The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Recent articles:
- Kim W et al. “Systematic and quantitative assessment of the ubiquitin-modified proteome.” Mol Cell. 2011 Oct 21;44(2):325-40. PMID 21906983
- Oellerich T et al. “The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85.” EMBO J. 2011 Aug 5;30(17):3620-34. PMID 21822214
- Kim S et al. “Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders.” Mol Psychiatry. 2011 Apr;16(4):452-61. PMID 20308991
- Backx L et al. “PPP2R2C, a gene disrupted in autosomal dominant intellectual disability.” Eur J Med Genet. 2010 Sep-Oct;53(5):239-43. PMID 20601260
- Rose JE et al. “Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.” Mol Med. 2010 Jul-Aug;16(7-8):247-53. PMID 20379614
- Rung J et al. “Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.” Nat Genet. 2009 Oct;41(10):1110-5. PMID 19734900
- Glatter T et al. “An integrated workflow for charting the human interaction proteome: insights into the PP2A system.” Mol Syst Biol. 2009;5:237. PMID 19156129
- Goudreault M et al. “A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein.” Mol Cell Proteomics. 2009 Jan;8(1):157-71. PMID 18782753
- Eichhorn PJ et al. “A RNA interference screen identifies the protein phosphatase 2A subunit PR55gamma as a stress-sensitive inhibitor of c-SRC.” PLoS Genet. 2007 Dec;3(12):e218. PMID 18069897
- Ammosova T et al. “Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription.” Retrovirology. 2005 Jul 27;2:47. PMID 16048649
Top Pubmed articles linked to gene PPP2R2C matching any search term:
- Rung J et al. “Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.” Nat Genet. 2009 Oct;41(10):1110-5. PMID 19734900