PNCK

General Information

Full gene name:pregnancy up-regulated non-ubiquitously expressed CaM kinase Entrez Gene ID:139728 Location:Xq28 Synonyms:BSTK3, CaMK1b Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs3020789	42201	downstream

NCBI Summary

PNCK is a member of the calcium/calmodulin-dependent protein kinase family of protein serine/threonine kinases (see CAMK1; MIM 604998) (Gardner et al., 2000 [PubMed 10673339]).[supplied by OMIM, Mar 2008]

OMIM

OMIM ID:`OMIM ID 300680 `_

NCBI Phenotypes

No phenotypes found linked to this gene.

Gene Ontology

• cytoplasm
• calmodulin binding
• nucleus
• ATP binding
• calmodulin-dependent protein kinase activity

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

• Pnck induces epidermal growth factor receptor degradation, most likely through perturbation of Hsp90 chaperone activity due to Hsp90 phosphorylation. Epidermal growth factor receptor degradation is coupled to proteasomal degradation of Pnck. [PMID 21325639]
• Pnck induces ligand-independent EGFR degradation, and it may represent an attractive therapeutic target in EGFR-regulated oncogenesis. [PMID 18562482]

PubMed Articles

Recent articles:

• Deb TB et al. “Pnck induces ligand-independent EGFR degradation by probable perturbation of the Hsp90 chaperone complex.” Am J Physiol Cell Physiol. 2011 May;300(5):C1139-54. PMID 21325639
• Deb TB et al. “Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation.” Am J Physiol Cell Physiol. 2008 Aug;295(2):C365-77. PMID 18562482
• Barbe L et al. “Toward a confocal subcellular atlas of the human proteome.” Mol Cell Proteomics. 2008 Mar;7(3):499-508. PMID 18029348
• Gerhard DS et al. “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” Genome Res. 2004 Oct;14(10B):2121-7. PMID 15489334
• Strausberg RL et al. “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.” Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. PMID 12477932
• Gardner HP et al. “The caM kinase, Pnck, is spatially and temporally regulated during murine mammary gland development and may identify an epithelial cell subtype involved in breast cancer.” Cancer Res. 2000 Oct 1;60(19):5571-7. PMID 11034105
• Gardner HP et al. “Cloning, characterization, and chromosomal localization of Pnck, a Ca(2+)/calmodulin-dependent protein kinase.” Genomics. 2000 Jan 15;63(2):279-88. PMID 10673339
• Bonaldo MF et al. “Normalization and subtraction: two approaches to facilitate gene discovery.” Genome Res. 1996 Sep;6(9):791-806. PMID 8889548

Top Pubmed articles linked to gene PNCK matching any search term:

• Witczak CA et al. “Ca2+/calmodulin-dependent protein kinase kinase-alpha regulates skeletal muscle glucose uptake independent of AMP-activated protein kinase and Akt activation.” Diabetes. 2007 May;56(5):1403-9. PMID 17287469
• Gardner HP et al. “Cloning, characterization, and chromosomal localization of Pnck, a Ca(2+)/calmodulin-dependent protein kinase.” Genomics. 2000 Jan 15;63(2):279-88. PMID 10673339
• Yang JM et al. “Increased expression of Galphaq protein in the heart of streptozotocin-induced diabetic rats.” Exp Mol Med. 1999 Dec 31;31(4):179-84. PMID 10630371