-8. PMID 19995552