PLXNB3

General Information

Full gene name:plexin B3 Entrez Gene ID:5365 Location:Xq28 Synonyms:PLEXB3, PLXN6, PLEXR Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs3020789	136664	upstream

NCBI Summary

The protein encoded by this gene is a member of the plexin family. It functions as a receptor for semaphorin 5A, and plays a role in axon guidance, invasive growth and cell migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

OMIM

OMIM ID:`OMIM ID 300214 `_

NCBI Phenotypes

No phenotypes found linked to this gene.

Gene Ontology

• axon guidance
• protein binding
• signal transduction
• integral to membrane
• intracellular
• receptor activity
• plasma membrane

KEGG Pathways

• Axon guidance

GeneRIFs

• plexin B3 may influence cognitive performance, and the development of white matter in vivo in a way similar to its known stimulating effect on neurite outgrowth in vitro [PMID 17033634]
• Data suggest an involvement of homophilic interaction of B3 in semaphorin-independent signaling mechanisms positively influencing neuronal morphogenesis or function. [PMID 16122393]
• Data show that Semaphorin 5A (Sema5A) and plexin-B3 inhibit glioma cell invasion through Rac1 inactivation. [PMID 21706053]
• Data represent a novel signaling of semaphorin 5A and plexin B3 in the control of cell motility by indirect inactivation of Rac1 through RhoGDIalpha. [PMID 20696765]
• A virtual expression database search and RT-PCR analysis showed co-expression of SEMA5A and Plexin B3, and the interaction of SEMA5A with Plexin B3 was confirmed by co-immunoprecipitation studies. [PMID 19329067]
• Plexin-B3 is a functional receptor for semaphorin 5A [PMID 15218527]
• Two-hybrid [PMID 12421765]
• Two-hybrid [PMID 12421765]
• Two-hybrid [PMID 12421765]
• Affinity Capture-Western; Two-hybrid [PMID 12421765]
• Two-hybrid [PMID 12421765]
• Two-hybrid [PMID 12421765]

PubMed Articles

Recent articles:

• Li X et al. “Semaphorin 5A and plexin-B3 regulate human glioma cell motility and morphology through Rac1 and the actin cytoskeleton.” Oncogene. 2012 Feb 2;31(5):595-610. PMID 21706053
• Li X et al. “Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase.” J Biol Chem. 2010 Oct 15;285(42):32436-45. PMID 20696765
• Sadanandam A et al. “Identification of semaphorin 5A interacting protein by applying apriori knowledge and peptide complementarity related to protein evolution and structure.” Genomics Proteomics Bioinformatics. 2008 Dec;6(3-4):163-74. PMID 19329067
• Rujescu D et al. “Plexin B3 is genetically associated with verbal performance and white matter volume in human brain.” Mol Psychiatry. 2007 Feb;12(2):190-4, 115. PMID 17033634
• Hartwig C et al. “Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin.” BMC Neurosci. 2005 Aug 25;6:53. PMID 16122393
• Cheng J et al. “Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution.” Science. 2005 May 20;308(5725):1149-54. PMID 15790807
• Conrotto P et al. “Interplay between scatter factor receptors and B plexins controls invasive growth.” Oncogene. 2004 Jul 1;23(30):5131-7. PMID 15184888
• Artigiani S et al. “Plexin-B3 is a functional receptor for semaphorin 5A.” EMBO Rep. 2004 Jul;5(7):710-4. PMID 15218527
• Perrot V et al. “Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF.” J Biol Chem. 2002 Nov 8;277(45):43115-20. PMID 12183458
• Nakayama M et al. “Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.” Genome Res. 2002 Nov;12(11):1773-84. PMID 12421765